2. Signaling Pathways
  3. GPCR/G Protein
  4. Trace Amine-associated Receptor (TAAR)
  5. Trace Amine-associated Receptor (TAAR) Antagonist

Trace Amine-associated Receptor (TAAR) Antagonist

Trace Amine-associated Receptor (TAAR) Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-147319
    RTI-7470-44
    		Antagonist 99.85%
    RTI-7470-44 is a potent, selective and blood-brain barrier (BBB) penetrant human trace amine-associated receptor subtype 1 (hTAAR1) antagonist with an IC50 value of 8.4 nM and a Ki value of 0.3 nM. RTI-7470-44 has moderate metabolic stability, and a favorable preliminary off-target profile. RTI-7470-44 can increase the spontaneous firing rate of mouse ventral tegmental area (VTA) dopaminergic neurons. RTI-7470-44 can be used for researching schizophrenia, agent addiction, and Parkinson’s disease (PD).