2. Signaling Pathways
  3. GPCR/G Protein
  4. Trace Amine-associated Receptor (TAAR)
  5. Trace Amine-associated Receptor (TAAR) Antagonist

Trace Amine-associated Receptor (TAAR) Antagonist

Trace Amine-associated Receptor (TAAR) Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-147319
    RTI-7470-44
    		Antagonist 99.85%
    RTI-7470-44 is an orally active and blood-brain barrier-permeable antagonist of trace amine-associated receptor 1 (hTAAR1) with a Ki of 0.3 nM. RTI-7470-44 inhibits hTAAR1-mediated cAMP production and signal transduction (IC50 = 8.4 nM), and blocks hTAAR1-mediated GIRK current responses. RTI-7470-44 increases the spontaneous firing frequency of dopaminergic neurons and reduces collagen-induced platelet aggregation. RTI-7470-44 can be used in studies related to Parkinson's disease and gastric emptying.