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Cat. No.: HY-P3926

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Amylin (8-37) (human)

(Synonyms: hIAPP (8-37))

Amylin (8-37) (human) (hIAPP (8-37)) is a 8-37 fragment of human islet amyloid polypeptide (IAPP). The duplex folding structure in the Amylin (8-37) (human) assembly has a hairpin structure.

For research use only. We do not sell to patients.

CAS No.: 309244-90-4
Formula: C₁₃₈H₂₁₅N₄₁O₄₆
Molecular Weight:3184.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Amylin (8-37) (human) Chemical Structure

CAS No.: 309244-90-4

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Amylin (8-37) (human) (hIAPP (8-37)) is a 8-37 fragment of human islet amyloid polypeptide (IAPP). The duplex folding structure in the Amylin (8-37) (human) assembly has a hairpin structure^[1].

In Vitro

Human islet amyloid polypeptide (hIAPP, amylin) is a major component in pancreatic amyloid deposits. Human IAPP with 37 amino acid residues is known to form soluble aggregates that further assemble into protofibrils and mature fibrils and eventually develop into plagues, and many studies have been conducted to identify the core regions with amyloidogenic properties. The assembly structures of Amylin (8-37) (human) (hIAPP (8-37)) shows lamella structures. The C terminal strands of Amylin (8-37) (human) peptides are stabilized by the coassembly molecule 4Bpy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 309244-90-4
Molecular Weight 3184.43
Formula C₁₃₈H₂₁₅N₄₁O₄₆
Synonyms

hIAPP (8-37)
Sequence Shortening

ATQRLANFLVHSSNNFGAILSSTNVGSNTY
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiao-Bo Mao, et al. Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19605-10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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