Anti-CD11a Antibody (AL-57)
Anti-CD11a Antibody (AL-57) is a monoclonal antibody targeting human CD11a. Anti-CD11a Antibody (AL-57) binds to HA cells in a dose-dependent manner but did not bind to LA cells. Anti-CD11a Antibody (AL-57) preferentially binds to the active conformation of LFA-1 and blocks LFA-1-mediated adhesion and lymphocyte proliferation. Anti-CD11a Antibody (AL-57) can be used for the research of inflammatory and autoimmune diseases.
For research use only. We do not sell to patients.
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Species Reactivity
Human
In Vitro
Anti-CD11a Antibody (AL-57) (0.01-100 nM; 30 min) specifically binds to HA K562 cells in a dose-dependent manner, with no binding to LA K562 cells[1].
Anti-CD11a Antibody (10 μg/mL; 30 min) preferentially binds to the activated high-affinity form of wild-type LFA-1 on PBMCs[1].
Anti-CD11a Antibody (0.01-100 nM; 30 min) potently blocks ICAM-1 binding to HA K562 cells with a mean IC50 of 0.4 ± 0.2 nM and to human PBMCs with a mean IC50 of 0.6 ± 0.4 nM[1].
Anti-CD11a Antibody (0.1-100 nM; 30 min) potently blocks HA K562 cell adhesion to primary human keratinocytes with a mean IC50 of 1.1 ± 0.8 nM[1].
Anti-CD11a Antibody (0.01-100 nM; 3 days) potently blocks PHA-induced proliferation of human PBMCs with a mean IC50 of 0.3 ± 0.1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:High-affinity (HA) K562 cells, Low-affinity (LA) K562 cells
-
Concentration:0.01-100 nM
-
Incubation Time:30 min
-
Result:Bound to HA cells in a dose-dependent manner, with mean fluorescence intensity (MFI) increasing with higher antibody concentrations.
Showed no binding to LA cells across all tested concentrations.
Gene ID
Accession
Target
CD11a
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
ELISA, FACS, Functional assay
Chemical Information
-
SMILES
[Anti-CD11a Antibody (AL-57)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-CD11a Antibody (AL-57) Related Classifications
HY-P992052 Related Classifications
Powered by Bioz
Keywords