Antibacterial agent 338
Antibacterial agent 338 (Compound 65) is an antibacterial agent and GyrB inhibitor, with an IC50 of 12.60 nM against GyrB from E. coli. Antibacterial agent 338 binds to the ATP-binding domain of E. coli GyrB, thereby inhibiting the ATPase activity of GyrB. Antibacterial agent 338 exhibits broad-spectrum antibacterial activity against multidrug-resistant Gram-negative bacteria. Antibacterial agent 338 reduces bacterial load in a neutropenic mouse thigh infection model. Antibacterial agent 338 can be used for the research of Acinetobacter baumannii infection.
For research use only. We do not sell to patients.
- Formula: C25H28FN9O
- Molecular Weight:489.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Antibacterial agent 338 (0.038-10000 nM; 60 min) potently inhibits the ATPase activity of E. coli DNA GyrB, with an IC50 value of 12.60 nM[1].
Antibacterial agent 338 (0.03-64 μg/mL; 18-20 h) exhibits broad-spectrum antibacterial activity against multidrug-resistant Gram-negative bacteria, with a MIC of 0.5 μg/mL against the multidrug-resistant *Acinetobacter baumannii* strain Aba-2024-D2-018[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR (half male and half female, 18-22 g, neutropenic via cyclophosphamide injection)[1]
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Dosage:10 mg/kg; 20 mg/kg; 20 mg/kg (two doses 6 hours apart)
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Administration:i.v.; single dose; two doses 6 hours apart
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Result:Achieved a bacterial burden reduction comparable to positive controls (levofloxacin and compound 9) at 20 mg/kg.
Produced a 2.65-log10 CFU/g reduction in bacterial burden.
Produced a 4.57-log10 CFU/g reduction, corresponding to >99.99% bacterial eradication, with bacterial burden reduced to pretreatment levels.
Chemical Information
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Molecular Weight 489.55
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Formula C25H28FN9O
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SMILES
C/C([C@H](N)C)=C(C1)/CN1C2=NC(OC3=CN=C(NC4CC4)N=C3)=NC5=C2C6=CC(F)=CC(NC)=C6N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 338 Related Classifications
HY-182936 Related Classifications
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- Antibacterial agent 338
- Antibacterial agent338
- Antibacterial agent-338
- Bacterial
- DNA/RNA Synthesis
- E. coli GyrB
- GyrB ATPase activity
- neutropenic murine thigh infection model
- hERG K+ channel
- CHO-hERG cells
- Acinetobacter baumannii
- DNA gyrase B
- multidrug-resistant acinetobacter baumannii infection
- multidrug-resistant Gram-negative bacteria
- ATP-binding domain
- Inhibitor
- inhibitor
- inhibit