AMPK beta 2 Antibody (YA5401)
(Synonyms: 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2; )
Based on 1 Customer Validation
AMPK beta 2 Antibody (YA5401) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK beta 2.
-
Host:
Mouse
-
Application:
IHC-P, WB
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
WB
WB: Western Blot
|
|---|---|---|
| Dilution Ratio | 1:50-200 | 1:1000-2000 |
Product Details
AMPK beta 2 Antibody (YA5401) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK beta 2.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 30 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Synthesized peptide derived from human AMPKβ2
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Shipping
Shipping with blue ice.
Background
-
Function
AMPK beta 2 is a Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)
-
Isoforms & Post-Translational Modification
O43741 has 2 isomers: O43741-1: 30302 Da (predicted); O43741-2: 21485 Da (predicted).
Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK -
Subunit
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3)
-
SwissProt ID
-
Synonyms
5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2;
Documentation
Powered by Bioz
