ARFGEF2 Antibody (YA2146)
(Synonyms: BIG2; PVNH2; dJ1164I10.1)ARFGEF2 Antibody (YA2146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ARFGEF2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
ARFGEF2 Antibody (YA2146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ARFGEF2.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 202 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 202 kDa
Entrez Gene: 10564 Human ; 99371 Mouse ; 296380 Rat
SwissProt: Q9Y6D5 Human ; A2A5R2 Mouse ; Q7TSU1 Rat
OMIM: 608097 Human
A synthetic peptide of human ARFGEF2 aa1501-1514.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ARFGEF2 promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways
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Subcellular Localization
Cytoplasm; Membrane; Golgi apparatus; Cytoplasm, perinuclear region; Golgi apparatus, trans-Golgi network; Endosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cell projection, dendrite; Cytoplasmic vesicle; Synapse; Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:Expressed in placenta, lung, heart, brain, kidney and pancreas -
Subunit
Homodimer (Probable). Interacts with ARFGEF1/BIG1; both proteins are probably part of the same or very similar macromolecular complexes.
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SwissProt ID
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Synonyms
BIG2; PVNH2; dJ1164I10.1
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Research Field
Signal Transduction
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