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CD28 Antibody (YA1092)

(Synonyms: CD28; T-cell-specific surface glycoprotein CD28; TP44; CD28)
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CD28 Antibody (YA1092) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD28.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • CD28 Antibody (YA1092) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-1:2000

Product Details

Description

CD28 Antibody (YA1092) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD28.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 16.5 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 16.5 kDa
Species Reactivity Database

Entrez Gene: 940 Human

SwissProt: P10747 Human

Immunogen

A synthesized peptide derived from human CD28

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD28, a cell surface glycoprotein receptor, predominantly expressed on activated T cells, belongs to the Ig superfamily and provides a critical co-stimulatory signal. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4. CD28 interacts with the CD80 dimer with relatively high affinity and the CD86 monomer with lower affinity, mediating T cell co-stimulation in conjunction with T cell receptor (TCR) signals. CD28 drives critical intracellular biochemical events including unique phosphorylation and transcriptional signaling, metabolism, and the production of key cytokines, chemokines, and survival signals that are essential for long-term expansion and differentiation of T cells. Most importantly, treatment of mice with a soluble CD28 antagonist induced antigen-specific tolerance that prevented the progression of autoimmune diseases and organ graft rejection.

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein; Cell surface

  • Expression


    Tissue_specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells

  • Isoforms & Post-Translational Modification

    CD28 has 7 isomers: P10747-1: 25066 Da (predicted); P10747-2: 11528 Da (predicted); P10747-3: 15369 Da (predicted); P10747-4: 14014 Da (predicted); P10747-5: 6099 Da (predicted); P10747-6: 8823 Da (predicted); P10747-7: 26186 Da (predicted).
    Phosphorylated by LCK. Dephosphorylated by PTPN11;Tyrosine phosphorylated induced by CD40LG

  • Subunit

    Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2. Interacts with PIK3R1. Interacts with PRKCQ

  • SwissProt ID

    P10747

  • Gene ID
    940 [NCBI]
  • Synonyms

    CD28; T-cell-specific surface glycoprotein CD28; TP44; CD28

  • Research Field

    Immunology

CD28 Antibody (YA1092) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CD28 Antibody (YA1092) Product Image