CEA Antibody (YA4783)(PBS only)

Cat. No.: HY-P85091A: Ficha de datos User Guide for Antibodies
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CEA Antibody (YA4783) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CEA.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

CEA Antibody (YA4783) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CEA.

Host

Mouse

Peso molecular

Predicted band size: 77 kDa;

Observed band size: 70-200 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P06731

Gene ID

1048 [NCBI]

Immunogen

KLH conjugated synthetic peptide derived from human CEA/CD66e/CEACAM5 : 41-140/702

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:500
IHC-F IHC-F: Immunohistochemistry-Frozen	1:400-:800
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:100-500

Pureza	affinity purified.	Conjugation	Non-conjugated

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050); (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer

Subcellular Localization：Cell membrane; Lipid-anchor, GPI-anchor; Apical cell membrane; Cell surface

Expression：
Tissue_specificity:Expressed (protein level) in colonic columnar epithelial cells and goblet cells (PubMed: 10436421) . Found in endoderm-derived digestive system epithelial adenocarcinoma and fetal colon.

Isoforms & Post-Translational Modification：P06731 has 2 isomers: P06731-1: 76796 Da (predicted); P06731-2: 76725 Da (predicted).
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate

Subunit：Homodimer

Synonyms

CEACAM5; CEA; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD antigen CD66e

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/scc-15-cell.html