CEP63 Antibody (YA8767)
(Synonyms: SCKL6)CEP63 Antibody (YA8767) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CEP63.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
CEP63 Antibody (YA8767) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CEP63.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 62.8 kDa
Full length human recombinant protein of human CEP63 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CEP63 is required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression. Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination[1][2][3][4][5].
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Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
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Isoforms & Post-Translational Modification
Q96MT8 has four isomers: Q96MT8-1: 81344 Da (predicted); Q96MT8-2: 63015 Da (predicted); Q96MT8-3: 57908 Da (predicted); Q96MT8-4: 55591 Da (predicted).
Polyubiquitinated via 'Lys-48'-linked ubiquitin, leading to its degradation (PubMed:35989368) -
Subunit
Interacts with CEP152 and CDK1; these interactions recruit both ligands to centrosomes (PubMed:21406398)
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SwissProt ID
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Synonyms
SCKL6
Documentation
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