CHMP5 Antibody (YA8092)
(Synonyms: C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2; Vps60)
Based on 1 Customer Validation
CHMP5 Antibody (YA8092) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHMP5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:2000 | 1:150-500 |
Product Details
CHMP5 Antibody (YA8092) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHMP5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 24.4 kDa
Full length human recombinant protein of human CHMP5 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CHMP5 is a Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release[1].
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Subcellular Localization
Cytoplasm, cytosol,Endosome membrane,Midbody
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Expression
Induction: Up-regulated by muramyl-dipeptide and lipopolysaccharide
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Isoforms & Post-Translational Modification
Q9NZZ3 has two isomers: Q9NZZ3-1: 24571 Da (predicted); Q9NZZ3-2: 19520 Da (predicted).
(Microbial infection) Stearoylated By S丨ISGylated -
Subunit
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III)
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SwissProt ID
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Synonyms
C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2; Vps60
Documentation
References
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