CRNN Antibody (YA8282)

Cat. No.: HY-P88598: Data Sheet User Guide for Antibodies
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CRNN Antibody (YA8282) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CRNN.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CRNN Antibody (YA8282) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CRNN.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 53.4 kDa

Species Reactivity

Human

SwissProt ID

Q9UBG3

Immunogen

Full length human recombinant protein of human CRNN produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-800

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832). Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832)

Subcellular Localization：Cytoplasm

Expression：
Tissue_Specificity: Expressed in the basal skin layer (at protein level) (PubMed:30009832). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR)
Induction: Up-regulated after heat shock, ponasterone A and deoxycholic acid (PubMed:15896671, PubMed:16640557). Induced in response to pro-inflammatory cytokines (PubMed:30009832)

Isoforms & Post-Translational Modification：Q9UBG3: 495 amino acids, molecular weight 53533 Da.

Subunit：Homodimer

Synonyms

C1orf10; DRC1; PDRC1; SEP53

Documentation

User Guide for Antibodies (1077 KB)