Cyclin C Antibody
(Synonyms: Cyclin-C, SRB11 homolog, hSRB11, CCNC)Cyclin C Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Cyclin C.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
Cyclin C Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Cyclin C.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 26-33 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22; 33 kDa
Purified recombinant protein of human Cyclin C
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cyclin C is a Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinases CDK8 and CDK19 that phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain. -
Isoforms & Post-Translational Modification
Cyclin C has 2 isoforms, P24863-1: amino acid length is 283, molecular weight is 33243 Da (predicted); P24863-2: amino acid length is 198, molecular weight is 22945 Da (predicted).
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Subunit
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11.
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SwissProt ID
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Synonyms
Cyclin-C, SRB11 homolog, hSRB11, CCNC
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