DCPS Antibody (YA8668)
(Synonyms: ARS; DCS1; HINT-5; HINT5; HSL1; HSPC015)DCPS Antibody (YA8668) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DCPS.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
DCPS Antibody (YA8668) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DCPS.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 38.4 kDa
Full length human recombinant protein of human DCPS produced in HEK293T cell
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DCPS is a Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death[1][2].
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Detected in liver, brain, kidney, testis and prostate
Induction: Up-regulated by menadione. Up-regulated by the transcription factor LTF isoform delta-lactoferrin (at protein level) -
Isoforms & Post-Translational Modification
Q96C86: 337 amino acids, molecular weight 38609 Da.
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Subunit
Homodimer
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SwissProt ID
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Synonyms
ARS; DCS1; HINT-5; HINT5; HSL1; HSPC015
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