DDX50 Antibody (YA8178)
(Synonyms: GU2; GUB; mcdrh; RH-II/GuB)DDX50 Antibody (YA8178) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DDX50.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:800-1500 |
Product Details
DDX50 Antibody (YA8178) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DDX50.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 82.4 kDa
Human recombinant protein fragment corresponding to amino acids 1-287 of human DDX50 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DDX50 is an ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta[1][2][3].
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Subcellular Localization
Nucleus, nucleolus,Cytoplasm
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Expression
Tissue_Specificity: Highest expression in skeletal muscle, liver, heart, placenta, and kidney -
Isoforms & Post-Translational Modification
Q9BQ39: 737 amino acids, molecular weight 82565 Da.
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Subunit
Interacts with C1QBP
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SwissProt ID
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Synonyms
GU2; GUB; mcdrh; RH-II/GuB
Documentation
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