Factor IX Antibody (YA1353)

製品番号: HY-P81608: データシート User Guide for Antibodies
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Factor IX Antibody (YA1353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Factor IX.

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容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

Factor IX Antibody (YA1353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Factor IX.

Host

Rabbit

Clonality

Recombinant,Monoclonal

分子量

Predicted band size: 52 kDa;

Observed band size: 52 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P00740

Gene ID

2158 [NCBI]

Immunogen

A synthesized peptide derived from human Factor IX aa50-110/461.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	純度	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa

Subcellular Localization：Secreted

Expression：
Tissue_specificity:Detected in blood plasma (at protein level) (PubMed:19846852, PubMed:2592373, PubMed:3857619, PubMed:8295821, PubMed:9169594) . Synthesized primarily in the liver and secreted in plasma

Isoforms & Post-Translational Modification：P00740 has 2 isomers: P00740-1: 51778 Da (predicted); P00740-2: 47618 Da (predicted).
Activated by factor XIa, which excises the activation peptide (PubMed:1730085, PubMed:9169594, PubMed:22961984). The propeptide can also be removed by snake venom protease (PubMed:20004170, PubMed:20080729). Activated by coagulation factor VIIa-tissue factor (F7-F3) complex in calcium-dependent manner (PubMed:271951);The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains

Subunit：Heterodimer of a light chain and a heavy chain; disulfide-linked (PubMed:20080729, PubMed:20121197, PubMed:20121198). Interacts (inactive and activated) with F11 (activated) in calcium-dependent manner (PubMed:22961984). Interacts with SERPINC1 (PubMed:20080729). Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (inactive and activated) with nitrophorin-2, an anticoagulant protein from Rhodnius prolixus (PubMed:10692472)

Database

Entrez Gene: 2158 Human

SwissProt: P00740 Human

OMIM: 306900 Human

Research Field

Cardiovascular

Synonyms

Coagulation factor IX; Christmas factor; Plasma thromboplastin component; PTC [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]

ドキュメンテーション

User Guide for Antibodies (1077 KB)