Factor IX Antibody (YA1353)
(Synonyms: Coagulation factor IX; Christmas factor; Plasma thromboplastin component; PTC [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain])Factor IX Antibody (YA1353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Factor IX.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Factor IX Antibody (YA1353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Factor IX.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 52 kDa
A synthesized peptide derived from human Factor IX aa50-110/461.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Factor IX is a Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:Detected in blood plasma (at protein level) (PubMed:19846852, PubMed:2592373, PubMed:3857619, PubMed:8295821, PubMed:9169594) . Synthesized primarily in the liver and secreted in plasma -
Isoforms & Post-Translational Modification
P00740 has 2 isomers: P00740-1: 51778 Da (predicted); P00740-2: 47618 Da (predicted).
Activated by factor XIa, which excises the activation peptide (PubMed:1730085, PubMed:9169594, PubMed:22961984). The propeptide can also be removed by snake venom protease (PubMed:20004170, PubMed:20080729). Activated by coagulation factor VIIa-tissue factor (F7-F3) complex in calcium-dependent manner (PubMed:271951);The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains -
Subunit
Heterodimer of a light chain and a heavy chain; disulfide-linked (PubMed:20080729, PubMed:20121197, PubMed:20121198). Interacts (inactive and activated) with F11 (activated) in calcium-dependent manner (PubMed:22961984). Interacts with SERPINC1 (PubMed:20080729). Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (inactive and activated) with nitrophorin-2, an anticoagulant protein from Rhodnius prolixus (PubMed:10692472)
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SwissProt ID
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Synonyms
Coagulation factor IX; Christmas factor; Plasma thromboplastin component; PTC [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
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Research Field
Cardiovascular
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