FOXC1 Antibody (YA1104)
(Synonyms: FOXC1; FKHL7, FREAC3; Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3 (FREAC-3))FOXC1 Antibody (YA1104) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXC1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
IHC-P
-
Reactivity :
Human
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
FOXC1 Antibody (YA1104) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXC1.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 57 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 57 kDa
Recombinant protein of human FOXC1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
FOXC1 is a transcription factors belonging to FOXC family. FOXC1 is an essential component in embryonic development of brain, eye and bone. FOXC1 knock-out mice die at birth with hydrocephalus, eye defects, and multiple skeletal abnormalities. FOXC1 is recently identified as a critical regulator for the niche formation of haematopoietic stem and progenitor cells, as well as hair follicle stem cells. Elevated expression of FOXC1 occur in a variety of cancers such as breast carcinoma, hepatocellular carcinomas, lymphoma and so on. FOXC1 promotes cancers through mediating cell proliferation, metastasis, epithelial–mesenchymal transition (EMT), angiogenesis and lymphangiogenesis[1].
-
Subcellular Localization
Nucleus
-
Expression
Tissue_specificity:Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090) . Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501) . Expressed in breast cancers (at protein level) (PubMed:26565916) . Expressed in hematopoietic cells (PubMed:8499623)
Induction:Up-regulated during the progression of epidermal keratinocyte differentiation (at protein level) (PubMed:27907090) . Up-regulated upon calcium-mediated keratinocyte differentiation (PubMed:27907090) . Up-regulated by transforming growth factor TGFB1 (PubMed:12408963) -
Subunit
Monomer. Interacts with C1QBP (PubMed:18676636). Interacts (via N-terminus) with GLI2 (via C-terminal internal region); this interaction is direct and increases GLI2 DNA-binding and transcriptional activity through a smoothened (SMO)-independent Hedgehog (Hh) signaling pathway (PubMed:26565916). Interacts (via C-terminus domain) with PITX2 isoform 3 (via homeobox domain) (PubMed:16449236). Interacts with FLNA and PBX1 (PubMed:15684392)
-
SwissProt ID
-
Synonyms
FOXC1; FKHL7, FREAC3; Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3 (FREAC-3)
-
Research Field
Epigenetics and Nuclear Signaling
Documentation
References
Powered by Bioz
