HSCB Antibody (YA8677)
(Synonyms: DNAJC20; HSC20; JAC1)HSCB Antibody (YA8677) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HSCB.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
HSCB Antibody (YA8677) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HSCB.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 27.2 kDa
Full length human recombinant protein of human HSCB produced in HEK293T cell
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HSCB acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Plays an essential role in hematopoiesis|Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT[1][2][3].
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Subcellular Localization
Cytoplasm,Mitochondrion
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Expression
Tissue_Specificity: Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart -
Isoforms & Post-Translational Modification
Q8IWL3: 235 amino acids, molecular weight 27422 Da.
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Subunit
Interacts with ISCU and HSPA9 to form an iron-sulfur transfer complex (PubMed:20668094)
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SwissProt ID
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Synonyms
DNAJC20; HSC20; JAC1
Documentation
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