Kv11.1 Antibody
(Synonyms: ERG, ERG1, HERG, KCNH2, Voltage-gated inwardly rectifying potassium channel KCNH2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1)Kv11.1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Kv11.1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
Kv11.1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Kv11.1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
Synthetic peptide of human Kv11.1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Kv11.1 is a Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity[1][2][3][4][5][6][7][8][9][10][11][12][13][14].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
Induction: Up-regulated by RNF207 (at protein level). -
Isoforms & Post-Translational Modification
Kv11.
Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. -
Subunit
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
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SwissProt ID
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Synonyms
ERG, ERG1, HERG, KCNH2, Voltage-gated inwardly rectifying potassium channel KCNH2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1
Documentation
References
[1]. Abbott GW, et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16;97(2):175-87. [Content Brief]
[2]. Kagan A, et al. The dominant negative LQT2 mutation A561V reduces wild-type HERG expression. J Biol Chem. 2000 Apr 14;275(15):11241-8. [Content Brief]
[3]. Paulussen A, et al. Analysis of the human KCNH2(HERG) gene: identification and characterization of a novel mutation Y667X associated with long QT syndrome and a non-pathological 9 bp insertion. Hum Mutat. 2000 May;15(5):483. [Content Brief]
[4]. Cui J, et al. Cyclic AMP regulates the HERG K(+) channel by dual pathways. Curr Biol. 2000 Jun 1;10(11):671-4. [Content Brief]
[5]. Yang P, et al. Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation. 2002 Apr 23;105(16):1943-8. [Content Brief]
[6]. Gong Q, et al. Role of glycosylation in cell surface expression and stability of HERG potassium channels. Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H77-84. [Content Brief]
[7]. Guasti L, et al. Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells. Mol Cell Biol. 2008 Aug;28(16):5043-60. [Content Brief]
[8]. Aidery P, et al. Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2. Biochem Biophys Res Commun. 2012 Feb 24;418(4):830-5. [Content Brief]
[9]. Ng CA, et al. The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating. PLoS One. 2012;7(2):e31640. [Content Brief]
[10]. Kang Y, et al. Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips). Biochem J. 2015 Nov 15;472(1):71-82. [Content Brief]
[11]. Li K, et al. Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins. Mol Cell. 2017 Jan 5;65(1):52-65. [Content Brief]
[12]. McDonald TV, et al. A minK-HERG complex regulates the cardiac potassium current I(Kr). Nature. 1997 Jul 17;388(6639):289-92. [Content Brief]
[13]. Lees-Miller JP, et al. Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts. Circ Res. 1997 Nov;81(5):719-26. [Content Brief]
[14]. Kupershmidt S, et al. A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current. J Biol Chem. 1998 Oct 16;273(42):27231-5. [Content Brief]
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