MAGE-3 Antibody (YA1109)
(Synonyms: HIP8; HYPD; CT1.3; MAGE3; MAGEA6)
Based on 1 Customer Validation
MAGE-3 Antibody (YA1109) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAGE-3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
MAGE-3 Antibody (YA1109) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAGE-3.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 35 kDa
Recombinant protein of human MAGEA3
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MAGE-3 is an Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes[1][2][3][4].
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Expression
Tissue_specificity:This gene is expressed in various types of tumors, such as melanoma, head and neck squamous cell carcinoma, lung cancer, and breast cancer, but not in normal tissues except for the testes and placenta. It has never been expressed in kidney tumors, leukemia, and lymphoma. -
Subunit
Interacts with TRIM28
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SwissProt ID
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Synonyms
HIP8; HYPD; CT1.3; MAGE3; MAGEA6
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Research Field
Tags & Cell Markers
Documentation
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