Olig2 Antibody (YA1012)
(Synonyms: Basic domain helix loop helix protein class B 1; Basic helix loop helix protein class B 1; BHLHB; bHLHB1; bHLHe19; Class B basic helix loop helix protein 1; Class B basic helix-loop-helix protein 1; class E basic helix loop helix protein 19)Olig2 Antibody (YA1012) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Olig2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Olig2 Antibody (YA1012) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Olig2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 32 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Entrez Gene: 10215 Human ; 50913 Mouse ; 304103 Rat
SwissProt: Q13516 Human ; Q9EQW6 Mouse ;
OMIM: 606386 Human
Purified recombinant human OLIG2 beta protein fragments expressed in E.coli.
Transfected
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
OLIG2 (oligodendrocyte transcription factor) is a basic helix-loop-helix transcription factor. The protein is of 329 amino acids in length, 32 kDa in size and contains one basic helix-loop-helix DNA-binding domain. It is one of the three members of the bHLH family. The other two members are OLIG1 and OLIG3. The expression of OLIG2 is mostly restricted in central nervous system, where it acts as both an anti-neurigenic and a neurigenic factor at different stages of development. OLIG2 is well known for determining motor neuron and oligodendrocyte differentiation, as well as its role in sustaining replication in early development. It is mainly involved in diseases such as brain tumor and Down syndrome.
OLIG2 is highly expressed in glioblastoma, astrocytoma and oligodendrogliomas, and it serves as a diagnostic marker for glial tumors. OLIG2 also plays a critical role in gliomagenesis and tumor phenotype plasticity. Furthermore, OLIG2 expression has been shown to correlate with survival in patients with SHH-MBs[1][2]. -
Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_specificity:This gene is expressed in oligodendrocytes in the brain. It is highly expressed in oligodendromas, but weakly to moderately expressed in astrocytomas. Its expression varies considerably in glioblastomas.
Induction:By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity) -
Subunit
Interacts with NKX2-2. Interacts with ZNF488
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SwissProt ID
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Synonyms
Basic domain helix loop helix protein class B 1; Basic helix loop helix protein class B 1; BHLHB; bHLHB1; bHLHe19; Class B basic helix loop helix protein 1; Class B basic helix-loop-helix protein 1; class E basic helix loop helix protein 19
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Research Field
Neuroscience
Documentation
[1]. Xu Z, et, al. OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma. Clin Cancer Res. 2022 Oct 3;28(19):4278-4291. [Content Brief]
[2]. Xu R, et, al. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. [Content Brief]
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