p73 Antibody (YA1240)
(Synonyms: TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein)p73 Antibody (YA1240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p73.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.17.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
p73 Antibody (YA1240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p73.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 70/60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 70 kDa
Recombinant protein of human p73
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.17.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
p73 participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression. It is an essential factor for the positive regulation of lung ciliated cell differentiation[1].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_specificity:Expressed in striatal neurons with Huntington disease (at protein level) . Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761)
Induction:Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction -
Isoforms & Post-Translational Modification
O15350 has 12 isomers: O15350-1: 69623 Da (predicted); O15350-2: 54322 Da (predicted); O15350-3: 53026 Da (predicted); O15350-4: 44517 Da (predicted); O15350-5: 61694 Da (predicted); O15350-6: 59887 Da (predicted); O15350-8: 64422 Da (predicted); O15350-9: 49121 Da (predicted); O15350-10: 47824 Da (predicted); O15350-11: 62034 Da (predicted); O15350-12: 38874 Da (predicted); O15350-13: 61694 Da (predicted).
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function;Higher levels of phosphorylation seen in the brain from patients with Huntington disease;Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome -
Subunit
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation. Interacts (via SAM domain) with NQO1; this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome
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SwissProt ID
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Synonyms
TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein
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Research Field
Cell Biology
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