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PEPD Antibody (YA1578)

(Synonyms: PROLIDASE)

PEPD Antibody (YA1578) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PEPD.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • PEPD Antibody (YA1578) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

PEPD Antibody (YA1578) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PEPD.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 55 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 55 kDa
Species Reactivity Database

Entrez Gene: 5184 Human

SwissProt: P12955 Human

Immunogen

Synthetic peptide of human PEPD (aa480-495).

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PEPD is a Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen[1][2][3].

  • Isoforms & Post-Translational Modification

    P12955 has 3 isomers: P12955-1: 54548 Da (predicted); P12955-2: 49691 Da (predicted); P12955-3: 47261 Da (predicted).

  • Subunit

    Homodimer

  • SwissProt ID

    P12955

  • Gene ID
    5184 [NCBI]
  • Synonyms

    PROLIDASE

  • Research Field

    Signal Transduction

[1]. Lupi A, et al. Human recombinant prolidase from eukaryotic and prokaryotic sources. Expression, purification, characterization and long-term stability studies. FEBS J. 2006 Dec;273(23):5466-78.

[2]. Rao SD, et al. M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome. Nat Chem Biol. 2022 May;18(5):565-574. [Content Brief]

[3]. Endo F, et al. Primary structure and gene localization of human prolidase. J Biol Chem. 1989 Mar 15;264(8):4476-81.

PEPD Antibody (YA1578) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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