Plectin Antibody (YA2915)

Cat. No.: HY-P83170: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Plectin Antibody (YA2915) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Plectin.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Plectin Antibody (YA2915) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Plectin Antibody (YA2915) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Plectin.

Host

Rabbit

Clonality

Recombinant, Monoclonal

Molecular Weight

Predicted band size: 532 kDa;

Observed band size: 532 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q15149

Gene ID

5339 [NCBI]

Immunogen

A synthesized peptide derived from human Plectin aa2-61.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
IP IP: Immunoprecipitation	1:30

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity

Subcellular Localization：Cytoplasm, cytoskeleton; Cell junction, hemidesmosome; Cell projection, podosome

Expression：
Tissue_specificity:Widely expressed with highest levels in muscle, heart, placenta and spinal cord

Isoforms & Post-Translational Modification：Q15149 has 9 isomers: Q15149-1: 531791 Da (predicted); Q15149-2: 518473 Da (predicted); Q15149-3: 518032 Da (predicted); Q15149-4: 516198 Da (predicted); Q15149-5: 516276 Da (predicted); Q15149-6: 516479 Da (predicted); Q15149-7: 512604 Da (predicted); Q15149-8: 513706 Da (predicted); Q15149-9: 514775 Da (predicted).
Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis

Subunit：Homodimer or homotetramer. Interacts (via actin-binding domain) with SYNE3. Interacts (via calponin-homology (CH) 1 domain) with VIM (via rod region) (By similarity). Interacts (via N-terminus) with DST isoform 2 (via N-terminus) (PubMed:19932097). Interacts with FER. Interacts with TOR1A (PubMed:18827015). Interacts with ANK3 (PubMed:21223964). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Interacts with COL17A1 (PubMed:12482924)

RRID

AB_3105285

Database

Entrez Gene: 5339 Human ; 18810 Mouse ;

SwissProt: Q15149 Human ; Q9QXS1 Mouse ; P30427 Rat

OMIM: 612138 Human

Research Field

Signal Transduction

Synonyms

EBS1; EBSO; HD1; Hemidesmosomal protein 1; PCN; pleC; PLEC1; Plectin 1; Plectin 6; Plectin; PLTN

Documentation

Select Batch:

Data Sheet (237 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Plectin Antibody (YA2915) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Plectin Antibody (YA2915)

Plectin Antibody (YA2915) Featured Recommendations:

Product Detail

Background

Documentation

Plectin Antibody (YA2915) Related Classifications

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