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Plectin Antibody (YA2915)

(Synonyms: EBS1; EBSO; HD1; Hemidesmosomal protein 1; PCN; pleC; PLEC1; Plectin 1; Plectin 6; Plectin; PLTN)
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Plectin Antibody (YA2915) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Plectin.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • Plectin Antibody (YA2915) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:50-1:100 1:30

Product Details

Description

Plectin Antibody (YA2915) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Plectin.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 532 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 532 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human Plectin aa2-61.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3105285

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Plectin is an Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity

  • Subcellular Localization

    Cytoplasm, cytoskeleton; Cell junction, hemidesmosome; Cell projection, podosome

  • Expression


    Tissue_specificity:Widely expressed with highest levels in muscle, heart, placenta and spinal cord

  • Isoforms & Post-Translational Modification

    Q15149 has 9 isomers: Q15149-1: 531791 Da (predicted); Q15149-2: 518473 Da (predicted); Q15149-3: 518032 Da (predicted); Q15149-4: 516198 Da (predicted); Q15149-5: 516276 Da (predicted); Q15149-6: 516479 Da (predicted); Q15149-7: 512604 Da (predicted); Q15149-8: 513706 Da (predicted); Q15149-9: 514775 Da (predicted).
    Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis

  • Subunit

    Homodimer or homotetramer. Interacts (via actin-binding domain) with SYNE3. Interacts (via calponin-homology (CH) 1 domain) with VIM (via rod region) (By similarity). Interacts (via N-terminus) with DST isoform 2 (via N-terminus) (PubMed:19932097). Interacts with FER. Interacts with TOR1A (PubMed:18827015). Interacts with ANK3 (PubMed:21223964). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Interacts with COL17A1 (PubMed:12482924)

  • SwissProt ID

    Q15149

  • Gene ID
    5339 [NCBI]
  • Synonyms

    EBS1; EBSO; HD1; Hemidesmosomal protein 1; PCN; pleC; PLEC1; Plectin 1; Plectin 6; Plectin; PLTN

  • Research Field

    Signal Transduction

Plectin Antibody (YA2915) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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