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PPM1D Antibody (YA7796)(PBS only)

(Synonyms: PP2C-DELTA; WIP1)

PPM1D Antibody (YA7796) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PPM1D.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • PPM1D Antibody (YA7796)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-2000

Product Details

Description

PPM1D Antibody (YA7796) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PPM1D.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 66.5 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-375 of human PPM1D produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PPM1D is involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity[1][2][3][4].

  • Subcellular Localization

    Nucleus,Cytoplasm, cytosol

  • Expression


    Tissue_Specificity: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts
    Induction: By p53/TP53

  • Isoforms & Post-Translational Modification

    O15297 has two isomers: O15297-1: 66675 Da (predicted); O15297-2: 47211 Da (predicted).

  • Subunit

    Interacts with CHEK1 and CHEK2; dephosphorylates them

  • SwissProt ID

    O15297

  • Synonyms

    PP2C-DELTA; WIP1

PPM1D Antibody (YA7796)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • PPM1D Antibody (YA7796)(PBS only) Product Image
    1/16
  • PPM1D Antibody (YA7796)(PBS only) Product Image