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RNF114 Antibody (YA6918)

(Synonyms: 1110008J21Rik antibody)

RNF114 Antibody (YA6918) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RNF114.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:1000

Product Details

Description

RNF114 Antibody (YA6918) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RNF114.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 26 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size：26 kDa
Immunogen

Recombinant protein within human RNF114 aa 1-228 / 228.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RNF114 is an E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. RNF114 acts as a negative regulator of NF-κB-dependent transcription by promoting the ubiquitination and stabilization of the NF-κB inhibitor TNFAIP3.

  • Subcellular Localization

    Cytoplasm,Nucleus

  • Expression


    Tissue_Specificity: Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis

  • Isoforms & Post-Translational Modification

    Q9Y508 has two isomers: Q9Y508-1: 25694 Da (predicted); Q9Y508-2: 21004 Da (predicted).
    Autoubiquitinated

  • Subunit

    Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling

  • SwissProt ID

    Q9Y508

  • Synonyms

    1110008J21Rik antibody

References

[1]. Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. [Content Brief]

RNF114 Antibody (YA6918) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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