SF3B3 Antibody (YA7645)
(Synonyms: KIAA0017, SAP130, SF3B3, Splicing factor 3B subunit 3, Pre-mRNA-splicing factor SF3b 130 kDa subunit, STAF130, Spliceosome-associated protein 130, SF3b130, SAP 130)
Based on 1 Customer Validation
SF3B3 Antibody (YA7645) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SF3B3.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
IHC-P, IHC-F, IF-Tissue
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in 10mM TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
IHC-F
IHC-F: Immunohistochemistry-Frozen
|
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
|
|---|---|---|---|
| Dilution Ratio | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
SF3B3 Antibody (YA7645) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SF3B3.
-
Host Rabbit
-
Clonality Recombinant
-
Species ReactivityHuman, Mouse, Rat Predicted Reactivity: Human,Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
-
Calculated Molecular Weight Predicted band size: 136 kDa;
KLH conjugated synthetic peptide derived from human SF3B3
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 10mM TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
SF3B3 component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs[1][2][3][4][5][6][7][8][9].
-
Subcellular Localization
Nucleus
-
Isoforms & Post-Translational Modification
Q15393 has three isomers: Q15393-1: 135577 Da (predicted); Q15393-2: 30210 Da (predicted); Q15393-3: 44606 Da (predicted).
-
Subunit
Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:11991638, PubMed:12234937, PubMed:15146077, PubMed:32494006, PubMed:34822310, PubMed:36797247)
-
SwissProt ID
-
Synonyms
KIAA0017, SAP130, SF3B3, Splicing factor 3B subunit 3, Pre-mRNA-splicing factor SF3b 130 kDa subunit, STAF130, Spliceosome-associated protein 130, SF3b130, SAP 130
Documentation
Powered by Bioz
