SLC22A17 Antibody (YA8306)
(Synonyms: 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3)
Based on 1 Customer Validation
SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500 | 1:500-800 |
Product Details
SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 55.5 kDa
Human recombinant protein fragment corresponding to amino acids 241-300 of human SLC22A17 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLC22A17 cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis
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Subcellular Localization
Cell membrane,Vacuole membrane
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Expression
Tissue_Specificity: Expressed in brain
Induction: Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway -
Isoforms & Post-Translational Modification
Q8WUG5 has three isomers: Q8WUG5-1: 68619 Da (predicted); Q8WUG5-2: 66590 Da (predicted); Q8WUG5-3: 32644 Da (predicted).
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SwissProt ID
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Synonyms
24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
Documentation
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