SLC22A17 Antibody (YA8306)

製品番号: HY-P88622: データシート SDS COA User Guide for Antibodies
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SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.

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容量	価格（税別）	在庫状況	数量
20 μL	$136	在庫あり	Estimated Time of Arrival: December 31
50 μL	$200	在庫あり	Estimated Time of Arrival: December 31
100 μL	$320	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 55.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8WUG5

Immunogen

Human recombinant protein fragment corresponding to amino acids 241-300 of human SLC22A17 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-800

Sensitivity	Endogenous	純度	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Solution

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity)

Subcellular Localization：Cell membrane,Vacuole membrane

Expression：
Tissue_Specificity: Expressed in brain
Induction: Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway

Isoforms & Post-Translational Modification：Q8WUG5 has three isomers: Q8WUG5-1: 68619 Da (predicted); Q8WUG5-2: 66590 Da (predicted); Q8WUG5-3: 32644 Da (predicted).

Synonyms

24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3

ドキュメンテーション

Select Batch:

データシート (231 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/hepg2-cell.html [Content Brief]