SPINK5 Antibody (YA2046)
(Synonyms: NS; NETS; LEKTI; LETKI; VAKTI)SPINK5 Antibody (YA2046) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPINK5.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
SPINK5 Antibody (YA2046) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPINK5.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 121 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 121 kDa
A synthetic peptide of human SPINK5
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SPINK5 serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate -
Isoforms & Post-Translational Modification
Q9NQ38 has 3 isomers: Q9NQ38-1: 120714 Da (predicted); Q9NQ38-2: 104017 Da (predicted); Q9NQ38-3: 124076 Da (predicted).
Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases -
SwissProt ID
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Synonyms
NS; NETS; LEKTI; LETKI; VAKTI
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Research Field
Cell Biology
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