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Thyroid Peroxidase Antibody (YA1480)

(Synonyms: MSA; TDH2A; TPO; TPX)
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Based on 1 Customer Validation

Thyroid Peroxidase Antibody (YA1480) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thyroid Peroxidase.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IP

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for Thyroid Peroxidase Antibody (YA1480)
  • Thyroid Peroxidase Antibody (YA1480) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:50-1:100 1:40

Product Details

Description

Thyroid Peroxidase Antibody (YA1480) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thyroid Peroxidase.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 103 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 103 kDa
Species Reactivity Database

Entrez Gene: 7173 Human

SwissProt: P07202 Human

Immunogen

A synthesized peptide derived from human TPO aa880-933.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3103841

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for Thyroid Peroxidase Antibody (YA1480)
    Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using Thyroid Peroxidase Antibody (HY-P81735, 1/100). The section was pretreated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked with quick block buffer for 0.5 hours at room temperature, washed with PBS and PBST, and then incubated with the primary antibody overnight at 4℃. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Background

  • Function

    Thyroid Peroxidase is an Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)

  • Subcellular Localization

    Membrane; Single-pass type I membrane protein; Cell surface

  • Isoforms & Post-Translational Modification

    P07202 has 8 isomers: P07202-1: 102963 Da (predicted); P07202-2: 96699 Da (predicted); P07202-3: 102771 Da (predicted); P07202-4: 98327 Da (predicted); P07202-5: 84581 Da (predicted); P07202-6: 67293 Da (predicted); P07202-7: 96507 Da (predicted); P07202-8: 92063 Da (predicted).
    Glycosylated;Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface;Cleaved in its N-terminal part

  • Subunit

    Interacts with DUOX1, DUOX2 and CYBA

  • SwissProt ID

    P07202

  • Gene ID
    7173 [NCBI]
  • Synonyms

    MSA; TDH2A; TPO; TPX

  • Research Field

    Signal Transduction

Thyroid Peroxidase Antibody (YA1480) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using Thyroid Peroxidase Antibody (HY-P81735, 1/100). The section was pretreated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked with quick block buffer for 0.5 hours at room temperature, washed with PBS and PBST, and then incubated with the primary antibody overnight at 4℃. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

  • Thyroid Peroxidase Antibody (YA1480) Product Image
    1/16
  • Experimental Validation Results for Thyroid Peroxidase Antibody (YA1480)
  • Thyroid Peroxidase Antibody (YA1480) Product Image
  • Experimental Validation Results for Thyroid Peroxidase Antibody (YA1480)
    1/1
    MedChemExpress Validation
     Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using Thyroid Peroxidase Antibody (HY-P81735, 1/100). The section was pretreated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked with quick block buffer for 0.5 hours at room temperature, washed with PBS and PBST, and then incubated with the primary antibody overnight at 4℃. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
  • Experimental Validation Results for Thyroid Peroxidase Antibody (YA1480)
  • Thyroid Peroxidase Antibody (YA1480) Product Image
    MedChemExpress Validation

    Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using Thyroid Peroxidase Antibody (HY-P81735, 1/100). The section was pretreated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked with quick block buffer for 0.5 hours at room temperature, washed with PBS and PBST, and then incubated with the primary antibody overnight at 4℃. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

  • Thyroid Peroxidase Antibody (YA1480) Product Image IHC-P