Trk C Antibody (YA5089)

Cat. No.: HY-P85397: Data Sheet User Guide for Antibodies
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Trk C Antibody (YA5089) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Trk C.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Trk C Antibody (YA5089) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Trk C.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 91 kDa;

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q16288

Gene ID

4916 [NCBI]

Immunogen

Recombinant human Ntrk3. The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1000

Sensitivity	Endogenous	Purity	affinity purified by Protein G
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1, k

Appearance

Liquid

Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation

Subcellular Localization：Membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:It is widely expressed, but mainly found in neural tissue. Isomer 2 is expressed at a higher level in the human brain than in the fetal brain.

Isoforms & Post-Translational Modification：Q16288 has 5 isomers: Q16288-1: 94428 Da (predicted); Q16288-2: 68452 Da (predicted); Q16288-3: 92801 Da (predicted); Q16288-4: 93460 Da (predicted); Q16288-5: 91833 Da (predicted).
Ligand-mediated auto-phosphorylation

Subunit：Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546). Interacts with MAPK8IP3/JIP3 (By similarity)

Synonyms

NTRK3; TRKC; NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase

Documentation

User Guide for Antibodies (1077 KB)