TRP1 Antibody (YA1247)
(Synonyms: CAS2; CATB; GP75; OCA3; TRP1; TYRP; TYRP1; TYRRP; DHICA oxidase)TRP1 Antibody (YA1247) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.92.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
TRP1 Antibody (YA1247) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRP1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 61 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 61 kDa
Recombinant protein of human TRP1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.92.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TRP1 plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin[1][2][3][4].
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Subcellular Localization
Melanosome membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:pigment cells -
Subunit
Monomer (PubMed:28661582). Interacts with ATP7A (By similarity) (PubMed:28661582). Interacts with SLC45A2 (By similarity)
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SwissProt ID
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Synonyms
CAS2; CATB; GP75; OCA3; TRP1; TYRP; TYRP1; TYRRP; DHICA oxidase
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Research Field
Tags & Cell Markers
Documentation
[1]. Rooryck C, et al. Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient. Pigment Cell Res. 2006 Jun;19(3):239-42. [Content Brief]
[2]. Kenny EE, et al. Melanesian blond hair is caused by an amino acid change in TYRP1. Science. 2012 May 4;336(6081):554. [Content Brief]
[3]. Simeonov DR, et al. DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics. Hum Mutat. 2013 Jun;34(6):827-35. [Content Brief]
[4]. Lai X, et al. Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9812-9815. [Content Brief]
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