ZRANB1 Antibody (YA8045)
(Synonyms: TRABID)ZRANB1 Antibody (YA8045) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZRANB1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:2000-2500 |
Product Details
ZRANB1 Antibody (YA8045) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZRANB1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 80.8 kDa
Human recombinant protein fragment corresponding to amino acids 208-296 of human ZRANB1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ZRANB1 is an Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration[1][2][3][4][5][6][7].
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Widely expressed -
Isoforms & Post-Translational Modification
Q9UGI0: 708 amino acids, molecular weight 80967 Da.
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Subunit
Interacts with TRAF6 (PubMed:11463333)
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SwissProt ID
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Synonyms
TRABID
Documentation
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