CBP/p300-IN-15
CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC50 values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC50 values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research.
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- CAS. Nr.: 2379409-91-1
- Formel: C26H28N4O5
- Molecular Weight:476.52
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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CBP 28 nM (IC50) |
p300 2.5 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | EC50 |
2.71 μM
Compound: 13a
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Antiproliferative activity against human A2780 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
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[PMID: 34801827] |
| MV4-11 | IC50 |
64.3 nM
Compound: 626; B003
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Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay
Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay
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[PMID: 31910017] |
| OVCAR-3 | EC50 |
0.865 μM
Compound: 13a
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Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
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[PMID: 34801827] |
Chemical Information
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CAS. Nr. 2379409-91-1
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Molecular Weight 476.52
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Formel C26H28N4O5
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SMILES
CNC(NC1=CC=C2C(CC[C@@]23OC(N(C3=O)CC(N4CC5=CC=CC=C5CC[C@H]4C)=O)=O)=C1)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CBP/p300-IN-15 Related Classifications
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