β-Terpinene
β-Terpinene is a naturally occurring monoterpene, prohapten/metabolic substrate, and contact allergen inducer, with moderate potency as a sensitizer.β-Terpinene undergoes metabolic activation to epoxides that conjugate with glutathione.β-Terpinene induces contact allergy via reactive allylic epoxide metabolites.β-Terpinene does not significantly reduce growth of Erwinia amylovora at concentrations up to 1500 mg/l.β-Terpinene can be used for the research of Aspergillus flavus infection.
For research use only. We do not sell to patients.
- CAS No.: 99-84-3
- Formula: C10H16
- Molecular Weight:136.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
β-Terpinene (compound 5) can be metabolically activated by human and female CD-1 mouse liver microsomes to form reactive electrophilic metabolites capable of conjugating with glutathione, and distinct conjugate profiles are generated in the two microsomal systems[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 (female)[2]
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Dosage:1% w/v; 10% w/v; 25% w/v
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Administration:topical; single application
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Result:Recorded mean [3H]thymidine incorporation of 873 dpm/lymph node with a stimulation index (SI) of 1.4 at 1% w/v.
Recorded mean [3H]thymidine incorporation of 839 dpm/lymph node with an SI of 1.3 at 10% w/v.
Recorded mean [3H]thymidine incorporation of 1337 dpm/lymph node with an SI of 2.1 at 25% w/v.
Determined the estimated EC3 value (concentration required to induce an SI of 3) was >25% w/v (>1.8 M).
Chemical Information
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CAS No. 99-84-3
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Molecular Weight 136.24
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Formula C10H16
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SMILES
C=C1CC=C(CC1)C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Terpinene Related Classifications
HY-184853 Related Classifications
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