Rippling muscle disease

Rippling muscle disease (RMD) is an autosomal-dominant disorder of skeletal muscle characterized by signs of increased muscle irritability, such as percussion-induced rapid contraction (PIRC), percussion-induced muscle mounding (PIMM), and/or electrically silent muscle contractions (rippling muscle). Many cases of RMD are caused by mutations in caveolin-3, and aberrations in the tubular system are commonly observed.