1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. BR102375

BR102375 

Cat. No.: HY-128344
Handling Instructions

BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28 μM and Amax ratio of 98%.

For research use only. We do not sell to patients.

BR102375 Chemical Structure

BR102375 Chemical Structure

CAS No. : 2366255-59-4

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Description

BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28 μM and Amax ratio of 98%[1].

In Vitro

BR102375 (Compound 18) (10 μM) increases gene expression levels relevant to PPARγ activation and enhances glucose uptake under insulin stimulation[1].
BR102375 (Compound 18) (10 nM, 100 nM, 1 μM; 6 days, 14 days) shows a concentration-dependent, insulin-sensitive effects on adipogenesis[1].

RT-PCR[1]

Cell Line: 3T3-L1 mouse preadipocyte cells
Concentration: 10 μM
Incubation Time:
Result: Increased AP2 and CD36 cells gene mRNA expression and enhanced glucose uptake when stimulated by insulin.
In Vivo

BR102375 (Compound 18) has decent efficacy on mouse diabetes model[1].
BR102375 reveals significant suppressive effect on random blood glucose increase(75 mpk, p.o., bid), shows decent effect on insulin resistance on Oral glucose tolerance test (OGTT) and discloses similar findings in body weight gain almost identical to Pioglitazone[1].

Molecular Weight

554.64

Formula

C₃₁H₃₄N₆O₄

CAS No.

2366255-59-4

SMILES

CCCCC(N1CC2=CC=C(C3=C(C4=NOC(N4)=O)C=CC=C3)C=C2)=NC(C)=C(CC5=NC(C(C)(C)C)=NO5)C1=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BR102375
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