製品番号: HY-B0480A

Brompheniramine

(別名: (±)-Brompheniramine)

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.

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純度: 99.82%
CAS 番号: 86-22-6
分子式: C₁₆H₁₉BrN₂
分子量:319.24

保管条件:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Brompheniramine 構造式

CAS 番号: 86-22-6

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価格（税別）

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数量

Amount: USD 0.00

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (2)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

H₁ Receptor

Histamine Receptor アイソフォーム固有の製品をすべて表示 :

mAChR アイソフォーム固有の製品をすべて表示 :

Sodium Channel アイソフォーム固有の製品をすべて表示 :

Calcium Channel アイソフォーム固有の製品をすべて表示 :

体外実験

Brompheniramine (0.1-100 μM) blocks hERG K⁺ channels expressed in CHO cells in a concentration-dependent manner with an IC₅₀ of 0.90±0.14 μM, and reduced peak tail current amplitude measured at -60 mV (cells are depolarized for 2 s to +20 mV from a holding potential of -80 mV followed by a 3s repolarization back to -60 mV)^[3].
Brompheniramine (1, 10 and 100 μM) significantly shortens the APD₅₀ and depresses the plateau phase on the action potential in guinea pig papillary muscle, as well as slightly prolongs the APD₉₀ in guinea pig papillary muscle at 10 and 100 μM^[3].
Brompheniramine (0.1-100 μM) inhibit the amplitude of the Ca²⁺ channel currents in rat ventricular myocytes by 14.1±1.1, 31.1±5.8, 38.0±3.8 and 90.2±3.7% at 0.1, 1, 10 and 100 μM, respectively^[3].
Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Brompheniramine (0.3-3 μM; SC, single dosage) induces cutaneous analgesia in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats^[1]
Dosage:

0.3, 0.6, 1.1, 1.5 and 3.0  μM
Administration:

SC, single dosage
Result:

Provoked cutaneous analgesia in a dose-dependent manner, with an EC₅₀ value of 0.66 μM, and induced prolonged analgesic duration.

化学情報

CAS 番号 86-22-6
性状 Liquid
分子量 319.24
分子式 C₁₆H₁₉BrN₂
Color Colorless to light yellow
SMILES

CN(C)CCC(C1=CC=C(Br)C=C1)C2=CC=CC=N2
別名

(±)-Brompheniramine
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Biomaterials

Cellhesion VP enhances the immunomodulating potential of human mesenchymal stem cell-derived extracellular vesicles. [Abstract]

2021 Apr:271:120742. PMID: 33706111
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (313.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1324 mL

15.6622 mL

31.3244 mL

5 mM

0.6265 mL

3.1324 mL

6.2649 mL

10 mM

0.3132 mL

1.5662 mL

3.1324 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chong-Chi Chiu, et al. Subcutaneous brompheniramine for cutaneous analgesia in rats. Eur J Pharmacol. 2019 Oct 5;860:172544. [Content Brief]

[2]. B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [Content Brief]

[3]. Shin WH, Kim KS, Kim EJ. Electrophysiological effects of brompheniramine on cardiac ion channels and action potential. Pharmacol Res. 2006 Dec;54(6):414-20. [Content Brief]

[4]. Yasuda SU, Yasuda RP. Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1324 mL	15.6622 mL	31.3244 mL	78.3110 mL
	5 mM	0.6265 mL	3.1324 mL	6.2649 mL	15.6622 mL
	10 mM	0.3132 mL	1.5662 mL	3.1324 mL	7.8311 mL
	15 mM	0.2088 mL	1.0441 mL	2.0883 mL	5.2207 mL
	20 mM	0.1566 mL	0.7831 mL	1.5662 mL	3.9155 mL
	25 mM	0.1253 mL	0.6265 mL	1.2530 mL	3.1324 mL
	30 mM	0.1044 mL	0.5221 mL	1.0441 mL	2.6104 mL
	40 mM	0.0783 mL	0.3916 mL	0.7831 mL	1.9578 mL
	50 mM	0.0626 mL	0.3132 mL	0.6265 mL	1.5662 mL
	60 mM	0.0522 mL	0.2610 mL	0.5221 mL	1.3052 mL
	80 mM	0.0392 mL	0.1958 mL	0.3916 mL	0.9789 mL
	100 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7831 mL

Keywords

Brompheniramine

2 Cited Publications

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Brompheniramine

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MedChemExpress（MCE）の使用を引用している文献 Brompheniramine

Histamine Receptor アイソフォーム固有の製品をすべて表示

mAChR アイソフォーム固有の製品をすべて表示

Sodium Channel アイソフォーム固有の製品をすべて表示

Calcium Channel アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Brompheniramine 関連分類

HY-B0480A 関連分類