SMYD3-IN-2
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Formula: C26H21BrN2O4
- Molecular Weight:505.36
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
|
SMYD3 0.81 μM μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BGC-823 | IC50 |
0.75 μM
Compound: 7r
|
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
|
[PMID: 36527933] |
SMYD3-IN-2 (compound 7r) (1.0 μM) exhibits potent inhibitory capacity against SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively[1].
SMYD3-IN-2 (1.0 μM; 24 h) can suppress Akt methylation and activation by SMYD3[1].
SMYD3-IN-2 (0-48 h) suppresses the proliferation of BGC823 stomach adenocarcinoma cells by inducing autophagic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BGC823 cells
-
Concentration:1.0 μM
-
Incubation Time:24 h
-
Result:Suppressed the methylation levels of H3K4 and could significantly inhibit the lysine methylation of Akt1 by SMYD3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Xenograft Balb/c nude mice models[1]
-
Dosage:15 and 30 mg/kg
-
Administration:Intraperitoneally administration
-
Result:Remarkably suppressed the tumor volume, tumor weight and growth curves of gastric cancer xenografts in a dose-dependent manner.
Resulted in strong immunohistochemistry staining of LC3-II and p62, weak staining of p-Akt (T308) and Ki67.
Chemical Information
-
Molecular Weight 505.36
-
Formula C26H21BrN2O4
-
SMILES
[H][C@]12CN(C([C@]1(O[C@@]3([C@@H]2C4=CC=C(C=C4)Br)C(NC5=CC=CC=C53)=O)O)=O)CC6=CC=CC=C6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMYD3-IN-2 Related Classifications
HY-152228 Related Classifications
Powered by Bioz