Cat. No.: HY-16658B

Z-VAD-FMK

(Synonyms: Z-VAD(OH)-FMK)

755 Cited Publications

Customer Review

Based on 755 publication(s) in Google Scholar

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis.

For research use only. We do not sell to patients.

Purity: 98.03%
CAS No.: 161401-82-7
Formula: C₂₁H₂₈FN₃O₇
Molecular Weight:453.46

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Z-VAD-FMK Chemical Structure

CAS No.: 161401-82-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (755)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Caspase

All Caspase Isoforms :

All RIP kinase Isoforms :

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

In Vitro

Z-VAD-FMK (100 μM, 8 h) can induce both autophagy and necrosis in J774A.1 macrophages, indicating that it can trigger non-apoptotic cell death pathways^[2].
Z-VAD-FMK (20 μM, 48 h) significantly improves the cryotolerance of Bovine in vitro produced blastocysts by inhibiting apoptosis, and improves the survival and development of embryos after thawing^[3].
Z-VAD-FMK (20 μM, 48 h) directly inhibits caspase-3 activation, demonstrating that it improves the cryotolerance of bovine blastocysts by blocking the apoptosis pathway^[3].
Z-VAD-FMK (0-100 μM, 72 h) dose-dependently inhibits T cell proliferation mediated through the co-stimulation with anti-CD3 and anti-CD28^[4].
Z-VAD-FMK (50-100 μM, 16 h) significantly inhibits FasL-induced T cell apoptosis and caspase-8/caspase-3 treatment^[4].
Z-VAD-FMK (25-100 μM, 6-24 h) can deplete and activate GSH in anti-CD3 antibody-pretreated peripheral blood mononuclear cells (PBMCs) following prolonged incubation^[5].
Z-VAD-FMK (25-100 μM, 6-24 h) significantly increases ROS levels in primary T cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:

FasL-induced T cells
Concentration:

50 μM, 100 μM
Incubation Time:

16 h
Result:

Effectively inhibited caspase activity in the apoptosis model, but had no effect on T cell activation.

In Vivo

Z-VAD-FMK (3 mg/kg, i.p., once every other day, for 3 months) can reduce inflammation and mucus secretion in mice induced by cigarette smoke^[6].
Z-VAD-FMK (50 μmol/L (0.3 mL), i.p., 30 mins before modeling) significantly reduces severe acute pancreatitis (SAP)-induced lung tissue pathological damage in a SAP model in rats^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Thirty-two 6-7-week-old male C57BL/6J mice were exposed to cigarette smoke (CS)^[6].
Dosage:

3 mg/kg
Administration:

I.P., once every other day, for 3 months
Result:

Significantly reduced airway inflammation and emphysema lesions caused by CS exposure.
Lowered serum IL-1β, IL-8, and IL-1β levels in BALF.
Had no significant inhibitory effect on mucus secretion (Muc5ac).

Animal Model:

Seventy-two male Sprague-Dawley rats (weighing 250-300 g) were anesthetized by intraperitoneal injection of ketamine (100 mg/kg), followed by laparotomy and retrograde injection of 5% sodium taurocholate (1.0 mL/kg) into the pancreatic duct via the duodenal papilla^[7].
Dosage:

50 μmol/L (0.3 mL)
Administration:

I.p., 30 mins before modeling
Result:

Significantly alleviated SAP-induced pathological damage to lung tissue (edema, inflammatory infiltration, and hemorrhage).
Inhibiting cleaved caspase-3 expression blocked lung cell apoptosis.
Reduced myeloperoxidase (MPO) activity and inflammatory cytokine (IL-1β, TNF-α) levels, inhibiting neutrophil infiltration and inflammatory responses.

Chemical Information

CAS No. 161401-82-7
Appearance Solid
Molecular Weight 453.46
Formula C₂₁H₂₈FN₃O₇
Color White to light yellow
SMILES

O=C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CF)=O)=O)=O)C(C)C)OCC1=CC=CC=C1
Synonyms

Z-VAD(OH)-FMK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (755)

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Journal Impact Factor

Signal Transduct Target Ther

Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity. [Abstract]

2024 Feb 28;9(1):43. PMID: 38413575
Science

A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. [Abstract]

2021 Mar 5;371(6533):eabb2224. PMID: 33446483
Cell

Red blood cells undergo lytic programmed cell death involving NLRP3. [Abstract]

2025 May 29;188(11):3013-3029.e19. PMID: 40252640
Cell

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. [Abstract]

2024 Dec 26;187(26):7533-7550.e23. PMID: 39500322
Cell

Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death. [Abstract]

2024 Feb 1;187(3):624-641.e23. PMID: 38211590
Nat Biotechnol

NIS-Seq enables cell-type-agnostic optical perturbation screening. [Abstract]

2024 Dec 19. PMID: 39702735
Cancer Discov

NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. [Abstract]

2024 Sep 13:OF1-OF20. PMID: 39269178
Cell Res

Signal-induced NLRP3 phase separation initiates inflammasome activation. [Abstract]

2025 Apr 1. PMID: 40164768
Drug Resist Updat

DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. [Abstract]

2025 Jul:81:101224. PMID: 40058099
Bioact Mater

Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. [Abstract]

2021 Nov 19;13:23-36. PMID: 35224289

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]

H1299 and H460 cells are treated with curcumenol with or without Z-VAD-FMK (10 μM) for 24 h, the cell viability is detected.
Cell Mol Immunol

cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes. [Abstract]

2023 Oct;20(10):1203-1215. PMID: 37591930
Nat Microbiol

Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children. [Abstract]

2026 Jul;11(7):1967-1981. PMID: 42304079
Nat Microbiol

Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages. [Abstract]

2025 Nov;10(11):2949-2965. PMID: 41073667
Nat Microbiol

Dual inhibition of innate immunity and apoptosis by human cytomegalovirus protein UL37x1 enables efficient virus replication. [Abstract]

2022 Jul;7(7):1041-1053. PMID: 35637330

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2022 Jul;7(7):1041-1053. [Abstract]

HFFs stably expressing UL37x1 or empty vector are infected with HCMV in the presence of z-VAD-FMK. At 0, 6 and 12 h.
Nat Cell Biol

De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence. [Abstract]

2023 Jun;25(6):836-847. PMID: 37291265

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Jun;25(6):836-847. [Abstract]

Cell viability of HeLa cells treated with brequinar (0.3 μM) or/and AICAR (40 μM)/A-769662 (200 μM)/MK-8722 (1 μM) for 72 h following pretreatment with vehicle or cell death inhibitors for 24 h. Ferr-1 (10 μM), Z-VAD-FMK (10 μM), necrosulfonamide (2 μM).
Adv Funct Mater

2023 May 14.

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2023 May 14.

The viability of MC38 cells treated with PAD@MS for 48 h in the presence or absence of 10 µM Ferr-1 (Ferrostatin-1), 20 µM Nec-1 (Necrostatin-1), 10 µM Z-VAD-FMK, and 1 mM NAC.

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2023 May 14.

The viability of MC38 cells treated with (A) MTO, (B) SAS, (C) M+S, and (D) PD@MS for 48 h in the presence or absence of 10 µM Ferr-1, 20 µM Nec-1, 10 µM Z-VADFMK, and 1 mM NAC.
Cell Host Microbe

Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival. [Abstract]

2023 Nov 8;31(11):1820-1836.e10. PMID: 37848028
Cancer Res

Lactate-Activated GPR132 Signaling Drives a Tumor Microenvironmental Autocrine Metabolic Loop in Kidney Cancer. [Abstract]

2026 Jun 6. PMID: 42258526
Cancer Res

Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma that Drives Antitumor Immunity. [Abstract]

2025 Aug 19. PMID: 40828991
Cancer Res

CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer. [Abstract]

2025 Aug 29. PMID: 40882016
Cancer Res

Androgen receptor variants confer castration resistance in prostate cancer by counteracting antiandrogen-induced ferroptosis. [Abstract]

2023 Oct 2;83(19):3192-3204. PMID: 37527336
Sci Immunol

Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [Abstract]

2026 Apr 3;11(118):eaeb6484. PMID: 41931597
Sci Immunol

Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium. [Abstract]

2024 Jul 12;9(97):eadn0178. PMID: 38996010
ACS Nano

Mitochondria-Targeted Microneedles Reverse Doxorubicin Resistance via Apoptosis-Ferroptosis Synergy. [Abstract]

2025 Jul 1;19(25):23315-23333. PMID: 40534228
Nat Commun

Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation. [Abstract]

2026 Jan 31;17(1):2227. PMID: 41620436
Nat Commun

Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis. [Abstract]

2025 Dec 8. PMID: 41361241
Nat Commun

Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma. [Abstract]

2025 Nov 18;16(1):10096. PMID: 41253833
Nat Commun

RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis. [Abstract]

2025 Aug 7;16(1):7309. PMID: 40774959

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 7;16(1):7309. [Abstract]

hBMECs were pretreated with Necrosulfonamide (NSA) (20 μM) or zVAD alone or in combination for 0.5 h, followed by infection with RS218 at an MOI of 1 or 10. LDH release (n=6 biologically independent samples) was assayed.
Nat Commun

DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species. [Abstract]

2025 Jul 30;16(1):6996. PMID: 40739132
Nat Commun

Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18. [Abstract]

2025 Jul 2;16(1):6074. PMID: 40603850
Nat Commun

Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes. [Abstract]

2025 Apr 1;16(1):3131. PMID: 40169595
Nat Commun

CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer. [Abstract]

2025 Jan 9;16(1):541. PMID: 39788939
Nat Commun

Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice. [Abstract]

2022 Dec 16;13(1):7782. PMID: 36526632
Nat Commun

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress. [Abstract]

2022 Nov 17;13(1):7031. PMID: 36396642
Cell Death Differ

Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation. [Abstract]

2026 Jun 3. PMID: 42236908
Cell Death Differ

DR5/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma. [Abstract]

2026 Mar 23. PMID: 41872532
Cell Death Differ

GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM). [Abstract]

2026 Mar 5. PMID: 41787053
Cell Death Differ

The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma. [Abstract]

2025 Mar;32(3):506-520. PMID: 39478199
Cell Death Differ

Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells. [Abstract]

2024 Nov;31(11):1452-1466. PMID: 38987382
Cell Death Differ

PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy. [Abstract]

2024 Sep;31(9):1140-1156. PMID: 38816578
Cell Death Differ

The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma. [Abstract]

2023 Jul;30(7):1757-1770. PMID: 37173391
Bone Res

Pak4-mediated crosstalk between necroptotic macrophages and tendon stem/progenitor cells contributes to traumatic heterotopic ossification formation. [Abstract]

2025 Oct 20;13(1):88. PMID: 41111094
Bone Res

The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer. [Abstract]

2024 Aug 27;12(1):47. PMID: 39191757

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 27;12(1):47. [Abstract]

Cell death induced by HOXC10 inhibition plus TTI-101 cotreatment was rescued by ferroptosis inhibitors. Cells with or without knockdown of HOXC10 were pretreated with HOXC10 TTI-101 for 12 h and then treated the indicated cell death inhibitors (3-MA-1 mmol/L, Necrostatin-1-20 μmol/L, Ferrostatin-1-2 μmol/L, Z-VAD-FMK-10 μmol/L, Glutathione-1 mmol/L, Deferoxamine (DFO-100 μmol/L)) for an additional 72 h. Effect on ferroptosis inhibitors rescuing cell death was assessed by cell viability assays.
Acta Pharm Sin B

Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis. [Abstract]

2024 Aug;14(8):3493-3512. PMID: 39220878
Sci Transl Med

Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models. [Abstract]

2023 Jan 11;15(678):eabl7895. PMID: 36630483
Acta Pharm Sin B

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer. [Abstract]

2021 Jun;11(6):1513-1525. PMID: 34221865
Acta Pharm Sin B

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1. [Abstract]

2021 Dec;11(12):4045-4054. PMID: 35024325
Acta Pharm Sin B

Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma. [Abstract]

2021 May;11(5):1246-1260. PMID: 34094831

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2021 May;11(5):1246-1260. [Abstract]

Apoptosis of ECa109 and EC9706 cells treated with SFN (40 μM) and Z-VAD-FMK (20 μM) alone or combination for 48 h is analyzed by flow cytometry.
Autophagy

Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis. [Abstract]

2026 Feb 15:1-19. PMID: 41612599
Autophagy

Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy. [Abstract]

2026 Jan 19:1-16. PMID: 41518198
Autophagy

SENP2-mediated deSUMOylation of NCOA4 protects against ferritinophagy-dependent ferroptosis in myocardial ischemia-reperfusion injury. [Abstract]

2025 May 19:1-18. PMID: 40366738
Autophagy

Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury. [Abstract]

2025 Jul;21(7):1473-1491. PMID: 40000916
Autophagy

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication. [Abstract]

2023 Feb;19(2):551-569. PMID: 35670302
Adv Sci (Weinh)

ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling. [Abstract]

2026 Mar;13(16):e13310. PMID: 41589654
Adv Sci (Weinh)

Amodiaquine Enhances Anti-Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils. [Abstract]

2026 Jan 26:e15009. PMID: 41588921
Adv Sci (Weinh)

Novel Swelling-Lytic Cell Death Triggered by Cargo-Free Ionizable Lipid Nanoparticles. [Abstract]

2025 Aug 7:e09208. PMID: 40776529
Adv Sci (Weinh)

Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation. [Abstract]

2025 Jul 25:e08556. PMID: 40709550
Adv Sci (Weinh)

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer. [Abstract]

2025 Jan 31:e2408845. PMID: 39888307
Adv Sci (Weinh)

CHAC1 Mediates Endoplasmic Reticulum Stress-Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation. [Abstract]

2025 Jan 21:e2403992. PMID: 39836526
Adv Sci (Weinh)

Methuosis Inducer SGI-1027 Cooperates with Everolimus to Promote Apoptosis and Pyroptosis by Triggering Lysosomal Membrane Permeability in Renal Cancer. [Abstract]

2024 Aug 9:e2404693. PMID: 39119834
Adv Sci (Weinh)

Aloperine Suppresses Cancer Progression by Interacting with VPS4A to Inhibit Autophagosome-lysosome Fusion in NSCLC. [Abstract]

2024 Aug;11(31):e2308307. PMID: 39166458
Adv Sci (Weinh)

Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons Contributes to Host Defense. [Abstract]

2024 Jul 14:e2308890. PMID: 39004913
Adv Sci (Weinh)

Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer. [Abstract]

2023 Dec;10(36):e2303484. PMID: 37946697
Adv Sci (Weinh)

Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death. [Abstract]

2024 Jun 10:e2401396. PMID: 38859590
Adv Sci (Weinh)

Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia. [Abstract]

2024 Jun;11(21):e2309002. PMID: 38569496
Adv Sci (Weinh)

A Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture. [Abstract]

2024 May;11(20):e2305934. PMID: 38484186
Adv Sci (Weinh)

Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression. [Abstract]

2023 Aug;10(22):e2206798. PMID: 37330650
Adv Sci (Weinh)

IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death. [Abstract]

2021 Oct;8(19):e2101501. PMID: 34369094
Adv Sci (Weinh)

OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. [Abstract]

2021 Feb 8;8(8):2002874. PMID: 33898171

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. [Abstract]

In vitro growth of KYSE30 cells expressing EV or OTUD1 and treated with or without Z‐VAD-FMK (50 μM).

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. [Abstract]

Representative image and statistical analyses of JC‐1 staining of KYSE30 cells expressing EV or OTUD1 and treated with DDP or Z‐VAD-FMK (50 μM). Z‐VAD-FMK treatment could not completely inhibit the proapoptotic function of OTUD1.

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. [Abstract]

IB further confirmed the activation of the caspase‐dependent apoptotic pathway in OTUD1‐overexpressing cells with AIF ablation, which is diminished by VAD-FMK (50 μM).
Nat Chem Biol

Post-translational modifications orchestrate the intrinsic signaling bias of GPR52. [Abstract]

2025 Aug;21(8):1270-1282. PMID: 40087539
Theranostics

Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy. [Abstract]

2025 Jun 9;15(14):6665-6685. PMID: 40585993
Theranostics

Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK. [Abstract]

2020 Jun 19;10(17):7710-7729. PMID: 32685015

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jun 19;10(17):7710-7729. [Abstract]

When the cells were co-treated with Z-VAD-FMK (50 μM; 24 hours), the F-AgÅPs-induced inhibition of survival of 143B and SJSA-1 is significantly attenuated, as revealed by live/dead cell staining.
J Adv Res

SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo. [Abstract]

2025 Jul 12:S2090-1232(25)00545-4. PMID: 40659088
J Adv Res

Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway. [Abstract]

2025 Jan 25:S2090-1232(25)00059-1. PMID: 39870303
Exp Mol Med

RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc. [Abstract]

2025 Nov;57(11):2686-2698. PMID: 41310105
Biomaterials

A versatile nanoplatform carrying cascade Pt nanozymes remodeling tumor microenvironment for amplified sonodynamic/chemo therapy of thyroid cancer. [Abstract]

2024 Aug 26:313:122778. PMID: 39213978
Biomaterials

Natural bioactive lysosomes extracted from multiple cells for tumor therapy. [Abstract]

2024 Jan:304:122430. PMID: 38100907
Exp Mol Med

Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis. [Abstract]

2023 May;55(5):939-951. PMID: 37121969
Exp Mol Med

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy. [Abstract]

2022 Nov;54(11):2007-2021. PMID: 36385558
J Exp Clin Cancer Res

TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation. [Abstract]

2025 Dec 29;44(1):329. PMID: 41462308
J Exp Clin Cancer Res

Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer. [Abstract]

2023 Jun 19;42(1):150. PMID: 37337284
J Exp Clin Cancer Res

Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer. [Abstract]

2023 Jun 6;42(1):142. PMID: 37277863
J Exp Clin Cancer Res

L-kynurenine induces NK cell loss in gastric cancer microenvironment via promoting ferroptosis. [Abstract]

2023 Mar 1;42(1):52. PMID: 36855135
J Exp Clin Cancer Res

CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. [Abstract]

2022 Oct 20;41(1):307. PMID: 36266731
J Exp Clin Cancer Res

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer. [Abstract]

2021 Jun 23;40(1):206. PMID: 34162423
J Nanobiotechnology

Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer. [Abstract]

2025 Aug 12;23(1):562. PMID: 40797208
Carbohydr Polym

2025 Dec 10;376:124810.
Cell Discov

Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma. [Abstract]

2025 Oct 7;11(1):81. PMID: 41057295
Cell Discov

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy. [Abstract]

2025 Mar 11;11(1):22. PMID: 40064862
Sci Adv

Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitor. [Abstract]

2023 Oct 6;9(40):eadi6586. PMID: 37792941
Int J Oral Sci

MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts. [Abstract]

2023 Jan 16;15(1):7. PMID: 36646698
Small

Intranasal Zinc Oxide Nanoparticles Induce Neuronal PANoptosis via Microglial Pathway. [Abstract]

2025 Mar;21(12):e2408139. PMID: 40012250
J Biomed Sci

Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA. [Abstract]

2023 Nov 7;30(1):91. PMID: 37936170
Mol Ther

HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity. [Abstract]

2023 Feb 1;31(2):552-568. PMID: 36245126
Redox Biol

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. [Abstract]

2026 Mar:90:104043. PMID: 41604941
Redox Biol

LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer. [Abstract]

2025 Jun 7:85:103722. PMID: 40505346
Redox Biol

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. [Abstract]

2024 Dec 5:79:103460. PMID: 39657365
Redox Biol

SLC7A11 protects luminal A breast cancer cells against ferroptosis induced by CDK4/6 inhibitors. [Abstract]

2024 Aug 10:76:103304. PMID: 39153252
Redox Biol

Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis. [Abstract]

2024 Jun:72:103157. PMID: 38631119
Redox Biol

Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer. [Abstract]

2022 Aug 4;55:102426. PMID: 35963119
Redox Biol

Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation. [Abstract]

2022 Oct;56:102435. PMID: 36029649

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct;56:102435. [Abstract]

Primary HSCs and LX-2 cells are treated with EA (LX-2 cells: 40 μM; primary HSCs: 45 μM), Ferrostatin-1 (1 μM) and Z-VAD-FMK (10 μM), and cells are stained with PI (red fluorescence) to examine the dead cells.
Redox Biol

Cationic antimicrobial peptide NRC-03 induces oral squamous cell carcinoma cell apoptosis via CypD-mPTP axis-mediated mitochondrial oxidative stress. [Abstract]

2022 Aug;54:102355. PMID: 35660629

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Aug;54:102355. [Abstract]

In CAL-27 cells, Z-VAD-FMK (50 μM; 4 hours) treatment counteracted the NRC-03-induced cytotoxicity and apoptosis.
Redox Biol

FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells. [Abstract]

2021 Jan;38:101807. PMID: 33271455
J Control Release

Inducing potent ferroptosis in cancer cells by manipulation of ferritinophagy with a ferritin-targeted ATTEC. [Abstract]

2025 Nov 20:389:114450. PMID: 41274571
J Hazard Mater

Cadmium exposure is associated with impaired ovarian function: Potential role of cadmium-induced ferroptosis in granulosa cells. [Abstract]

2026 Feb 1:503:141148. PMID: 41548307
Gut Microbes

PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation. [Abstract]

2023 Dec;15(2):2265578. PMID: 37800577
EBioMedicine

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis. [Abstract]

2022 Oct;84:104258. PMID: 36137413
EBioMedicine

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. [Abstract]

2021 Jul;69:103456. PMID: 34233258
MedComm

Antiferroptosis therapy alleviated the development of atherosclerosis. [Abstract]

2024 Apr 4;5(4):e520. PMID: 38576455
MedComm (2020)

Sertaconazole provokes proapoptotic autophagy via stabilizing TRADD in nonsmall cell lung cancer cells. [Abstract]

2021 Dec 16;2(4):821-837. PMID: 34977879
J Exp Med

Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1. [Abstract]

2026 Jan 5;223(1):e20250603. PMID: 41081715
Cell Rep Med

Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis. [Abstract]

2025 Sep 25:102371. PMID: 41005298
J Immunother Cancer

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma. [Abstract]

2024 Nov 24;12(11):e009805. PMID: 39581704
Pharmacol Res

GSTA1/CTNNB1 axis facilitates sorafenib resistance via suppressing ferroptosis in hepatocellular carcinoma. [Abstract]

2024 Nov 5:210:107490. PMID: 39510148
Pharmacol Res

Developing patient-derived organoids to demonstrate JX24120 inhibits SAMe synthesis in endometrial cancer by targeting MAT2B. [Abstract]

2024 Sep 16:107420. PMID: 39293586
Pharmacol Res

3'-epi-12β-hydroxyfroside-mediated autophagy degradation of RIPK1/RIPK3 necrosomes leads to anergy of immunogenic cell death in triple-negative breast cancer cells. [Abstract]

2023 Jan:187:106613. PMID: 36535569
Clin Cancer Res

Genomic Subtype Influences BH3 Mimetic Drug Sensitivity and Synergy with Cytotoxic Chemotherapeutics in T-cell Acute Lymphoblastic Leukemia. [Abstract]

2026 Apr 17:10.1158/1078-0432.CCR-25-4836. PMID: 41995729
Mater Today Bio

SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse. [Abstract]

2025 Nov 13:35:102547. PMID: 41322137
Cell Mol Biol Lett

RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis. [Abstract]

2025 Oct 2;30(1):109. PMID: 41039223
Clin Cancer Res

UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma. [Abstract]

2025 Jul 8. PMID: 40627452
Clin Cancer Res

IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy. [Abstract]

2024 Jun 3;30(11):2558-2570. PMID: 38578278
Cancer Lett

SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis. [Abstract]

2025 Apr 16:217726. PMID: 40250791
Cancer Lett

A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma. [Abstract]

2024 Jun 28:217092. PMID: 38945202
Cancer Lett

Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma. [Abstract]

2024 May 1:589:216811. PMID: 38490328
Cancer Lett

Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization. [Abstract]

2024 Apr 10:587:216732. PMID: 38360142
Mol Biomed

Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma. [Abstract]

2023 Nov 17;4(1):42. PMID: 37975957
Cancer Lett

TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis. [Abstract]

2022 Aug 10:541:215752. PMID: 35644286
Cancer Lett

UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer. [Abstract]

2021 Oct 28;519:2-19. PMID: 34161791
Cancer Lett

SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition. [Abstract]

2021 Jul 10;510:93-104. PMID: 33872694
Cancer Lett

Prodigiosin impairs autophagosome-lysosome fusion that sensitizes colorectal cancer cells to 5-fluorouracil-induced cell death. [Abstract]

2020 Jul 1;481:15-23. PMID: 32184145
Int J Biol Sci

Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy. [Abstract]

2024 Apr 29;20(7):2658-2685. PMID: 38725851
Int J Biol Sci

Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation. [Abstract]

2023 Feb 27;19(5):1471-1489. PMID: 37056925
Int J Biol Sci

O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis. [Abstract]

2022 Jun 21;18(10):4135-4150. PMID: 35844792
Int J Biol Sci

Phosphoinositide specific phospholipase Cγ1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro. [Abstract]

2020 Feb 21;16(8):1427-1440. PMID: 32210730
Food Chem

Fish oil nano-emulsion kills macrophage: Ferroptosis triggered by catalase-catalysed superoxide eruption. [Abstract]

2023 May 15:408:135249. PMID: 36566546
J Colloid Interface Sci

Orchestrating apoptosis and ferroptosis through enhanced sonodynamic therapy using amorphous UIO-66-CoOx. [Abstract]

2024 Aug:667:91-100. PMID: 38621335
J Colloid Interface Sci

Interfacial strong interaction-enabling cascade nanozymes for apoptosis-ferroptosis synergistic therapy. [Abstract]

2024 Jan;653(Pt A):20-29. PMID: 37708728
Mater Today Phys

2023 Aug, 36, 101150.
Acta Biomater

Endoplasmic reticulum-targeting prodrug nanoassemblies for potent ferroptosis therapy via concurrent glutathione depletion and arachidonic acid accumulation. [Abstract]

2026 Apr:214:542-556. PMID: 41819459
Cell Death Dis

IFI16 is essential to linking DNA damage and ferroptosis in acute kidney injury. [Abstract]

2026 Mar 23;17(1):350. PMID: 41872158
Cell Death Dis

SETD7-mediated H3K4me1 activates ALDH1A3 to drive ferroptosis resistance in esophageal squamous cell carcinoma. [Abstract]

2025 Nov 7;16(1):810. PMID: 41203594
Cell Death Dis

RIPK3 promotes skin inflammation by enhancing IL-36α signaling and necroptosis in keratinocytes. [Abstract]

2025 Oct 24;16(1):759. PMID: 41136377
Adv Healthc Mater

Tumor Microenvironment-Responsive Hydrogen-Generating Zn-Doped ReZIF-8 Nanoplatform for Enhanced Tumor Suppression. [Abstract]

2025 Sep 13:e02489. PMID: 40944582
Cell Death Dis

DJ-1 counteracts Caveolin-1-mediated necroptosis to inhibit epithelial barrier dysfunction in colitis. [Abstract]

2025 Aug 29;16(1):657. PMID: 40877233
Cell Death Dis

ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA. [Abstract]

2025 Jul 23;16(1):549. PMID: 40695795
Cell Death Dis

Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore. [Abstract]

2025 Jul 1;16(1):482. PMID: 40592836
Cell Death Dis

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. [Abstract]

2025 Jun 17;16(1):452. PMID: 40523886
Cell Death Dis

BCAT2 binding to PCBP1 regulates the PI3K/AKT signaling pathway to inhibit autophagy-related apoptosis and ferroptosis in prostate cancer. [Abstract]

2025 Apr 24;16(1):337. PMID: 40274762
Cell Death Dis

Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer. [Abstract]

2025 Apr 5;16(1):254. PMID: 40185704
Cell Death Dis

Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest. [Abstract]

2024 Nov 15;15(11):834. PMID: 39548081
Cell Death Dis

TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis. [Abstract]

2024 Dec 21;15(12):925. PMID: 39709491
Cell Death Dis

PBLD promotes IRF3 mediated the type I interferon (IFN-I) response and apoptosis to inhibit viral replication. [Abstract]

2024 Oct 3;15(10):727. PMID: 39362857
Cell Death Dis

NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function. [Abstract]

2024 Oct 18;15(10):759. PMID: 39424623
Cell Death Dis

Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4. [Abstract]

2024 Oct 5;15(10):729. PMID: 39368999
Cell Death Dis

The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis. [Abstract]

2024 Aug 19;15(8):600. PMID: 39160159
Cell Death Dis

Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers. [Abstract]

2024 Feb 16;15(2):149. PMID: 38365764
Cell Death Dis

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex. [Abstract]

2023 Nov 25;14(11):767. PMID: 38007473
Cell Death Dis

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4. [Abstract]

2023 Jan 31;14(1):74. PMID: 36720852
Cell Death Dis

Whole transcriptome and proteome analyses identify potential targets and mechanisms underlying tumor treating fields against glioblastoma. [Abstract]

2022 Aug 18;13(8):721. PMID: 35982032
Cell Death Dis

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity. [Abstract]

2022 Jul 4;13(7):579. PMID: 35787614
Cell Death Dis

sGRP78 enhances selective autophagy of monomeric TLR4 to regulate myeloid cell death. [Abstract]

2022 Jul 7;13(7):587. PMID: 35798718
Cell Death Dis

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury. [Abstract]

2022 May 30;13(5):507. PMID: 35637215
Cell Death Dis

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. [Abstract]

2022 May 20;13(5):479. PMID: 35595754
Cell Death Dis

Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury. [Abstract]

2022 Feb 25;13(2):188. PMID: 35217652
Cell Death Dis

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia. [Abstract]

2021 Dec 14;12(12):1159. PMID: 34907173
Cell Death Dis

Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway. [Abstract]

2021 Aug 27;12(9):815. PMID: 34453041
Cell Death Dis

Utidelone inhibits growth of colorectal cancer cells through ROS/JNK signaling pathway. [Abstract]

2021 Apr 1;12(4):338. PMID: 33795638
Cell Death Dis

Preclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia. [Abstract]

2020 Sep 18;11(9):778. PMID: 32948748
Acta Biomater

Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma. [Abstract]

2020 Jun;109:229-243. PMID: 32294550

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Acta Biomater. 2020 Jun;109:229-243. [Abstract]

The decreased cleaved caspase-3 and Bax proteins showed that Z-VAD successfully inhibited Chemo-PDT induced apoptosis.
Cell Death Dis

"Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis. [Abstract]

2020 Mar 13;11(3):183. PMID: 32170066
Cell Death Dis

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP. [Abstract]

2019 Sep 20;10(10):700. PMID: 31541082
Sci China Life Sci

Targeting methionine-induced pyroptosis enhances anti-tumor immunity. [Abstract]

2026 May;69(5):1604-1619. PMID: 41793590
Sci China Life Sci

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis. [Abstract]

2025 Jan;68(1):204-218. PMID: 39245684
Sci China Life Sci

Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure. [Abstract]

2024 Feb;67(2):360-378. PMID: 37815699
CCS Chem

20 Jul 2021.
Proc Natl Acad Sci U S A

METTL3-mediated N6-methyladenosine modification of Dnajb1 modulates cardiomyocyte ferroptosis during myocardial infarction. [Abstract]

2026 Mar 10;123(10):e2529187123. PMID: 41774801
J Cachexia Sarcopenia Muscle

C2C12-Derived ApoVs Promote Skeletal Muscle Development and Ameliorate Age-Related Muscle Loss Through Igf1r/PI3K/AKT/mTOR Pathway. [Abstract]

2025 Dec;16(6):e70159. PMID: 41344911
Proc Natl Acad Sci U S A

Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways. [Abstract]

2025 Mar 11;122(10):e2419620122. PMID: 40035769
Proc Natl Acad Sci U S A

Activation of P53 pathway contributes to Xenopus hybrid inviability. [Abstract]

2023 May 23;120(21):e2303698120. PMID: 37186864
Proc Natl Acad Sci U S A

The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11. [Abstract]

2022 Nov 8;119(45):e2210809119. PMID: 36322773
Nano Res

2026.
Nano Res

2025 Oct.
Osteoarthritis Cartilage

Chondrocyte apoptosis in temporomandibular joint osteoarthritis promotes bone resorption by enhancing chemotaxis of osteoclast precursors. [Abstract]

2022 Aug;30(8):1140-1153. PMID: 35513247
Cell Commun Signal

NSP1 of Alongshan virus antagonizes type I interferon responses by promoting STUB1-mediated degradation of RIG-I. [Abstract]

2026 Mar 24;24(1):262. PMID: 41877189
Cell Commun Signal

Off-target engagement of sotorasib with PPARγ via FABP4: a novel mechanism driving interstitial lung disease. [Abstract]

2025 Oct 2;23(1):416. PMID: 41039446
Cell Commun Signal

Phosphorylated IRF3 promotes GSDME-mediated pyroptosis through RIPK1/FADD/caspase-8 complex formation during mitotic arrest in ovarian cancer. [Abstract]

2025 Jul 1;23(1):306. PMID: 40597187
J Pharm Anal

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52. [Abstract]

2024 Jan;14(1):86-99. PMID: 38352945
J Pharm Anal

Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma. [Abstract]

2023 May;13(5):463-482. PMID: 37305788
Dev Cell

Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma. [Abstract]

2025 Mar 20:S1534-5807(25)00121-2. PMID: 40132584
Dev Cell

GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. [Abstract]

2024 Jul 3:S1534-5807(24)00385-X. PMID: 38981469
Int J Biol Macromol

Light-crosslinked gelatin methacrylate hydrogel prevents intervertebral disc degeneration by delivering 10-hydroxy-2-decenoic acid to inhibit ferroptosis via NF-κB signaling. [Abstract]

2025 Oct 21;331(Pt 2):148454. PMID: 41130468
Int J Biol Macromol

Heme oxygenase-1 (HO-1) depletion promotes ferroptosis to reverse cisplatin-resistance via enhancing NCOA4-mediated ferritinophagy in ovarian cancer. [Abstract]

2025 Sep 2;327(Pt 2):147257. PMID: 40907917
VIEW

2025 May 25.
Int J Biol Macromol

Molecular mechanisms underlying the anti-Colon Cancer effects of Caulerpa lentillifera polysaccharides (CLP). [Abstract]

2025 Mar 27:142594. PMID: 40157667
Int J Biol Macromol

Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease. [Abstract]

2023 Jul 31:244:125373. PMID: 37327932
Acta Pharmacol Sin

KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis. [Abstract]

2025 Mar 27. PMID: 40148674
Acta Pharmacol Sin

Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Feb;42(2):301-310. PMID: 32699265
Acta Pharmacol Sin

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. [Abstract]

2021 Jan;42(1):160-170. PMID: 32541921
Phytomedicine

Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway. [Abstract]

2026 Jun:155:158126. PMID: 41931998
Phytomedicine

Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells. [Abstract]

2026 May:154:158057. PMID: 41833103
Phytomedicine

Nuciferine ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting BMSCs ferroptosis via HIF-1α. [Abstract]

2026 Jun:155:158070. PMID: 41861683
Phytomedicine

Baohuoside I induces GSDME-dependent pyroptosis and synergistically inhibits lung adenocarcinoma with cisplatin. [Abstract]

2026 Apr:153:157899. PMID: 41643445
Phytomedicine

Lupenone regulates LOXL2-mediated PANoptosis signaling through E3 ubiquitin ligases RNF168 to improve radiation-induced lung injury. [Abstract]

2026 Apr:153:157983. PMID: 41722124
Phytomedicine

Anti-tumor effects of Guggulsterone in osteosarcoma: Role of SIRT3-mediated PINK1-Parkin mitophagy activation. [Abstract]

2026 Jan 20:153:157860. PMID: 41650525
Phytomedicine

Celastrol induces ferroptosis in ccRCC through TEF-Driven ACOX2 upregulation and metabolic reprogramming. [Abstract]

2026 Mar:152:157884. PMID: 41619549
Phytomedicine

Andrographolide induces ferroptosis in colorectal cancer via P53-mediated downregulation of the SLC7A11/GPX4 signaling pathway. [Abstract]

2025 Nov 25:148:157470. PMID: 41187650
Phytomedicine

Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition. [Abstract]

2025 Nov 29:150:157633. PMID: 41351983
Phytomedicine

Cinobufagin overcomes bortezomib resistance in multiple myeloma strains by targeting SEC62/TRPM4-mediated NECSO. [Abstract]

2025 Aug 16:147:157171. PMID: 40839992
Phytomedicine

Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer. [Abstract]

2025 Oct:146:157117. PMID: 40812220
Phytomedicine

Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis. [Abstract]

2025 May 28:143:156925. PMID: 40456202
Phytomedicine

Picropodophyllin induces ferroptosis via blockage of AKT/NRF2/SLC7A11 and AKT/NRF2/SLC40A1 axes in hepatocellular carcinoma as a natural IGF1R inhibitor. [Abstract]

2025 May 10:143:156840. PMID: 40412057
Phytomedicine

Tanshinone IIA promotes ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of PTGS2 expression. [Abstract]

2025 Apr 5:141:156702. PMID: 40222167
Phytomedicine

The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-Src-YAP/TAZ-TFRC axis. [Abstract]

2025 Apr 24:142:156804. PMID: 40311597
EMBO Mol Med

Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke. [Abstract]

2025 Apr;17(4):679-695. PMID: 40021931
Phytomedicine

Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis. [Abstract]

2025 Jan 25:139:156417. PMID: 39923427
Phytomedicine

Ginsenoside compound K alleviates brain aging by inhibiting ferroptosis through modulation of the ASK1-MKK7-JNK signaling pathway. [Abstract]

2024 Nov 10:135:156239. PMID: 39547099
Phytomedicine

β,β-Dimethylacrylalkannin, a key component of Zicao, induces cell cycle arrest and necrosis in hepatocellular carcinoma cells. [Abstract]

2024 Aug 19:134:155959. PMID: 39178682
Phytomedicine

Ethanol extract of Eclipta prostrata induces multiple myeloma ferroptosis via Keap1/Nrf2/HO-1 axis. [Abstract]

2024 Jun:128:155401. PMID: 38507850
Phytomedicine

The kava chalcone flavokawain B exerts inhibitory activity and synergizes with BCL-2 inhibition in malignant B-cell lymphoma. [Abstract]

2023 Nov:120:155074. PMID: 37716033
Phytomedicine

Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib. [Abstract]

2023 Mar:111:154668. PMID: 36657316
Phytomedicine

A novel sesquiterpene lactone fraction from Eupatorium chinense L. suppresses hepatocellular carcinoma growth by triggering ferritinophagy and mitochondrial damage. [Abstract]

2023 Apr:112:154671. PMID: 36773432
Phytomedicine

Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis. [Abstract]

2023 Jan:109:154593. PMID: 36610113
EMBO J

Stearate-derived very long-chain fatty acids are indispensable to tumor growth. [Abstract]

2023 Jan 16;42(2):e111268. PMID: 36408830
ACS Appl Mater Interfaces

Co-disruption of GPX4 and DHODH Ferroptosis Defense Systems via Excipient-Free Self-Assembled Nanoassemblies for Enhanced Ferroptosis Therapy in Triple-Negative Breast Cancer. [Abstract]

2026 Feb 18;18(6):9471-9482. PMID: 41645812
Free Radic Biol Med

Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. [Abstract]

2026 Mar 16:246:35-50. PMID: 41520847
Free Radic Biol Med

Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation. [Abstract]

2025 Dec 15:244:284-295. PMID: 41407052
ACS Appl Mater Interfaces

Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment. [Abstract]

2025 Dec 17;17(50):67595-67608. PMID: 41348354
ACS Appl Mater Interfaces

DNA Tetrahedron Nanodevice as a Co-delivery Vehicle of Shikonin and CpG Oligonucleotide for Enhanced Triple-Negative Breast Cancer Chemoimmunotherapy. [Abstract]

2025 Aug 6;17(31):44803-44815. PMID: 40720260
Free Radic Biol Med

Dehydroascorbic acid impairs neurite growth through RIPK1-associated caspase activation. [Abstract]

2025 Nov:239:406-416. PMID: 40730291
Free Radic Biol Med

Glucose-6-phosphate dehydrogenase (G6PD) shields pancreatic cancer from autophagy-dependent ferroptosis by suppressing redox imbalance induced AMPK/mTOR signaling. [Abstract]

2025 Sep:237:195-209. PMID: 40466783
Free Radic Biol Med

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]

2025 Aug 1:235:231-247. PMID: 40316059
Free Radic Biol Med

Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium. [Abstract]

2025 Feb 16:228:173-182. PMID: 39761766
Free Radic Biol Med

Targeting PGAM5 attenuates airway inflammation in asthma by inhibiting HMGB1 release in bronchial epithelium. [Abstract]

2025 Feb 16:228:207-220. PMID: 39756489
Free Radic Biol Med

LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction. [Abstract]

2024 Nov 8:226:29-42. PMID: 39522565
Free Radic Biol Med

Crucial roles of asprosin in cisplatin-induced ferroptosis and acute kidney injury. [Abstract]

2024 Dec 9:227:296-311. PMID: 39653130
ACS Appl Mater Interfaces

Nanozymes as Glucose Scavengers and Oxygenerators for Enhancing Tumor Radiotherapy. [Abstract]

2024 Nov 13;16(45):61805-61819. PMID: 39480068
Part Fibre Toxicol

Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage. [Abstract]

2024 Mar 7;21(1):13. PMID: 38454452
Free Radic Biol Med

Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction. [Abstract]

2024 Mar:214:193-205. PMID: 38369075
Free Radic Biol Med

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]

2024 Mar:213:150-163. PMID: 38190923
Free Radic Biol Med

Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. [Abstract]

2023 Jul:203:86-101. PMID: 37044150
Free Radic Biol Med

Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway. [Abstract]

2023 May 20:201:76-88. PMID: 36933812
Part Fibre Toxicol

Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation. [Abstract]

2020 Sep 18;17(1):46. PMID: 32948194
Apoptosis

AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure. [Abstract]

2025 Jul 23. PMID: 40702248
Apoptosis

LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. [Abstract]

2023 Feb;28(1-2):186-198. PMID: 36282364
NPJ Sci Food

Umami induces pulmonary epithelial senescence via L-glutamic acid-triggered minority MOMP. [Abstract]

2026 Mar 2;10(1):125. PMID: 41771900
J Orthop Translat

SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound. [Abstract]

2025 Apr 25:52:233-248. PMID: 40337549
Br J Pharmacol

A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death. [Abstract]

2025 May 13. PMID: 40356419
Sens Actuators B Chem

2024 Nov 1.
Br J Pharmacol

Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling and enhances the anti-tumour action of paclitaxel. [Abstract]

2024 May 7. PMID: 38715438
J Transl Med

Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer. [Abstract]

2025 Aug 5;23(1):860. PMID: 40764992
J Transl Med

Siramesine induced cell death of glioblastoma through inactivating the STAT3-MGMT signaling pathway. [Abstract]

2025 Jul 10;23(1):780. PMID: 40640878
J Transl Med

Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis. [Abstract]

2025 Feb 28;23(1):247. PMID: 40022222
J Transl Med

YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression. [Abstract]

2024 Dec 27;22(1):1153. PMID: 39731187
Biomed Pharmacother

Gingerenone A induces ferroptosis in colorectal cancer via targeting suppression of SLC7A11 signaling pathway. [Abstract]

2024 Nov:180:117529. PMID: 39393329
J Transl Med

Cancer cell-selective induction of mitochondrial stress and immunogenic cell death by PT-112 in human prostate cell lines. [Abstract]

2024 Oct 11;22(1):927. PMID: 39394618
J Transl Med

Mitochondrial GCN5L1 acts as a novel regulator for iron homeostasis to promote sorafenib sensitivity in hepatocellular carcinoma. [Abstract]

2024 Jun 25;22(1):593. PMID: 38918793
Biomed Pharmacother

Matrine induces autophagic cell death by triggering ROS/AMPK/mTOR axis and apoptosis in multiple myeloma. [Abstract]

2024 May 16:175:116738. PMID: 38759291
Biomed Pharmacother

Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes. [Abstract]

2024 May 10:175:116727. PMID: 38733771
J Transl Med

CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial-mesenchymal transition, G2/M phase transition, and PANoptosis. [Abstract]

2022 Oct 2;20(1):444. PMID: 36184616
Biomed Pharmacother

Regulatory mechanism of α-hederin upon cisplatin sensibility in NSCLC at safe dose by destroying GSS/GSH/GPX2 axis-mediated glutathione oxidation-reduction system. [Abstract]

2022 Jun;150:112927. PMID: 35398749
Biomed Pharmacother

Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation. [Abstract]

2021 Dec:144:112297. PMID: 34649218
Redox Rep

The hippo-YAP1/TEAD1-SLC7A5 axis: uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosis. [Abstract]

2026 Dec;31(1):2643967. PMID: 41833934
Redox Rep

Prophylactic quercetin administration attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells. [Abstract]

2026 Dec;31(1):2632434. PMID: 41697789
Redox Rep

Tramadol induced hypoxia signaling and paraptosis-like cell death in breast cancer cells via HIF-1α and ATF4 dependent pathways. [Abstract]

2026 Dec;31(1):2588866. PMID: 41526224
Redox Rep

The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress. [Abstract]

2025 Dec;30(1):2588086. PMID: 41292488
Food Sci Hum Wellness

2025.
Cell Mol Gastroenterol Hepatol

Vitamin D receptor activation targets ROS-mediated crosstalk between autophagy and apoptosis in hepatocytes in cholestasis mice. [Abstract]

2023;15(4):887-901. PMID: 36280140
Oncogene

DNA replication stress and translational repression converge to drive CDK1- and caspase-dependent apoptosis in Ewing sarcoma. [Abstract]

2026 Jun 10. PMID: 42270776
Oncogene

Identification of RAPGEF3 as the therapeutic vulnerability of basal-subtype lung squamous cell carcinoma. [Abstract]

2025 Sep;44(34):3142-3148. PMID: 40781157
Chin Med J (Engl)

Erianin induces GSDMD-dependent pyroptosis and synergistically enhances doxorubicin efficacy via the PI3K/AKT signaling pathway in diffuse large B-cell lymphoma. [Abstract]

2025 Aug 20. PMID: 40830921
Stem Cell Res Ther

Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia-reperfusion injury by inhibiting ferroptosis via GPX4. [Abstract]

2025 Feb 21;16(1):81. PMID: 39985001
Oncogene

CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis. [Abstract]

2025 Jun;44(22):1678-1693. PMID: 40089640
Oncogene

SGK1 suppresses ferroptosis in ovarian cancer via NRF2-dependent and -independent pathways. [Abstract]

2024 Nov;43(45):3335-3347. PMID: 39306614
Stem Cell Res Ther

Adipose-derived stem cells apoptosis rejuvenate radiation-impaired skin in mice via remodeling and rearranging dermal collagens matrix. [Abstract]

2024 Sep 27;15(1):324. PMID: 39334464
Oncogene

PPM1D activity promotes cellular transformation by preventing senescence and cell death. [Abstract]

2024 Oct;43(42):3081-3093. PMID: 39237765
Chin Med J (Engl)

Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells. [Abstract]

2023 Sep 20;136(18):2210-2220. PMID: 37488674
Blood Adv

Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis. [Abstract]

2022 Aug 23;6(16):4847-4858. PMID: 35820018
Int Endod J

Inhibition of receptor-interacting protein kinase-3 in the necroptosis pathway attenuates inflammatory bone loss in experimental apical periodontitis in Balb/c mice. [Abstract]

2021 Sep;54(9):1538-1547. PMID: 33896018
Cell Death Discov

Targeting integrin beta 4 in diacetyl-induced anoikis of the airway epithelium. [Abstract]

2026 Feb 26. PMID: 41741435
Cell Death Discov

PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2. [Abstract]

2026 Feb 23;12(1):105. PMID: 41724793
Cell Death Discov

Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phospho)lipid peroxidation as a potential therapeutic strategy. [Abstract]

2025 Nov 28;11(1):552. PMID: 41315180
Cell Death Discov

SLC25A10 promotes cisplatin resistance by inhibiting ferroptosis in cervical cancer. [Abstract]

2025 Oct 7;11(1):447. PMID: 41057306
J Autoimmun

Effect of opioid receptor antagonist on mitigating tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-induced apoptolysis in pemphigus pathogenesis. [Abstract]

2024 Sep 13:149:103307. PMID: 39276627
Cell Death Discov

MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1. [Abstract]

2024 Aug 13;10(1):363. PMID: 39138167
Cell Death Discov

Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells. [Abstract]

2024 Mar 12;10(1):134. PMID: 38472168
Cell Death Discov

RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells. [Abstract]

2024 Mar 23;10(1):152. PMID: 38521771
Cell Death Discov

Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage. [Abstract]

2024 Mar 11;10(1):130. PMID: 38467618
Cell Death Discov

Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer. [Abstract]

2024 Jan 23;10(1):42. PMID: 38263152
Cell Death Discov

Engineered small extracellular vesicles loaded with miR-654-5p promote ferroptosis by targeting HSPB1 to alleviate sorafenib resistance in hepatocellular carcinoma. [Abstract]

2023 Sep 30;9(1):362. PMID: 37777559
Cell Death Discov

NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis. [Abstract]

2023 Aug 15;9(1):297. PMID: 37582760
Cell Death Discov

Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. [Abstract]

2023 Aug 14;9(1):296. PMID: 37580343
Cell Death Discov

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation. [Abstract]

2023 Aug 25;9(1):311. PMID: 37626043
J Autoimmun

zVAD alleviates experimental autoimmune hepatitis in mice by increasing the sensitivity of macrophage to TNFR1-dependent necroptosis. [Abstract]

2022 Dec:133:102904. PMID: 36108506

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: J Autoimmun. 2022 Dec:133:102904. [Abstract]

C57BL/6 are treated with Concanavalin A (12 μg/g) alone or zVAD (20 μg/g) alone or zVAD (20 μg/g) + Concanavalin A (12 μg/g) at indicated times. The number of apoptotic cells in the zVAD + Concanavalin A treated group is markedly reduced compared with that observed in the ConA-treated group.

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: J Autoimmun. 2022 Dec:133:102904. [Abstract]

After being treated with zVAD (0, 20, 40, 80 μM) for 30 min, the BMDMs are followed by the administration of LPS (100 ng/ml) for 24 h.

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: J Autoimmun. 2022 Dec:133:102904. [Abstract]

The BMDMs are cultured with different concentrations of zVAD (0, 20, 40, 80, 100 μM) for 24 h.
Cell Death Discov

Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways. [Abstract]

2021 Sep 13;7(1):239. PMID: 34518510
Cell Rep

circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis. [Abstract]

2025 Dec 5;44(12):116659. PMID: 41351835
Cell Rep

Mask protein keeps NF-κB precursor inactive by inducing a closed conformation and isolating it in biomolecular condensates. [Abstract]

2025 Sep 3;44(9):116225. PMID: 40911418
Cell Rep

TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation. [Abstract]

2025 Aug 21;44(9):116186. PMID: 40844875
Cell Rep

The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis. [Abstract]

2025 Jul 26;44(8):116076. PMID: 40716062
Cell Rep

Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis. [Abstract]

2024 Jul 9;43(7):114477. PMID: 38985676
Cell Rep

ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation. [Abstract]

2023 Mar 17;42(3):112278. PMID: 36933219
Cell Rep

Structural basis for sterol sensing by Scap and Insig. [Abstract]

2021 Jun 29;35(13):109299. PMID: 34192549
Appl Mater Today

2021, 101027.
Br J Cancer

Senescence-related gene signature predicts prostate cancer progression and identifies PCNA as a therapeutic target via multi-omics machine learning integration. [Abstract]

2025 Dec 18. PMID: 41407876
J Med Chem

Development and Preclinical Evaluation of Novel F-18-Labeled Dihydropyrazole RIPK1 PET Tracers for Neuroinflammation Imaging. [Abstract]

2025 Dec 11;68(23):25590-25606. PMID: 41266996
J Med Chem

Discovery of a 1 H-Pyrazol-3-Amine Derivative as a Novel, Selective, and Orally Available RIPK1 Inhibitor for the Treatment of Inflammatory Disease. [Abstract]

2025 Oct 23;68(20):21766-21785. PMID: 41077763
Clin Transl Med

Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4. [Abstract]

2025 Feb;15(2):e70221. PMID: 39902679
Clin Transl Med

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation. [Abstract]

2023 Jun;13(6):e1300. PMID: 37337470
Clin Transl Med

Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies. [Abstract]

2023 Mar;13(3):e1229. PMID: 36959764
J Med Chem

A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species. [Abstract]

2020 Sep 10;63(17):9838-9855. PMID: 32809827
J Med Chem

Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy. [Abstract]

2019 Oct 10;62(19):8760-8772. PMID: 31509699
Neural Regen Res

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury. [Abstract]

2025 Nov 1;20(11):3273-3286. PMID: 38993124
Int J Nanomedicine

Intravenous Injection of Na Ions Aggravates Ang II-Induced Hypertension-Related Vascular Endothelial Injury by Increasing Transmembrane Osmotic Pressure. [Abstract]

2023 Dec 11:18:7505-7521. PMID: 38106448
Int J Radiat Oncol Biol Phys

Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma. [Abstract]

2023 Nov 15;117(4):966-978. PMID: 37244629
Inorg Chem Front

Structural variations in the trans-carboxylate/chlorido axis that impact the mode of action of Pt(ii) complexes. [Abstract]

2025 May 12. PMID: 40487752
Mol Med

Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway. [Abstract]

2023 Oct 25;29(1):144. PMID: 37880599
Phytother Res

4'-Hydroxychalcone Induces Ferroptosis in Glioblastoma Through the xCT/GSH/GPX4 Axis Under the Regulation of the AKT/mTORC1/4EBP1 Pathway. [Abstract]

2025 Aug 25. PMID: 40855403
Oncoimmunology

Smad7 is a negative regulator of immunogenic cell death in colorectal cancer. [Abstract]

2025 Dec;14(1):2490346. PMID: 40213961
Phytother Res

Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of MAPK and downregulation of the mTOR-Beclin1 signalling cascade. [Abstract]

2023 Feb;37(2):689-701. PMID: 36245270

Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Phytother Res. 2023 Feb;37(2):689-701. [Abstract]

z-VAD-fmk (5 μM; 4 h) weakens CDBEE-induced apoptosis in MGC-803 and HGC-27 cells.
Phytother Res

6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway. [Abstract]

2023 Jan;37(1):124-139. PMID: 36116140
Phytother Res

Curcumol simultaneously induces both apoptosis and autophagy in human nasopharyngeal carcinoma cells. [Abstract]

2021 Dec;35(12):7004-7017. PMID: 34750896
Cell Mol Life Sci

Prolyl endopeptidase is a multifunctional host factor required for FMDV infection. [Abstract]

2025 Nov 19;82(1):408. PMID: 41258568
J Agric Food Chem

Ginsenoside RK1 Promotes Hepatic Stellate Cell Glycolysis-Mediated Ferroptosis by Activating the HK2/ACSL4/LPCAT3/ALOX5 Signaling Pathway. [Abstract]

2025 Jul 9;73(27):17205-17218. PMID: 40570179
EMBO Rep

HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43. [Abstract]

2024 Oct;25(10):4337-4357. PMID: 39242776
EMBO Rep

RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation. [Abstract]

2024 Oct;25(10):4594-4624. PMID: 39285245
Cell Mol Life Sci

S100A8/A9-activated IFNγ+ NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis. [Abstract]

2024 Aug 12;81(1):345. PMID: 39133305
Cell Mol Life Sci

Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2. [Abstract]

2024 Jul 30;81(1):325. PMID: 39079969
J Agric Food Chem

Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4. [Abstract]

2024 Mar 27;72(12):6178-6188. PMID: 38483540
J Agric Food Chem

Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance. [Abstract]

2023 Feb 8. PMID: 36752041
J Agric Food Chem

A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. [Abstract]

2023 Feb 15;71(6):2745-2761. PMID: 36719855
Ecotoxicol Environ Saf

Hydramethylnon-induced pulmonary toxicity associated with necroptosis signaling and mitochondrial dysfunction in human bronchial epithelial cells. [Abstract]

2026 Jun 5:322:120317. PMID: 42248040
JCI Insight

Mitochondrial metabolic rewiring sensitizes mTORC1 inhibitor persister cells to cuproptosis. [Abstract]

2025 Nov 24;10(22):e187448. PMID: 41277553
Ecotoxicol Environ Saf

Lycopene inhibits zearalenone-induced ferroptosis via activating AMPK/Nrf2 signaling pathway in AML-12 hepatocytes and in mice livers. [Abstract]

2025 Sep 15:303:119045. PMID: 40945091
Ecotoxicol Environ Saf

Polystyrene nanoplastics-induced methuosis in brain microvascular endothelial cells: Rescue via ESCRT membrane repair system. [Abstract]

2025 Aug 8:303:118800. PMID: 40782538
Ecotoxicol Environ Saf

The PPARβ/CERK/C1P signaling pathway is a potential mechanism by which antimony exposure promotes prostate cancer cell proliferation. [Abstract]

2025 May 5:297:118268. PMID: 40327927
Ecotoxicol Environ Saf

Zinc oxide nanoparticles disrupt the mammary epithelial barrier via Z-DNA binding protein 1-triggered PANoptosis. [Abstract]

2024 Jul 24:283:116777. PMID: 39053182
Talanta

In vitro assessment of ferroptosis of cells exposed to cigarette smoke aerosol using a self-designed on-chip evaluation system based on gas-liquid dual-dimensional exposure. [Abstract]

2024 Jun 1:277:126352. PMID: 38838566
Ecotoxicol Environ Saf

Cadmium induces apoptosis of mouse spermatocytes through JNK activation and disruption of autophagic flux. [Abstract]

2023 Oct 15:265:115505. PMID: 37742578
Ecotoxicol Environ Saf

The rare-earth yttrium induces cell apoptosis and autophagy in the male reproductive system through ROS-Ca2+-CamkII/Ampk axis. [Abstract]

2023 Sep 15:263:115262. PMID: 37480693
Ecotoxicol Environ Saf

VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice. [Abstract]

2023 Jan 1:249:114359. PMID: 36508797
Ecotoxicol Environ Saf

PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells. [Abstract]

2022 Dec 15:248:114333. PMID: 36446170
Hum Reprod

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. [Abstract]

2021 Mar 18;36(4):951-964. PMID: 33378529
Cancer Cell Int

Cyclin dependent kinase 9 inhibitor induces transcription-replication conflicts and DNA damage accumulation in breast cancer. [Abstract]

2025 Jul 25;25(1):282. PMID: 40713627
Cancer Cell Int

Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells. [Abstract]

2024 Jul 17;24(1):249. PMID: 39020371
Cancer Cell Int

Identifying disulfidptosis subtypes in hepatocellular carcinoma through machine learning and preliminary exploration of its connection with immunotherapy. [Abstract]

2024 Jun 3;24(1):194. PMID: 38831301
Eur J Med Chem

Novel β-carboline derivatives show promise as dual-target inhibitors of DNA and TOP2A for the treatment of triple negative breast cancer. [Abstract]

2025 Nov 15:298:118041. PMID: 40779814
Food Biosci

2025 Mar.
Eur J Med Chem

Design, synthesis and biological evaluation of novel β-carbolines as antitumor agents via targeting autophagy in colorectal cancer. [Abstract]

2024 Dec 5:283:117145. PMID: 39653623
Eur J Med Chem

Ferroptosis-inducing compounds synergize with docetaxel to overcome chemoresistance in docetaxel-resistant non-small cell lung cancer cells. [Abstract]

2024 Jul 10:276:116670. PMID: 39018922
Front Immunol

African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation. [Abstract]

2024 May 10:15:1380220. PMID: 38799458
Front Immunol

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation. [Abstract]

2021 Mar 29;12:630380. PMID: 33854503
Front Immunol

Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis. [Abstract]

2021 Jul 7:12:688674. PMID: 34305921
Int J Mol Med

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer. [Abstract]

2026 Jan;57(1):4. PMID: 41133455
Int J Mol Med

Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO‑1‑mediated ferroptosis pathway. [Abstract]

2022 Jul;50(1):89. PMID: 35582998
Int J Mol Med

miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease. [Abstract]

2021 Apr;47(4):61. PMID: 33649797
Chin Med

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer. [Abstract]

2022 Sep 29;17(1):115. PMID: 36175965
J Invest Dermatol

The regulators of peroxisomal acyl-carnitine shuttle CROT and CRAT promote metastasis in melanoma. [Abstract]

2023 Feb;143(2):305-316.e5. PMID: 36058299
Biochem Pharmacol

Cabozantinib inhibits necroptosis by targeting MLKL oligomerization and alleviates psoriasis in vivo. [Abstract]

2026 Jun:248:117843. PMID: 41747872
Biochem Pharmacol

Structural and molecular characterization of a small-molecule TNF-α-TNFR1 inhibitor modulating cell death signaling. [Abstract]

2026 Apr:246:117727. PMID: 41571205
Biochem Pharmacol

Almonertinib inhibits liver cancer progression by triggering autophagy-dependent ferroptosis through inhibition of the PI3K/Akt1/mTOR pathway. [Abstract]

2025 Dec 9:245:117628. PMID: 41380804
Biochem Pharmacol

MEK inhibitor induces cardiac complications by preventing ZMYND8-mediated ubiquitination and proteasomal degradation of HMGB1. [Abstract]

2025 Dec 19:245:117660. PMID: 41423035
Biochem Pharmacol

Flubendazole inhibits cervical carcinoma by targeting DHODH to induce ferroptosis and mitophagy. [Abstract]

2025 Aug 28;242(Pt 1):117287. PMID: 40885318
Breast Cancer Res

THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer. [Abstract]

2025 Jul 6;27(1):124. PMID: 40619388
Biochem Pharmacol

Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia-reperfusion and bile salt toxicity. [Abstract]

2025 Jan 29:116788. PMID: 39890033
Biochem Pharmacol

Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]

2024 May:223:116194. PMID: 38583812
Biochem Pharmacol

Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis. [Abstract]

2023 Nov:217:115810. PMID: 37717690
Biochem Pharmacol

Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells. [Abstract]

2023 Sep:215:115636. PMID: 37290598
Biochem Pharmacol

STING activation in macrophages by vanillic acid exhibits antineoplastic potential. [Abstract]

2023 Jul:213:115618. PMID: 37211172
Biochem Pharmacol

Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism. [Abstract]

2022 Aug:202:115101. PMID: 35618001
Nephrol Dial Transplant

Bombesin receptor-activated protein exacerbates cisplatin-induced AKI by regulating the degradation of SIRT2. [Abstract]

2022 Nov 23;37(12):2366-2385. PMID: 35488871
Am J Chin Med

Sanguinarine Inhibits Gastric Cancer Progression by Targeting the NOS2/SOD1 Axis to Promote Ferroptosis. [Abstract]

2025;53(5):1545-1571. PMID: 40663435
Mol Cell Proteomics

Sulconazole induces PANoptosis by triggering oxidative stress and inhibiting glycolysis to increase radiosensitivity in esophageal cancer. [Abstract]

2023 Jun;22(6):100551. PMID: 37076047
Chem Biol Interact

Androgen receptor-NOX4-necroptosis axis drives male-biased susceptibility in aristolochic acid-induced acute kidney injury. [Abstract]

2026 Jun 1:432:112044. PMID: 41864472
World J Gastroenterol

Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance. [Abstract]

2026 Feb 28;32(8):113299. PMID: 41809875
Chem Biol Interact

Erianin reverses 5-FU resistance by targeting CALM1/CAMKK2 and activating autophagy in colorectal cancer. [Abstract]

2025 Sep 19:111750. PMID: 40976489
Chem Biol Interact

Cigarette smoke-induced glycerophospholipid DLPC promotes macrophage ferroptosis through the USP7/GPX4 regulatory axis in chronic obstructive pulmonary disease. [Abstract]

2025 Oct 22:420:111697. PMID: 40769290
Chem Biol Interact

A novel non-nad-based PARP1 inhibitor, Japoflavone B, triggered Caspase-3/GSDME-mediated pyroptosis through ROS/p38/p53 pathway in NSCLC. [Abstract]

2025 Oct 22:420:111693. PMID: 40754060
J Ethnopharmacol

Targeting GRB2-Akt-SREBP1 signaling axis by saponins from Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz to overcome cisplatin resistance in bladder cancer. [Abstract]

2025 Aug 27:354:120502. PMID: 40882789
Chem Biol Interact

Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma. [Abstract]

2025 Jun 18:111614. PMID: 40541645
Chem Biol Interact

Acetyl alkannin, a Shikonin monomer, inhibits the ATM/DDR pathway by targeting ATM and sensitizes cisplatin in solid tumors. [Abstract]

2025 May 17:111559. PMID: 40389196
Virulence

Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms. [Abstract]

2025 Dec;16(1):2496436. PMID: 40310883
Mar Drugs

Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer. [Abstract]

2025 Mar 12;23(3):123. PMID: 40137309
Chem Biol Interact

Lanostane triterpenoids from Ganoderma calidophilum exhibit potent anti-tumor activity by inhibiting PTP1B. [Abstract]

2024 Nov 1:403:111253. PMID: 39341486
Inflamm Res

Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury. [Abstract]

2024 Oct;73(10):1727-1745. PMID: 39112649
J Ethnopharmacol

Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway. [Abstract]

2024 Jan 10;318(Pt B):117025. PMID: 37567425
Chem Biol Interact

PI3K δ inhibitor PI-3065 induces apoptosis in hepatocellular carcinoma cells by targeting survivin. [Abstract]

2023 Feb 1:371:110343. PMID: 36623716
J Ethnopharmacol

Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro. [Abstract]

2021 Nov 15:280:114411. PMID: 34265380
Food Funct

Juglone, a novel activator of ferroptosis, induces cell death in endometrial carcinoma Ishikawa cells. [Abstract]

2021 Jun 8;12(11):4947-4959. PMID: 34100505
Chem Biol Interact

Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells. [Abstract]

2020 Nov 1;331:109279. PMID: 33035517
J Pathol

Fatty acid and cysteine metabolic interplay regulate ferroptosis and highlight xCT as a selenium-chrysin target in breast carcinoma. [Abstract]

2026 Feb 18. PMID: 41706708
Cells

The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens. [Abstract]

2024 Jul 3;13(13):1140. PMID: 38994991
Arab J Chem

2023 May 16, 104994.
Cells

Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF. [Abstract]

2022 Nov 12;11(22):3580. PMID: 36429010
Cells

TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. [Abstract]

2022 Sep 26;11(19):2992. PMID: 36230956
Cells

Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems. [Abstract]

2020 Jul 10;9(7):1661. PMID: 32664214
Commun Biol

NDRG2 upregulation induces astrocytic apoptosis via AKT inhibition and FoxO3a-Puma activation in depression. [Abstract]

2025 Nov 17;8(1):1585. PMID: 41249439
Commun Biol

Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration. [Abstract]

2025 Jul 29;8(1):1118. PMID: 40731132
Commun Biol

Biphasic protective effects of macrophage migration inhibitory factor in ischemia/reperfusion-induced acute kidney injury. [Abstract]

2025 Jul 28;8(1):1112. PMID: 40721484
Life Sci

Melatonin protects against particulate matter-induced ovarian dysfunction by activating the Nrf2 signaling pathway to alleviate ferroptosis. [Abstract]

2024 Nov 4:123200. PMID: 39505297
Commun Biol

USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1. [Abstract]

2024 Oct 8;7(1):1279. PMID: 39379617
Life Sci

Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage. [Abstract]

2023 Jun 1:322:121653. PMID: 37011875
Life Sci

5-((7-Chloro-6-fluoro-1h-indol-3-yl) methyl)-3-methylimidazolidine-2,4-dione as a RIP1 inhibitor protects LPS/D-galactosamine-induced liver failure. [Abstract]

2021 May 15:273:119304. PMID: 33662432
Biofactors

Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90/GPX4 Ubiquitination. [Abstract]

2025 Nov-Dec;51(6):e70063. PMID: 41292183
Inflammation

HNRNPC-Mediated m6A Epitranscriptomics Drives CD80-Dependent Tubular Dysfunction in Sepsis-Induced AKI. [Abstract]

2025 Nov 7. PMID: 41199093
Cancer Gene Ther

Demethoxycurcumin suppresses HK2-mediated glycolysis by targeting PTEN/Akt signaling. [Abstract]

2025 Oct 2. PMID: 41039015
Cancer Gene Ther

Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity. [Abstract]

2025 Jul;32(7):793-805. PMID: 40506561
Inflammation

MLKL-Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage. [Abstract]

2025 Apr 7. PMID: 40195182
Nutrients

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes. [Abstract]

2020 Sep 27;12(10):2954. PMID: 32992479
Int J Mol Sci

The Endogenous Metabolite TDCA Ameliorates LPS-Driven Liver Injury via Modulation of Caspase-11/GSDMD-Mediated Pyroptosis. [Abstract]

2026 Feb 28;27(5):2273. PMID: 41828497
Int J Mol Sci

MED12 Dictates Epithelial Ovarian Cancer Cell Ferroptosis Sensitivity via YAP-TEAD1 Signaling. [Abstract]

2026 Jan 20;27(2):1020. PMID: 41596664
Int J Mol Sci

Resveratrol-Supported Bioenergetics Leads to Higher Productivity and Accompanying Endoplasmic Reticulum Stress in a mAb-Producing CHO Cell Line. [Abstract]

2025 Nov 18;26(22):11146. PMID: 41303629
Biol Direct

MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1. [Abstract]

2025 Oct 1;20(1):100. PMID: 41035046
Int J Mol Sci

NEDD4L-Mediated Ubiquitination of GPX4 Exacerbates Doxorubicin-Induced Cardiotoxicity. [Abstract]

2025 Aug 23;26(17):8201. PMID: 40943126
PLoS Pathog

Sec10 suppresses antiviral innate immune response by facilitating STUB1-mediated STAT1 degradation. [Abstract]

2025 Sep 8;21(9):e1013472. PMID: 40920886
PLoS Pathog

Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction. [Abstract]

2025 Aug 19;21(8):e1013415. PMID: 40828869
PLoS Pathog

Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia. [Abstract]

2025 May 13;21(5):e1013167. PMID: 40359428
PLoS Pathog

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I. [Abstract]

2024 Oct 28;20(10):e1012670. PMID: 39466846
Int J Mol Sci

Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway. [Abstract]

2024 Sep 29;25(19):10509. PMID: 39408842
Int J Mol Sci

A Genetically Encoded Dark-to-Bright Biosensor for Visualisation of Granzyme-Mediated Cytotoxicity. [Abstract]

2023 Sep 2;24(17):13589. PMID: 37686395
PLoS Pathog

Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication. [Abstract]

2023 Jul 27;19(7):e1011550. PMID: 37498975
Int J Mol Sci

Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin. [Abstract]

2023 Jul 20;24(14):11692. PMID: 37511451
Int J Mol Sci

Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. [Abstract]

2023 Apr 17;24(8):7402. PMID: 37108564
Int J Oncol

Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect. [Abstract]

2023 Mar;62(3):44. PMID: 36825592
Int J Mol Sci

Induction of Apoptosis by Matrine Derivative ZS17 in Human Hepatocellular Carcinoma BEL-7402 and HepG2 Cells through ROS-JNK-P53 Signalling Pathway Activation. [Abstract]

2022 Dec 15;23(24):15991. PMID: 36555631
Int J Mol Sci

The Possible Connection of Two Dual Function Processes: The Relationship of Ferroptosis and the JNK Pathway. [Abstract]

2022 Sep 20;23(19):11004. PMID: 36232313
Int J Oncol

Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells in vitro and in vivo. [Abstract]

2022 Nov;61(5):131. PMID: 36111510
Pharm Biol

Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation. [Abstract]

2026 Dec;64(1):514-535. PMID: 41877645
Biomolecules

Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis. [Abstract]

2026 Feb 25;16(3):345. PMID: 41897283
Cell Oncol (Dordr)

A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression. [Abstract]

2025 Oct 6. PMID: 41051594
Front Pharmacol

Pomolic acid induces ferroptosis-mediated cell death in non-small cell lung cancer. [Abstract]

2025 Jun 4:16:1567942. PMID: 40535769
Front Pharmacol

β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction. [Abstract]

2024 Oct 17:15:1469180. PMID: 39484165
Pharmaceuticals (Basel)

The Proteasome Inhibitor Marizomib Evokes Endoplasmic Reticulum Stress and Promotes Apoptosis in Human Glioblastoma Cells. [Abstract]

2024 Aug 20;17(8):1089. PMID: 39204194
Front Cell Infect Microbiol

Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis. [Abstract]

2022 Feb 4;12:825824. PMID: 35186798
Front Pharmacol

Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT. [Abstract]

2021 May 10:12:670224. PMID: 34040532
Front Pharmacol

Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer. [Abstract]

2021 Apr 15:12:621181. PMID: 33935713
Front Pharmacol

Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells. [Abstract]

2020 Dec 10:11:534171. PMID: 33362534
Front Pharmacol

Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis. [Abstract]

2020 Feb 21;11:123. PMID: 32153415
Int Immunopharmacol

TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer. [Abstract]

2025 Nov 8;168(Pt 1):115798. PMID: 41207103
Eur J Pharmacol

Cinobufagin suppresses T-ALL via USP7-Mediated inhibition of NOTCH1/PI3K signaling pathways. [Abstract]

2025 Dec 5:1008:178373. PMID: 41241328
Bioorg Chem

Usenamine A, an RGS2 inhibitor, exerts anti-NSCLC activity and enhances cytotoxicity of gemcitabine by inducing ER stress and Notch1-mediated autophagy. [Abstract]

2025 Sep 17:165:109010. PMID: 40974657
Int Immunopharmacol

Calreticulin-driven immunogenic cell death promotes osteoclast differentiation and osteoarthritis progression via the LRP1/Rac1 signaling. [Abstract]

2025 Jul 25:163:115277. PMID: 40714468
Int Immunopharmacol

Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. [Abstract]

2025 May 12:158:114827. PMID: 40359890
J Mol Struct

2025 Aug 25.
Eur J Pharmacol

Mechanism of berbamine-mediated DNA damage in synovial fibroblasts to alleviate rheumatoid arthritis. [Abstract]

2025 Apr 2:177597. PMID: 40185320
Bioorg Chem

2β-methoxy-2-deethoxyphantomolin synergistically enhances epirubicin effect against triple-negative breast cancer via targeted inhibition of AKT and HR pathways. [Abstract]

2025 Apr 8:160:108453. PMID: 40253761
Int Immunopharmacol

The emerging role of IL-22 as a potential radiosensitivity biomarker for radiation-induced intestinal injury. [Abstract]

2025 Apr 7:155:114573. PMID: 40199137
Int Immunopharmacol

Prexasertib exerts a synergistic effect on the antitumor activity of Lenvatinib through ALOX15-mediated ferroptosis in hepatocellular carcinoma. [Abstract]

2025 Mar 26:150:114278. PMID: 39954659
Int Immunopharmacol

Hedyotis diffusa injection modulates the ferroptosis in bladder cancer via CAV1/JUN/VEGFA. [Abstract]

2025 Jan 6:147:113925. PMID: 39765005
Int Immunopharmacol

CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1. [Abstract]

2024 Nov 13;143(Pt 3):113617. PMID: 39541845
Int Immunopharmacol

Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα. [Abstract]

2024 Dec 9:145:113781. PMID: 39657538
Int Immunopharmacol

Disulfiram mediated anti-tumour effect in pituitary neuroendocrine tumours by inducing cuproptosis. [Abstract]

2024 Jun 15:134:112159. PMID: 38692018
mBio

Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner. [Abstract]

2024 Mar 13;15(3):e0343323. PMID: 38289089
Mol Ther Methods Clin Dev

All-in-one IQ toggle switches with high versatilities for fine-tuning of transgene expression in mammalian cells and tissues. [Abstract]

2024 Feb 2;32(1):101202. PMID: 38374964
Eur J Pharmacol

Fisetin suppresses ferroptosis through Nrf2 and attenuates intervertebral disc degeneration in rats. [Abstract]

2024 Feb 5:964:176298. PMID: 38145645
Int Immunopharmacol

4-Octyl itaconate inhibits inflammation to attenuate psoriasis as an agonist of oxeiptosis. [Abstract]

2023 Sep 21;124(Pt B):110915. PMID: 37741130
mBio

Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C. [Abstract]

2022 Oct 26;13(5):e0143422. PMID: 36106732
mBio

MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway. [Abstract]

2022 Feb 22;13(1):e0233021. PMID: 35076286
ACS Appl Bio Mater

Tetrahedral DNA Nanostructures Inhibit Ferroptosis and Apoptosis in Cisplatin-induced Renal Injury. [Abstract]

2021 Jun 21;4(6):5026-5032. PMID: 35007051
Neuropharmacology

Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]

2026 Jul 1:292:110950. PMID: 41887568
Molecules

RNA-Binding Motif Protein 22 Induces Apoptosis via c-Myc Pathway in Colon Cancer Cells. [Abstract]

2025 Mar 9;30(6):1227. PMID: 40142004
Molecules

Research for a Common Thread: Insights into the Mechanisms of Six Potential Anticancer Agents. [Abstract]

2025 Feb 24;30(5):1031. PMID: 40076255
Toxicology

Acidosis induces autophagic cell death through ASIC1-mediated Akt/mTOR signaling in HT22 neurons. [Abstract]

2025 Jan 3:154045. PMID: 39756784
Toxicology

Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways. [Abstract]

2024 Aug 6:153906. PMID: 39117261
Molecules

Antiproliferation Activity and Mechanism of c9, t11, c15-CLNA and t9, t11, c15-CLNA from Lactobacillus plantarum ZS2058 on Colon Cancer Cells. [Abstract]

2020 Mar 9;25(5):1225. PMID: 32182796
Cell Rep Methods

Generation of dual-attribute iTNK cells from hPSCs for cancer immunotherapy. [Abstract]

2024 Aug 27:100843. PMID: 39216483
Mol Pharm

Saponin and Ribosome-Inactivating Protein Synergistically Trigger Lysosome-Dependent Apoptosis by Inhibiting Lysophagy: Potential to Become a New Antitumor Strategy. [Abstract]

2024 May 9. PMID: 38722865
Mol Oncol

Dinaciclib synergizes with BH3 mimetics targeting BCL-2 and BCL-XL in multiple myeloma cell lines partially-dependent on MCL-1 and in plasma cells from patients. [Abstract]

2023 Dec;17(12):2507-2525. PMID: 37704591
Cancers (Basel)

Triptolide Triggers Protective Autophagy via ROS Induction in NSCLC: Therapeutic Synergy with Autophagy Inhibition. [Abstract]

2026 Mar 11;18(6):902. PMID: 41899507
Cancers (Basel)

Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism. [Abstract]

2025 Dec 27;18(1):92. PMID: 41514605
J Dairy Sci

Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis. [Abstract]

2025 Aug;108(8):8844-8858. PMID: 40513868
Clin Epigenetics

Venetoclax confers synthetic lethality to chidamide in preclinical models with transformed follicular lymphoma. [Abstract]

2025 May 4;17(1):74. PMID: 40320542
Cancers (Basel)

PT-112 Induces Mitochondrial Stress and Immunogenic Cell Death, Targeting Tumor Cells with Mitochondrial Deficiencies. [Abstract]

2022 Aug 9;14(16):3851. PMID: 36010843
Cancer Sci

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1. [Abstract]

2025 Aug;116(8):2256-2269. PMID: 40485050
Cancer Sci

PSMD14/E2F1 Axis-Mediated CENPF Promotes the Metastasis of Triple-Negative Breast Cancer Through Inhibiting Ferroptosis. [Abstract]

2025 Aug;116(8):2281-2295. PMID: 40365861
Cancer Sci

Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death. [Abstract]

2025 Mar 26. PMID: 40138733
Mol Neurobiol

DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau. [Abstract]

2024 May;61(5):2978-2995. PMID: 37955806
Mol Neurobiol

Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3. [Abstract]

2022 Nov;59(11):6934-6955. PMID: 36053436
Front Cell Dev Biol

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor. [Abstract]

2020 Jan 22;7:393. PMID: 32039207
FASEB J

Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis. [Abstract]

2026 Mar 31;40(6):e71636. PMID: 41842655
Poult Sci

Quercetin attenuates deoxynivalenol-induced muscle developmental disorders in broilers by modulating the PI3K/Akt/mTOR pathway and reducing apoptosis. [Abstract]

2026 Mar 5;105(6):106740. PMID: 41850073
FEBS J

The sulfonamide anticancer agent indisulam enhances the chemosensitivity of gastric cancer cells by targeting FKBP8. [Abstract]

2026 Mar 20. PMID: 41860182
FASEB J

EM2, a Novel Elephantopus mollis H.B.K. Monomer, Enhances Radiosensitivity in Cervical Cancer Through Dual Inhibition of AKT and Autophagy. [Abstract]

2026 Jan 31;40(2):e71454. PMID: 41527777
FEBS J

Pentraxin-related protein PTX3 alleviates blast-induced acute lung injury by promoting efferocytosis to eliminate ferroptotic alveolar epithelial cells in vitro. [Abstract]

2025 Dec 3. PMID: 41340229
Biochim Biophys Acta Mol Basis Dis

Mechanistic and target study of anthraquinone modifier KA-4c triggering endoplasmic reticulum stress to inhibit triple-negative breast cancer cells. [Abstract]

2025 Aug 18;1871(8):168020. PMID: 40835211
J Cell Mol Med

Identification of FADS2 as a Contributor of Ferroptosis Escape in Bladder Cancer. [Abstract]

2025 Jul;29(14):e70710. PMID: 40682485
J Cell Mol Med

Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes. [Abstract]

2025 Jul;29(13):e70592. PMID: 40576283
Biochim Biophys Acta Mol Basis Dis

Study on the synthesis, characterization, and antitumor mechanism investigation of QZQ-01115 via targeting sphingosine kinase 2. [Abstract]

2025 Apr 9:167829. PMID: 40216369
Biochim Biophys Acta Mol Basis Dis

Oncogenic HNF4α inhibits ferroptotic cell death through activating SLC7A11 by recruiting p300/CBP in breast cancer. [Abstract]

2025 Aug;1871(6):167884. PMID: 40320185
J Clin Transl Hepatol

GPX4 Promoter Hypermethylation Induced by Ischemia/Reperfusion Injury Regulates Hepatocytic Ferroptosis. [Abstract]

2024 Nov 28;12(11):917-929. PMID: 39544244
J Cell Mol Med

Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway. [Abstract]

2024 Apr;28(8):e18335. PMID: 38652216
FASEB J

HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma. [Abstract]

2022 Jun;36(6):e22359. PMID: 35621121
FASEB J

HTBPI, an active phenanthroindolizidine alkaloid, inhibits liver tumorigenesis by targeting Akt. [Abstract]

2020 Sep;34(9):12255-12268. PMID: 33411355
J Cell Mol Med

Hinokiflavone induces apoptosis via activating mitochondrial ROS/JNK/caspase pathway and inhibiting NF-κB activity in hepatocellular carcinoma. [Abstract]

2020 Jul;24(14):8151-8165. PMID: 32519392
J Inflamm Res

Cell Death-Related Genesets Activity Improved Clinical Concordance and Intrinsically Associated with Alterations in Ulcerative Colitis: Mucosal Healing at Molecular Depth. [Abstract]

2025 Jul 19:18:9587-9608. PMID: 40708727
iScience

NRF2 regulates lipid droplet dynamics to prevent lipotoxicity. [Abstract]

2025 Jun 18;28(7):112925. PMID: 40678507
Transl Oncol

Triptonide stabilizes BIM to enhance oxaliplatin-induced ferroptosis and apoptosis in colorectal cancer. [Abstract]

2025 Oct:60:102491. PMID: 40773827
Transl Oncol

Exploring the role of disulfidptosis-related signatures in immune microenvironment, prognosis and therapeutic strategies of cervical cancer. [Abstract]

2024 Jun:44:101938. PMID: 38492499
Comput Struct Biotechnol J

Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. [Abstract]

2022 Jun 14:20:3019-3029. PMID: 35782728
Nanoscale Res Lett

Fe(II) and Tannic Acid-Cloaked MOF as Carrier of Artemisinin for Supply of Ferrous Ions to Enhance Treatment of Triple-Negative Breast Cancer. [Abstract]

2021 Feb 23;16(1):37. PMID: 33620584
Hum Gene Ther

HIV Tat- conjugated Histone H3 peptides induce tumor cell death via cellular stress responses. [Abstract]

2023 Jan;34(1-2):42-55. PMID: 36373826
Virol Sin

FoxJ1 inhibits African swine fever virus replication and viral S273R protein decreases the expression of FoxJ1 to impair its antiviral effect. [Abstract]

2022 Jun;37(3):445-454. PMID: 35513267
J Cell Physiol

MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells. [Abstract]

2020 Jul;235(7-8):5637-5648. PMID: 31960438
Sci Rep

APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer. [Abstract]

2026 Mar 15;16(1):13595. PMID: 41840064
Aquaculture

2025 Sep 6;612:743164.
Oncol Rep

REV1‑targeting inhibitor JH‑RE‑06 induces ferroptosis via NCOA4‑mediated ferritinophagy in colorectal cancer cells. [Abstract]

2025 Dec;54(6):159. PMID: 40999956
Oncol Rep

HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma. [Abstract]

2025 Aug;54(2):94. PMID: 40539448
ACS Chem Neurosci

Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach. [Abstract]

2025 Apr 16;16(8):1550-1564. PMID: 40156525
Sci Rep

Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells. [Abstract]

2024 Dec 4;14(1):30163. PMID: 39627455
Fish Shellfish Immunol

Myo-inositol: A potential game-changer in preventing gill cell death and alleviating "gill rot" in grass carp (Ctenopharyngodon idellus). [Abstract]

2024 Aug 21:109850. PMID: 39179187
Sci Rep

Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin. [Abstract]

2024 Jun 21;14(1):14307. PMID: 38906931
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Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage. [Abstract]

2024 May 30;14(1):12427. PMID: 38816543
Fish Shellfish Immunol

Nano-selenium protects grass carp hepatocytes against 4-tert-butylphenol-induced mitochondrial apoptosis and necroptosis via suppressing ROS-PARP1 axis. [Abstract]

2023 Apr:135:108682. PMID: 36924910
J Biol Chem

Glucose-6-phosphate dehydrogenase exerts anti-stress effects independently of its enzymatic activity. [Abstract]

2022 Dec;298(12):102587. PMID: 36243112
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Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma. [Abstract]

2021 May 19;11(1):10609. PMID: 34011952
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CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn's disease. [Abstract]

2021 Jan 12;11(1):565. PMID: 33436852
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Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway. [Abstract]

2020 Nov 29;12(23):24318-24332. PMID: 33260158
Aging

Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF-κB and mTOR pathways in ovarian cancer. [Abstract]

2020 Nov 25;12(24):25730-25743. PMID: 33234722
J Virol

DIDS modulates VDAC1 oligomerization to suppress intrinsic apoptosis and attenuates in vitro and in vivo RSV infection. [Abstract]

2026 Mar 24;100(3):e0220025. PMID: 41670372
J Virol

FMDV 3A cooperates with PDCD10 to promote FMDV replication by inhibiting VISA-mediated innate immunity. [Abstract]

2025 Nov 26:e0065725. PMID: 41296880
ACS Infect Dis

The Outer Membrane Protein Tp92 of Treponema pallidum Induces BeWo Cells Apoptosis and Oxidative Stress via the Nrf2/keap1 Pathway. [Abstract]

2025 Aug 19. PMID: 40830074
J Virol

Cullin 3-mediated ubiquitination restricts enterovirus D68 replication and is counteracted by viral protease 3C. [Abstract]

2025 May 21:e0035425. PMID: 40396757
J Virol

Heat shock protein A1 inhibits the replication of foot-and-mouth disease virus by degrading viral RNA polymerase 3D through chaperone-mediated autophagy. [Abstract]

2025 Mar 31:e0016825. PMID: 40162788
J Virol

Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy. [Abstract]

2024 Dec 6:e0144924. PMID: 39641621
J Virol

Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication. [Abstract]

2024 Oct 22;98(10):e0104824. PMID: 39212384
Chem Res Toxicol

The Selective SIRT3 Inhibitor 3-TYP Represses Primary Myeloma Growth by Reducing c-Myc Stability. [Abstract]

2024 Jun 17;37(6):1062-1069. PMID: 38815162
J Virol

SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis. [Abstract]

2024 Feb 20;98(2):e0190923. PMID: 38289118
Microbiol Spectr

CSFV restricts necroptosis to sustain infection by inducing autophagy/mitophagy-targeted degradation of RIPK3. [Abstract]

2024 Jan 11;12(1):e0275823. PMID: 38100396
Clin Immunol

The role of B-cell ferroptosis in the pathogenesis of systemic lupus erythematosus. [Abstract]

2023 Nov:256:109778. PMID: 37730009
J Virol

Foot-and-mouth disease virus downregulates vacuolar protein sorting 28 to promote viral replication. [Abstract]

2023 Aug 31;97(8):e0018123. PMID: 37565750
Cell Signal

Estradiol alleviates disease phenotypes caused by m.3635G > a mutations by activating mitochondrial biogenesis and PINK1-Parkin mediated mitophagy in iPSC-derived retinal pigment epithelium cells. [Abstract]

2025 Sep 8:136:112121. PMID: 40930474
Cell Signal

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62. [Abstract]

2025 Nov:135:112024. PMID: 40721064
Cell Signal

CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway. [Abstract]

2025 Nov:135:111998. PMID: 40664345
Cell Signal

Natural exosome-like nanovesicles from Salvia chinensis Benth induce ferroptosis to suppress hepatocellular carcinoma progression via AMPK/Nrf2/xCT axis. [Abstract]

2025 Jun 6:111928. PMID: 40484104
Cell Signal

PRAP1 regulates colorectal cancer cell proliferation and ferroptosis through the Nrf2 signaling pathway. [Abstract]

2025 May 13:111863. PMID: 40373840
Int Dent J

New Insights Into the Correlation Between Necroptotic Activation and Neutrophil Infiltration in Pulpitis. [Abstract]

2025 Mar 25;75(3):1649-1661. PMID: 40138999
Mol Cell Biochem

STAT1 increases the sensitivity of lung adenocarcinoma to carbon ion irradiation via HO-1-mediated ferroptosis. [Abstract]

2025 Jul;480(7):4265-4281. PMID: 40087208
Cell Signal

HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism. [Abstract]

2025 Jan 3:111583. PMID: 39756501
Biochim Biophys Acta Mol Cell Res

Enhanced radiotherapy susceptibility in NSCLC through palbociclib-mediated PP5 inhibition. [Abstract]

2024 Nov 29:119884. PMID: 39617046
Biochim Biophys Acta Mol Cell Res

Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway. [Abstract]

2024 Jan;1871(1):119603. PMID: 37805058
Mol Cell Biochem

A novel 2-iminobenzimidazole compound, XYA1353, displays in vitro and in vivo anti-myeloma activity via targeting NF-κB signaling. [Abstract]

2024 Apr;479(4):843-857. PMID: 37204666
Exp Mol Pathol

RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways. [Abstract]

2021 Feb;118:104571. PMID: 33166495
Mol Cell Biochem

OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma. [Abstract]

2020 Sep;472(1-2):219-230. PMID: 32671513
Cytokine

PI3K mediates tumor necrosis factor induced-necroptosis through initiating RIP1-RIP3-MLKL signaling pathway activation. [Abstract]

2020 May;129:155046. PMID: 32114297
Heliyon

Huaier inhibits autophagy and promotes apoptosis in T-cell acute lymphoblastic leukemia by down-regulating SIRT1. [Abstract]

2024 Aug 31;10(17):e37313. PMID: 39286166
Heliyon

Induction of ferroptosis by brucine suppresses gastric cancer progression through the p53-mediated SLCA711/ALOX12 axis. [Abstract]

2024 Jun 26;10(13):e33674. PMID: 39050447
Heliyon

Plumbagin induces ferroptosis in colon cancer cells by regulating p53-related SLC7A11 expression. [Abstract]

2024 Mar 21;10(7):e28364. PMID: 38596137
Heliyon

Ursolic acid induces apoptosis and pyroptosis in Reh cells by upregulating of the JNK signalling pathway based on network pharmacology and experimental validation. [Abstract]

2023 Dec 1;9(12):e23079. PMID: 38144346
J Nat Prod

Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma. [Abstract]

2023 Apr 28;86(4):966-978. PMID: 37043698
Heliyon

3-Deoxysappanchalcone isolated from Caesalpinia sinensis shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway. [Abstract]

2022 Oct 12;8(10):e11013. PMID: 36276736
J Cell Sci

AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. [Abstract]

2022 Jan 1;135(1):jcs258910. PMID: 34859815
Heliyon

The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis. [Abstract]

2021 Nov 15;7(11):e08399. PMID: 34841108
Exp Cell Res

Baicalein protects human keratinocytes against PM2.5-induced apoptosis by suppressing oxidative stress, endoplasmic reticulum stress, and ERK/JNK signaling. [Abstract]

2026 Jul 1;460(1):115063. PMID: 42119881
Mol Med Rep

Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway. [Abstract]

2026 Jan;33(1):24. PMID: 41201015
Vet Res

Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway. [Abstract]

2025 Sep 25;56(1):182. PMID: 40999490
Exp Cell Res

PERK suppression induces susceptibility to ferroptosis in lupus nephritis. [Abstract]

2025 Aug 25;452(1):114725. PMID: 40865630
Viruses

DNAJ Homolog Subfamily C Member 11 Stabilizes SARS-CoV-2 NSP3 to Promote Double-Membrane Vesicle Formation. [Abstract]

2025 Jul 22;17(8):1025. PMID: 40872740
Vet Res

African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity. [Abstract]

2025 Jul 5;56(1):137. PMID: 40618140
Med Oncol

Novel PI3Kδ inhibitor exerts antitumor activity in Burkitt lymphoma by inducing ROS-dependent apoptosis. [Abstract]

2025 Jun 21;42(7):277. PMID: 40544227
Food Chem Toxicol

Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation. [Abstract]

2025 Jun 4:203:115592. PMID: 40480416
Mol Hum Reprod

Eutopic macrophages facilitate endometriosis progression via ferroptosis-mediated release of S100A9. [Abstract]

2025 Jun 10:gaaf027. PMID: 40493892
Exp Cell Res

Palmitic acid induces β-cell ferroptosis by activating ceramide signaling pathway. [Abstract]

2024 Jun 19:114134. PMID: 38901790
Mol Med Rep

Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress. [Abstract]

2024 May;29(5):71. PMID: 38456480
Exp Cell Res

Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis inhibitor against septic acute kidney injury. [Abstract]

2023 Dec 1;433(1):113804. PMID: 37806378
Med Oncol

Zoledronic acid induces ferroptosis by upregulating POR in osteosarcoma. [Abstract]

2023 Apr 10;40(5):141. PMID: 37036615
Mol Med Rep

Activating autophagy and ferroptosis of 3‑Chloropropane‑1,2‑diol induces injury of human umbilical vein endothelial cells via AMPK/mTOR/ULK1. [Abstract]

2023 Mar;27(3):76. PMID: 36799162
Med Oncol

Andrographolide elevates tumor necrosis factor-related apoptosis-inducing ligand lethality through reactive oxygen species accumulation and gasdermin E cleavage in breast cancer cells. [Abstract]

2022 Nov 9;40(1):11. PMID: 36352155
Exp Cell Res

Targeting PI3K/AKT/mTOR pathway to enhance the anti-leukemia efficacy of venetoclax. [Abstract]

2022 May 11;417(2):113192. PMID: 35568072
Exp Cell Res

Indole-3-carbinol ameliorates necroptosis and inflammation of intestinal epithelial cells in mice with ulcerative colitis by activating aryl hydrocarbon receptor. [Abstract]

2021 Jul 15;404(2):112638. PMID: 34015312
Viruses

Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites. [Abstract]

2019 Dec 30;12(1):43. PMID: 31905881
Int J Parasitol Drugs Drug Resist

Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro. [Abstract]

2025 Dec:29:100624. PMID: 41187614
Toxicol Appl Pharmacol

Chrysin enhances sunitinib sensitivity in renal cell carcinoma by inducing ferroptosis via targeting PI3K/Akt/GPX4 pathway. [Abstract]

2025 Aug 21:117531. PMID: 40848919
Eur J Med Res

Tetrathiomolybdate alleviates bleomycin-induced pulmonary fibrosis by reducing copper concentration and suppressing EMT. [Abstract]

2025 May 19;30(1):394. PMID: 40390111
Eur J Med Res

RNA-binding protein DAZAP1 accelerates the advancement of pancreatic cancer by inhibiting ferroptosis. [Abstract]

2025 Jan 4;30(1):3. PMID: 39754243
Biologics

STAT5B Suppresses Ferroptosis by Promoting DCAF13 Transcription to Regulate p53/xCT Pathway to Promote Mantle Cell Lymphoma Progression. [Abstract]

2024 Jul 4:18:181-193. PMID: 38979130
J Hepatocell Carcinoma

miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway. [Abstract]

2023 Dec 6:10:2173-2185. PMID: 38084209
Acta Biochim Biophys Sin (Shanghai)

Glutamine deprivation induces ferroptosis in pancreatic cancer cells. [Abstract]

2023 Mar 20;55(8):1288-1300. PMID: 36942991
BMC Cancer

CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma. [Abstract]

2022 Nov 17;22(1):1184. PMID: 36397015
Toxicol Appl Pharmacol

Albendazole-induced autophagy blockade contributes to elevated apoptosis in cholangiocarcinoma cells through AMPK/mTOR activation. [Abstract]

2022 Nov 1:454:116214. PMID: 36055539
Toxicol Appl Pharmacol

A novel halogenated adenosine analog 5'-BrDA displays potent toxicity against colon cancer cells in vivo and in vitro. [Abstract]

2022 Feb 1:436:115857. PMID: 34979143
Front Physiol

Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine. [Abstract]

2019 Jan 15;9:1922. PMID: 30697165
Biochim Biophys Acta Mol Cell Biol Lipids

Integrated proteomic and metabolomic analysis reveals lipid metabolic dysregulation and ferroptosis as potential drivers of placental dysfunction in intrahepatic cholestasis of pregnancy. [Abstract]

2025 Oct 3;1871(1):159692. PMID: 41047095
Front Oncol

p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation. [Abstract]

2025 Jun 24:15:1584811. PMID: 40630211
Chem Biol Drug Des

Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation. [Abstract]

2024 Aug;104(2):e14560. PMID: 39175059
Stem Cells Int

Shikonin Induces Glioma Necroptosis, Stemness Decline, and Impedes (Immuno)Proteasome Activity. [Abstract]

2024 Mar 14:2024:1348269. PMID: 39619148
Front Oncol

The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51. [Abstract]

2021 Mar 25:11:646256. PMID: 33842359
Pathol Res Pract

FBXW7 promotes osteoarthritis injury by regulating SLC7A11 ubiquitination degradation and chondrocyte ferroptosis. [Abstract]

2026 Jan:277:156297. PMID: 41274067
Mol Carcinog

KIF4A Inhibits Ferroptosis in Glioblastoma via the CHMP4B/GPX4 Axis and Promotes Temozolomide Resistance. [Abstract]

2025 Jul 24. PMID: 40705827
J Inorg Biochem

Iridium(III) complexes as type I photosensitizers for hypoxic two-photon photodynamic therapy. [Abstract]

2025 Nov:272:113006. PMID: 40682924
J Cancer

Resveratrol Induces Oxidative Stress and Downregulates GPX4 and xCT to Activate the Ferroptosis Pathway for Anti-Bladder Cancer Organoids. [Abstract]

2025 Jun 9;16(8):2613-2625. PMID: 40535803
J Cancer

Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells. [Abstract]

2024 Mar 4;15(8):2380-2390. PMID: 38495480
J Cancer

Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma. [Abstract]

2023 Aug 6;14(13):2481-2490. PMID: 37670974
Mol Carcinog

PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. [Abstract]

2023 Aug;62(8):1119-1135. PMID: 37144835
J Cancer

PERK/ATF3-Reduced ER Stress on high potassium environment in the suppression of tumor ferroptosis. [Abstract]

2023 May 15;14(8):1336-1349. PMID: 37283787
Mol Carcinog

Guangsangon E triggers mitochondria dysfunction and mitophagy in triple-negative breast cancer and leads to non-apoptotic cell death. [Abstract]

2022 Dec;61(12):1128-1142. PMID: 36121321
J Cancer

POU4F3 Acts as a Tumor Suppressor in Lung Adenocarcinoma via the Endoplasmic Reticulum Stress Signaling Pathway. [Abstract]

2022 Jan 1;13(2):554-564. PMID: 35069902
Hum Exp Toxicol

EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells. [Abstract]

2021 Dec;40(12_suppl):S49-S62. PMID: 34219533
Environ Toxicol

Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes. [Abstract]

2021 Apr;36(4):520-529. PMID: 33166055
Environ Toxicol

Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis. [Abstract]

2021 Feb;36(2):257-266. PMID: 32951314
Cell Biol Int

Concurrent Ferroptosis and Apoptosis in Resveratrol-Treated Glioblastoma Cells: Relevance With NRF2 Downregulation and Oxidative Stress. [Abstract]

2026 Mar;50(3):e70153. PMID: 41841014
J Pharm Biomed Anal

Identification of Novel Anti- non-small cell lung cancer (NSCLC) Peptide in toad Skin（Chan Pi） Extract through Integrated Peptidomics and in silico Screening. [Abstract]

2026 Aug 1:275:117456. PMID: 41856053
Front Biosci (Landmark Ed)

SB431542, a Selective Inhibitor of the TGF-β Type I Receptor, Enhances Doxorubicin Antitumor Activity via p63 Activation in Mutant p53 Breast Cancer Cells. [Abstract]

2025 Dec 18;30(12):45389. PMID: 41504053
Front Biosci (Landmark Ed)

Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells. [Abstract]

2025 Nov 27;30(11):46410. PMID: 41351403
Cardiovasc Drugs Ther

ALKBH5 Regulates Inflammation and Pyroptosis of Coronary Heart Disease by Targeting SPEN in a YTHDF1-Mediated Manner. [Abstract]

2025 Jul 26. PMID: 40715613
Cancer Med

Dihydroartemisinin Sensitizes Lung Cancer Cells to Cisplatin Treatment by Upregulating ZIP14 Expression and Inducing Ferroptosis. [Abstract]

2024 Oct;13(19):e70271. PMID: 39394878
Glycoconj J

RACK1 inhibits ferroptosis of cervical cancer by enhancing SLC7A11 core-fucosylation. [Abstract]

2024 Oct;41(4-5):229-240. PMID: 39356381
Front Biosci (Landmark Ed)

A Novel Photosensitizer Based 450-nm Blue Laser-Mediated Photodynamic Therapy Induces Apoptosis in Colorectal Cancer - in Vitro and in Vivo Study. [Abstract]

2024 May 21;29(5):199. PMID: 38812322
Front Biosci (Landmark Ed)

Maintenance of the Expression of c-FLIPL by Hsp70 to Resist Licochalcone A-Induced Anti-Colorectal Cancer Effect through ERK-Mediated Autophagy Induction. [Abstract]

2023 Dec 1;28(12):325. PMID: 38179732
Naunyn Schmiedebergs Arch Pharmacol

Integrating network pharmacology and experimental models to examine the mechanisms of corosolic acid in preventing hepatocellular carcinoma progression through activation PERK-eIF2a-ATF4 signaling. [Abstract]

2023 Dec;396(12):3671-3682. PMID: 37294427
Kaohsiung J Med Sci

Dihydroartemisinin enhances gefitinib cytotoxicity against lung adenocarcinoma cells by inducing ROS-dependent apoptosis and ferroptosis. [Abstract]

2023 Jul;39(7):699-709. PMID: 37057810
Curr Issues Mol Biol

Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway. [Abstract]

2026 Jan 27;48(2):138. PMID: 41751402
Curr Res Toxicol

Scoparone induces mitophagy and apoptosis via ROS accumulation in pancreatic cancer cells. [Abstract]

2026 Jan 17:10:100281. PMID: 41630986
Biochimie

Evaluating the cytotoxicity mechanism of the cell-penetrating peptide TP10 on Jurkat cells. [Abstract]

2024 Jun:221:182-192. PMID: 37922978
Arch Biochem Biophys

Tanshinone IIA inhibits endometrial carcinoma growth through the MAPK/ERK/TRIB3 pathway. [Abstract]

2023 Jul 15:743:109655. PMID: 37285895
Arch Biochem Biophys

PHKG2 regulates RSL3-induced ferroptosis in Helicobacter pylori related gastric cancer. [Abstract]

2023 May 15:740:109560. PMID: 36948350
Mol Immunol

Synergism of TNF-α and IFN-β triggers human airway epithelial cells death by apoptosis and pyroptosis. [Abstract]

2023 Jan:153:160-169. PMID: 36508750
Curr Issues Mol Biol

Baicalein Relieves Ferroptosis-Mediated Phagocytosis Inhibition of Macrophages in Ovarian Endometriosis. [Abstract]

2022 Dec 7;44(12):6189-6204. PMID: 36547083
Mol Immunol

RIPK1 regulates cell function and death mediated by UVB radiation and TNF-α. [Abstract]

2021 Jul:135:304-311. PMID: 33964631
Anticancer Agents Med Chem

Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells. [Abstract]

2020;20(6):687-699. PMID: 32053082
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Rosmarinic acid induces ferroptosis in colon cancer: insights from AKR1C3/PTGS2 pathway and mitochondrial dysfunction. [Abstract]

2025 Nov;15(11):374. PMID: 41064160
Discov Oncol

Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway. [Abstract]

2025 Jun 2;16(1):983. PMID: 40451984
Discov Oncol

Toxicarioside H induces ferroptosis in triple-negative breast cancer cells through Nrf2/HO-1 pathway. [Abstract]

2025 May 15;16(1):772. PMID: 40372576
Free Radic Res

Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress. [Abstract]

2024 Nov;58(11):686-701. PMID: 39422606
Oral Dis

Indoxyl sulfate exacerbates alveolar bone loss in chronic kidney disease through ferroptosis. [Abstract]

2025 Jan;31(1):264-277. PMID: 38934473
Am J Cancer Res

LINC02362/hsa-miR-18a-5p/FDX1 axis suppresses proliferation and drives cuproptosis and oxaliplatin sensitivity of hepatocellular carcinoma. [Abstract]

2023 Nov 15;13(11):5590-5609. PMID: 38058825
J Clin Med

DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL. [Abstract]

2023 Jan 12;12(2):608. PMID: 36675536
Toxicol Lett

PGAM5 Regulates DRP1-mediated Mitochondrial Fission/Mitophagy Flux in Lipid Overload-induced Renal Tubular Epithelial Cell Necroptosis. [Abstract]

2023 Jan 1:372:14-24. PMID: 36273635
J Biochem Mol Toxicol

Entinostat Induces Dual Apoptotic and Autophagic Cell Death in Small-Cell Lung Cancer via Epigenetic Modulation of HDAC1-p53-AMPK/mTOR Axis. [Abstract]

2026 Mar;40(3):e70720. PMID: 41817956
J Biochem Mol Toxicol

SP1-Induced GLS2 Promotes Hypoxia/Reoxygenation-Induced AC16 Cell Injury by Regulating Ferroptosis Via an AMPK/mTOR Signaling Pathway. [Abstract]

2026 Mar;40(3):e70768. PMID: 41817959
Int J Biochem Cell Biol

Chromobox protein homolog 7 (CBX7) deficiency inhibits osteoblast ferroptosis by activating the Nrf2 function in type 2 diabetic osteoporosis. [Abstract]

2025 Sep 23:189:106866. PMID: 40998236
J Cancer Res Clin Oncol

Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4. [Abstract]

2024 Sep 23;150(9):429. PMID: 39311951
J Cell Biochem

The HSP90 inhibitor 17-DMAG alleviates primary biliary cholangitis via cholangiocyte necroptosis prevention. [Abstract]

2022 Nov;123(11):1857-1872. PMID: 36037317
Onco Targets Ther

ERK Activation-Mediated Autophagy Induction Resists Licochalcone A-Induced Anticancer Activities in Lung Cancer Cells in vitro. [Abstract]

2021 Jan 8:13:13437-13450. PMID: 33447049
Vet Microbiol

Porcine reproductive and respiratory syndrome virus nsp2 protects viral RNA-dependent RNA polymerase from autophagic degradation. [Abstract]

2026 May:316:110993. PMID: 41861694
Vet Microbiol

SEC10 suppresses KLF15-mediated transcriptional activation of JAK1 and promotes BoHV-1 replication. [Abstract]

2026 May:316:111004. PMID: 41903488
Anal Cell Pathol

PYCR1 Downregulation Induces Autophagy Dependent Apoptosis Through Inhibiting PI3K/AKT/mTOR Axis in Human Hepatocellular Carcinoma Cells. [Abstract]

2026;2026(1):e3662809. PMID: 41810929
Vet Microbiol

Sec6 suppresses BoHV-1-triggered innate immunity through NDP52-mediated autophagic degradation of STING. [Abstract]

2025 Dec 10:312:110836. PMID: 41406560
Vet Microbiol

AS-IV exhibits anti-SADS-CoV effects through the inhibition of the MAPK/JNK signaling pathway mediated by the S1 protein. [Abstract]

2025 Dec 29:313:110858. PMID: 41477941
Vet Microbiol

ENTR1 stabilizes MAVS by inhibiting NIX-mediated mitophagy to restrict BPIV3 and VSV replication. [Abstract]

2025 Dec 31:313:110865. PMID: 41494271
Vet Microbiol

BoHV-1 UL3 inhibits RLR signaling response by degrading MAVS. [Abstract]

2025 Nov 10:312:110791. PMID: 41223816
Radiat Res

Ferroptosis is a Pivotal Player in Radiation-induced Cell Death of Colorectal Cancer Cells. [Abstract]

2025 Nov 14. PMID: 41232566
Vet Microbiol

Porcine reproductive and respiratory syndrome virus nsp2-related proteins induce host translational arrest by specifically impairing the mTOR signaling cascade. [Abstract]

2025 May 13:306:110562. PMID: 40367705
Vet Microbiol

VAPA suppresses BEFV and VSV-induced type I IFNs signaling response by targeting JAK1 for NEDD4-mediated ubiquitin-proteasome degradation. [Abstract]

2025 May:304:110456. PMID: 40080976
Anal Cell Pathol

Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis. [Abstract]

2024 Oct 29:2024:7752299. PMID: 39502521
Vet Microbiol

STAT6 promotes innate immunity against BEFV and VSV by inhibiting STUB1 and NIX-mediated MAVS degradation. [Abstract]

2024 Nov:298:110290. PMID: 39471658
Mol Biol Cell

HSPA8 inhibitors augment cancer chemotherapeutic effectiveness via potentiating necroptosis. [Abstract]

2024 Jul 3:mbcE24040194. PMID: 38959101
Invest New Drugs

IMB5036, a novel pyridazinone compound, inhibits hepatocellular carcinoma growth and metastasis. [Abstract]

2022 Jun;40(3):487-496. PMID: 35020067
Vet Microbiol

Lipid metabolism is a novel and practical source of potential targets for antiviral discovery against porcine parvovirus. [Abstract]

2021 Oct:261:109177. PMID: 34391196
Virus Res

Oncolytic reovirus induces ovarian cancer cell apoptosis in a TLR3-dependent manner. [Abstract]

2021 Aug:301:198440. PMID: 33940002
Exp Eye Res

DCZ3301, an aryl-guanidino agent, inhibits ocular neovascularization via PI3K/AKT and ERK1/2 signaling pathways. [Abstract]

2020 Dec;201:108267. PMID: 32986979
Toxicol In Vitro

YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells. [Abstract]

2020 Dec;69:104971. PMID: 32805372
Vet Microbiol

Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways. [Abstract]

2019 Dec;239:108456. PMID: 31767082
Fitoterapia

4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis. [Abstract]

2025 Apr 23:106567. PMID: 40280251
BMC Gastroenterol

Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer. [Abstract]

2025 Jan 30;25(1):46. PMID: 39885392
Epigenomics

LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac. [Abstract]

2024;16(15-16):1097-1115. PMID: 39268727
Adv Biol (Weinh)

Natural Oncolysis of Enterovirus 71 in Antitumor Therapy of Colorectal Cancer. [Abstract]

2023 Jul;7(7):e2200336. PMID: 37132155
DNA Cell Biol

ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma. [Abstract]

2023 Jun;42(6):336-347. PMID: 37126948
World J Gastrointest Oncol

Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells. [Abstract]

2025 Apr 15;17(4):104922. PMID: 40235896
Chin J Integr Med

Curzerene Induces Apoptosis in Colorectal Cancer Cells Through Inhibition of MEK/ERK Signaling Pathway. [Abstract]

2025 Mar 7. PMID: 40053192
Fundam Clin Pharmacol

The β2-adrenergic receptor agonist formoterol attenuates necrosis and apoptosis in the rat myocardium under experimental stress-induced cardiac injury. [Abstract]

2024 Dec;38(6):1116-1130. PMID: 38956972
Virology

Effects of synonymous codons with optimization / deoptimization in nucleoprotein (NP) gene of influenza A virus on interaction between NP and tripartite motif protein 25 (TRIM25). [Abstract]

2025 Sep:610:110626. PMID: 40669436
Toxicon

Ursolic acid enhances radiosensitivity in esophageal squamous cell carcinoma by modulating p53/SLC7A11/GPX4 pathway-mediated ferroptosis. [Abstract]

2025 Jan 7:108233. PMID: 39788329
PeerJ

Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway. [Abstract]

2022 May 12;10:e13376. PMID: 35582617
Exp Ther Med

Theaflavin-3,3'-digallate attenuates cigarette smoke extract-induced pulmonary emphysema in mice by suppressing necroptosis. [Abstract]

2022 Jan;23(1):11. PMID: 34815763
FEBS Open Bio

PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL-1β-treated rat chondrocytes. [Abstract]

2021 Feb;11(2):435-445. PMID: 33326693
Biochem Biophys Res Commun

Natural exosome-like nanovesicles from Smilax China rhizome induce mitophagy-dependent ferroptosis in hepatocellular carcinoma via GPX4/ACSL4 axis. [Abstract]

2026 Feb 12:800:153270. PMID: 41529459
Biochem Biophys Res Commun

Regorafenib promotes ferroptosis in acute myeloid leukemia by upregulating NOX4. [Abstract]

2025 Dec 15:792:152981. PMID: 41242297
Biochem Biophys Res Commun

Human cytomegalovirus protein UL13 targets to mitochondria to induce cuproptosis. [Abstract]

2025 Sep 1:777:152330. PMID: 40652815
Biochem Biophys Res Commun

Engineered MAP30ER: A plant toxin-derived platform for EGFR-Targeted delivery of protein and chemotherapeutic payloads. [Abstract]

2025 Jun 10:776:152184. PMID: 40517671
Oncol Lett

SNS‑032 combined with decitabine induces caspase‑3/gasdermin E‑dependent pyroptosis in breast cancer cells. [Abstract]

2025 Feb 27;29(4):202. PMID: 40070781
Head Neck

iPLA2β regulates the dual effects of arachidonic acid in thyroid cancer. [Abstract]

2025 Feb;47(2):504-516. PMID: 39290130
Biochem Biophys Res Commun

S-Allyl-L-cysteine (SAC) inhibits copper-induced apoptosis and cuproptosis to alleviate cardiomyocyte injury. [Abstract]

2024 Jul 2:730:150341. PMID: 39018965
Biochem Biophys Res Commun

Guanine nucleotide exchange factor RABGEF1 facilitates TNF-induced necroptosis by targeting cIAP1. [Abstract]

2024 Apr 9:703:149669. PMID: 38377943
Biochem Biophys Res Commun

Sympathetic β2-adrenergic receptor blockade overcomes docetaxel resistance in prostate cancer. [Abstract]

2023 May 21:657:69-79. PMID: 36989842
Biochem Biophys Res Commun

Hydrogen peroxide and iron ions can modulate lipid peroxidation, apoptosis, and the cell cycle, but do not have a significant effect on DNA double-strand break. [Abstract]

2023 Apr 9:651:121-126. PMID: 36822125
Oncol Lett

Norcantharidin induces ferroptosis via the suppression of NRF2/HO-1 signaling in ovarian cancer cells. [Abstract]

2022 Aug 25;24(4):359. PMID: 36168316
Biochem Biophys Res Commun

ACSL4 is overexpressed in psoriasis and enhances inflammatory responses by activating ferroptosis. [Abstract]

2022 Oct 1:623:1-8. PMID: 35868067
Biochem Biophys Res Commun

Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation. [Abstract]

2022 Jan 8:587:99-106. PMID: 34872005
Oncol Lett

Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration. [Abstract]

2021 Jan;21(1):59. PMID: 33281970
Cancer Rep (Hoboken)

Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study. [Abstract]

2025 May;8(5):e70220. PMID: 40347062
Clin Med Insights Oncol

MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells. [Abstract]

2024 Apr 15:18:11795549241244783. PMID: 38628842
Transl Cancer Res

TAF1 inhibitor Bay-299 induces cell death in acute myeloid leukemia. [Abstract]

2021 Dec;10(12):5307-5318. PMID: 35116379
Neurol Res

TPEN attenuates neuronal ferroptosis in ischemic brain injury via GPR39-mediated PI3K/AKT signaling activation. [Abstract]

2025 Oct 21:1-14. PMID: 41117931
Mol Cell Toxicol

2022.
bioRxiv

Small-molecule modulators of HIPK4 activity and proteostasis. [Abstract]

2026 May 14:2026.05.12.724395. PMID: 42182270
bioRxiv

2026 May 5.
bioRxiv

2026 May 8.
Blood Neoplasia

The KDM-family inhibitor JIB-04 sensitizes AML cells to venetoclax by inducing a ferroptosis-like phenotype. [Abstract]

2026 Apr 16;3(3):100236. PMID: 42221838
Dental Research

2026 Mar 24.
bioRxiv

2026 Mar 18.
bioRxiv

2026 Mar 16.
Res Sq

2026 Mar 11.
Res Sq

2026 Jan 12.
bioRxiv

2026 Jan 10.
SSRN

2026 Jan 2.
Res Sq

2026 Jan 13.
Res Sq

2025 Dec 3.
Res Sq 2025 Oct 1
SSRN

2025 Oct 15.
SSRN

2025 Sep 17.
Cornell University

2025.
Res Sq

2025 Jul 16.
SSRN

2025 Jul 16.
Res Sq

2025 Jul 20.
bioRxiv

2025 May 15.
University of Brussels

2025.
SSRN

2025 Jan 24.
SSRN

2025 Feb 21.
bioRxiv

2025 February 27.
J Life Sci

2025.
SSRN

2025 Jan 24.
Res Sq

2025 Feb 16.
University of Zaragoza

2025.
Research Square Preprint

2024 Oct 13.
Res Sq

2024 Sep 16.
University of Liege

2024.
bioRxiv

Effects of intergenerational transmission of small intestinal bacteria cultured from stunted Bangladeshi children with enteropathy. [Abstract]

2024 Nov 3:2024.11.01.621574. PMID: 39554152
Res Sq

2024 Oct 27.
Patent

US20240279284A1.
bioRxiv

2024 September 10.
Res Sq

2024 Jul 15.
SSRN

2024 May 22.
J Tradit Chinese Medical Sci

2024 Jun 5.
Research Square Preprint

2024 Mar 28.
Research Square Preprint

2024 Apr 10.
Research Square Preprint

2024 Apr 2.
bioRxiv

2024 Jan 22.
SSRN

2023 Dec 11.
SSRN

2023 Nov 8.
Research Square Preprint

2023 Oct 13.
Research Square Preprint

2023 Sep 15.
SSRN

2023 May 22.
bioRxiv

2023 Apr 25.
Research Square Print

2023 Feb 8.
Oxid Med Cell Longev

Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer. [Abstract]

2023 Jan 31:2023:1367938. PMID: 36760347
Research Square Print

November 8th, 2022
Research Square Print

October 14th, 2022.
Oxid Med Cell Longev

Energy-Stress-Mediated AMPK Activation Promotes GPX4-Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer. [Abstract]

2022 Oct 4:2022:2353115. PMID: 36246395
SSRN

26 Oct 2022.
Pharmacological Research-Modern Chinese Medicine

29 August 2022, 100157.
Oxid Med Cell Longev

Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway. [Abstract]

2022 Aug 4:2022:9325973. PMID: 35965682
Oxid Med Cell Longev

Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells. [Abstract]

2022 Jun 8:2022:8585598. PMID: 35720178
Oxid Med Cell Longev

AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway. [Abstract]

2022 Jun 13:2022:8091464. PMID: 35733794
Research Square Print

2022 May.
Research Square Preprint

2022 Jan.
Evid Based Complement Alternat Med

Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells. [Abstract]

2022 Jan 17:2022:7548191. PMID: 35082905
Universität Würzburg

2021 Oct.
Oxid Med Cell Longev

Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction. [Abstract]

2021 Oct 19:2021:8963987. PMID: 34712388
Oxid Med Cell Longev

Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. [Abstract]

2021 Aug 31;2021:5608133. PMID: 34512867
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 May.
Research Square Preprint

2021 May.
Research Square Preprint

2021 Jul.
Research Square Preprint

2020 Oct.
University of Michigan

2020 Oct.
Research Square Preprint

2020 Sep.
Universitat Politècnica de València

2020 Sep 7.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (220.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2053 mL

11.0263 mL

22.0527 mL

5 mM

0.4411 mL

2.2053 mL

4.4105 mL

10 mM

0.2205 mL

1.1026 mL

2.2053 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.08 mg/mL (4.59 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Slee EA, et al. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J. 1996 Apr 1;315 ( Pt 1)(Pt 1):21-4. [Content Brief]

[2]. Martinet W, et al. Z-VAD-FMK-induced non-apoptotic cell death of macrophages: possibilities and limitations for atherosclerotic plaque stabilization. Autophagy. 2006 Oct-Dec;2(4):312-4. [Content Brief]

[3]. Pero ME, Zullo G, Esposito L, Iannuzzi A, Lombardi P, De Canditiis C, Neglia G, Gasparrini B. Inhibition of apoptosis by caspase inhibitor Z-VAD-FMK improves cryotolerance of in vitro derived bovine embryos. Theriogenology. 2018 Mar 1;108:127-135. [Content Brief]

[4]. Lawrence CP, Chow SC. Suppression of human T cell proliferation by the caspase inhibitors, Z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):103-12. [Content Brief]

[5]. Rajah T, Chow SC. The inhibition of human T cell proliferation by the caspase inhibitor Z-VAD-FMK is mediated through oxidative stress. Toxicol Appl Pharmacol. 2014 Jul 15;278(2):100-6. [Content Brief]

[6]. He M, et al. Effects of Z-VaD-Ala-Asp-Fluoromethyl Ketone (Z-VAD-FMK) and Acetyl-Asp-Glu-Val-Asp-Aldehyde(Ac-DEVD-CHO) on Inflammation and Mucus Secretion in Mice Exposed to Cigarette Smoke. Int J Chron Obstruct Pulmon Dis. 2023 Feb 5;18:69-78. [Content Brief]

[7]. Liu M, et al. Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis. Pancreatology. 2016 Sep-Oct;16(5):733-8. [Content Brief]

[8]. Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42. [Content Brief]

[9]. Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2053 mL	11.0263 mL	22.0527 mL	55.1317 mL
	5 mM	0.4411 mL	2.2053 mL	4.4105 mL	11.0263 mL
	10 mM	0.2205 mL	1.1026 mL	2.2053 mL	5.5132 mL
	15 mM	0.1470 mL	0.7351 mL	1.4702 mL	3.6754 mL
	20 mM	0.1103 mL	0.5513 mL	1.1026 mL	2.7566 mL
	25 mM	0.0882 mL	0.4411 mL	0.8821 mL	2.2053 mL
	30 mM	0.0735 mL	0.3675 mL	0.7351 mL	1.8377 mL
	40 mM	0.0551 mL	0.2757 mL	0.5513 mL	1.3783 mL
	50 mM	0.0441 mL	0.2205 mL	0.4411 mL	1.1026 mL
	60 mM	0.0368 mL	0.1838 mL	0.3675 mL	0.9189 mL
	80 mM	0.0276 mL	0.1378 mL	0.2757 mL	0.6891 mL
	100 mM	0.0221 mL	0.1103 mL	0.2205 mL	0.5513 mL

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Z-VAD-FMK

Cell Death Inhibitor Library Mini

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Z-VAD-FMK

All Caspase Isoforms

All RIP kinase Isoforms

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Publications (755)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Z-VAD-FMK

Cell Death Inhibitor Library Mini

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Z-VAD-FMK

All Caspase Isoforms

All RIP kinase Isoforms

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Publications (755)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Z-VAD-FMK Related Classifications

Cat. No.: HY-16658B