Antitumor agent-170
Antitumor agent-170 (Compound C6) exhibits inhibitory activities against PD-1/PD-L1 interaction and PARP7, with IC50 of 0.342 μM and 7.05 nM. Antitumor agent-170 exhibits a high affinity to human PD-L1, with a Ki of 9.31 nM. Antitumor agent-170 restores the T cell function and increases IFN-γ secretion. Antitumor agent-170 exhibits antitumor efficacy against melanoma in mouse models and good pharmacokinetic characteristics.
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- Formule: C59H69ClF3N11O9
- Masse moléculaire:1168.70
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PARP7 7.05 nM (IC50) |
Chemical Information
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Masse moléculaire 1168.70
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Formule C59H69ClF3N11O9
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SMILES
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=C(C=C(C(OCC4=CN=CC=C4)=C3)CN5CCCC[C@H]5C(NCCOCCOCCNC(C6=CN=C(N=C6)N7CCN(CC7)C(CCOC[C@H](C)NC8=C(C(NN=C8)=O)C(F)(F)F)=O)=O)=O)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-170 Related Classifications
HY-162644 Related Classifications
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