Cat. No.: HY-120692

Cyclanoline chloride

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Cyclanoline chloride is an alkaloid. Cyclanoline chloride can be isolated from Fangji. Cyclanoline (chloride) inhibits the phosphorylation of JAK2 and STAT3, and induces Apoptosis. Cyclanoline chloride suppresses tumor growth in subcutaneous bladder cancer xenograft models of nude mice. Cyclanoline chloride reverses cisplatin resistance in bladder cancer cells and enhances the efficacy of Cisplatin (HY-17394). Cyclanoline chloride can be used for research related to bladder cancer.

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Pureté: 96.27%
CAS No.: 17472-50-3
Formule: C₂₀H₂₄ClNO₄
Masse moléculaire:377.86

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cyclanoline chloride Chemical Structure

CAS No.: 17472-50-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

JAK2

STAT3

Voir tous les produits spécifiques à Isoform JAK :

Voir tous les produits spécifiques à Isoform STAT :

In Vitro

Cyclanoline (50 μM; 24 h) chloride inhibits the JAK2/STAT3 pathway in cisplatin-resistant human bladder cancer T24/DR cells, reducing cell migration and invasion, promoting apoptosis, inducing G₀/G₁ phase cell cycle arrest, and reversing cisplatin resistance, with enhanced effects when combined with cisplatin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyclanoline (chloride) (40 mg/kg; i.p.; every 2 days; 13 administrations) chloride significantly inhibits growth of cisplatin-resistant bladder cancer xenografts in nude mice and downregulates p-STAT3 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c nude (male, 4-5 weeks old, subcutaneous xenograft model)^[1]
Dosage:

40 mg/kg
Administration:

i.p.; every 2 days; 13 administrations
Result:

Reduced tumor volumes and masses significantly compared to control group, with tumor inhibitory effect superior to cisplatin alone.
Downregulated p-STAT3 protein expression in tumor tissue significantly compared to control group.

Chemical Information

CAS No. 17472-50-3
Appearance Solid
Masse moléculaire 377.86
Formule C₂₀H₂₄ClNO₄
Color Off-white to light brown
SMILES

C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC=C(OC)C(O)=C4C2.[Cl-]
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (264.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6465 mL

13.2324 mL

26.4648 mL

5 mM

0.5293 mL

2.6465 mL

5.2930 mL

10 mM

0.2646 mL

1.3232 mL

2.6465 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li L, et al. Cyclanoline Reverses Cisplatin Resistance in Bladder Cancer Cells by Inhibiting the JAK2/STAT3 Pathway. Anticancer Agents Med Chem. 2024;24(18):1360-1370. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6465 mL	13.2324 mL	26.4648 mL	66.1621 mL
	5 mM	0.5293 mL	2.6465 mL	5.2930 mL	13.2324 mL
	10 mM	0.2646 mL	1.3232 mL	2.6465 mL	6.6162 mL
	15 mM	0.1764 mL	0.8822 mL	1.7643 mL	4.4108 mL
	20 mM	0.1323 mL	0.6616 mL	1.3232 mL	3.3081 mL
	25 mM	0.1059 mL	0.5293 mL	1.0586 mL	2.6465 mL
	30 mM	0.0882 mL	0.4411 mL	0.8822 mL	2.2054 mL
	40 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6541 mL
	50 mM	0.0529 mL	0.2646 mL	0.5293 mL	1.3232 mL
	60 mM	0.0441 mL	0.2205 mL	0.4411 mL	1.1027 mL
	80 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8270 mL
	100 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6616 mL

Keywords

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Cyclanoline chloride

Apoptosis Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

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Anti-Aging Compound Library

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Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Autoimmune Disease Compound Library

Cell Death Library

Anti-Drug-Resistant Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform JAK

Voir tous les produits spécifiques à Isoform STAT

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Cyclanoline chloride Related Classifications

HY-120692 Related Classifications