Cyy-272
Cyy-272 is an orally active JNK inhibitor with IC50 values of 1.25 μM for JNK1, 1.07 μM for JNK2, and 1.24 μM for JNK3. Cyy-272 exerts anti-inflammatory effects by inhibiting JNK phosphorylation, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS, HY-D1056). Additionally, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissue induced by high lipid concentrations, further mitigating cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 can be used in the study of obese cardiomyopathy.
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- CAS No.: 2644673-01-6
- Formule: C23H23F2N7
- Masse moléculaire:435.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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JNK1 1.25 μM (IC50) |
JNK2 1.07 μM (IC50) |
JNK3 1.24 μM (IC50) |
Chemical Information
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CAS No. 2644673-01-6
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Masse moléculaire 435.47
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Formule C23H23F2N7
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SMILES
CC1=C(N=C(N=C1)NC2=CC=C(C=C2)N3CCC(F)(CC3)F)NC4=CC=C5C=NNC5=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyy-272 Related Classifications
HY-169052 Related Classifications
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