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Cat. No.: HY-15882

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GNE-783

GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines.

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CAS No.: 1200127-66-7
Formule: C₂₂H₂₀N₆
Masse moléculaire:368.43

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GNE-783 Chemical Structure

CAS No.: 1200127-66-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- Cellular Effect
Chemical Information
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	EC₅₀	97.7 nM Compound: 1, GNE-783	Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assay Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assay	[PMID: 25988399]
HT-29	GI₅₀	>25 μM Compound: 16, GNE-783	Antiproliferative activity against human HT-29 cells assessed as growth inhibition Antiproliferative activity against human HT-29 cells assessed as growth inhibition	[PMID: 25453805]
HT-29	IC₅₀	0.098 μM Compound: 16, GNE-783	Inhibition of ChK1 in human HT-29 cells assessed as phospho-histone H3 by Isobologram assay Inhibition of ChK1 in human HT-29 cells assessed as phospho-histone H3 by Isobologram assay	[PMID: 25453805]

Chemical Information

CAS No. 1200127-66-7
Masse moléculaire 368.43
Formule C₂₂H₂₀N₆
SMILES

N#CC1=NC=C2C(C3=CC(C4=CC=C(N5CCN(C)CC5)C=C4)=CN=C3N2)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor

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100 mg

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Activité biologique
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GNE-783

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

GNE-783 Related Classifications

HY-15882 Related Classifications