Ophiobolin C
Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells.
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- CAS No.: 19022-51-6
- Formule: C25H38O3
- Masse moléculaire:386.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CCR5 |
HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
40 μM
Compound: 2
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Displacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cells
Displacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cells
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[PMID: 15217290] |
Chemical Information
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CAS No. 19022-51-6
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Masse moléculaire 386.57
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Formule C25H38O3
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SMILES
O=C/C1=C/C[C@]([C@@H]([C@@H](C)CC/C=C(C)\C)CC2)([H])[C@@]2(C)C[C@@]([C@](C)(O)C3)([H])[C@]1([H])C3=O
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Synonyms
Zizanin A
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Jayasuriya H, et al. Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod. 2004 Jun;67(6):1036-8. [Content Brief]
[2]. Bladt TT, et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules. 2013 Nov 26;18(12):14629-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ophiobolin C Related Classifications
HY-123902 Related Classifications
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