Tyromycin A
Tyromycin A is an inhibitor targeting Leu-AP, Cys-AP and CP-A, with an IC50 value of 25-41 μg/mL against porcine Leu-AP and an IC50 value of 60 μg/mL against bovine CP-A. Tyromycin A inhibits the hydrolytic activity of target peptidases and exhibits selective activity against Gram-positive bacteria. Tyromycin A moderately inhibits the infectivity of HCV in human hepatocytes, with an IC50 of 6.6 μM, and its inhibitory activity depends on the two maleic anhydride domains. Tyromycin A can be used in studies related to Gram-positive bacterial infections and hepatitis C virus infections.
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- CAS No.: 141364-77-4
- Formule: C26H38O6
- Masse moléculaire:446.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HCV 6.6 μM (IC50) |
Leu-AP 25-41 μg/mL (IC50) |
CP-A 60 μg/mL (IC50) |
Tyromycin A (30 min) inhibits leucine aminopeptidase bound to the surface of HeLa S3 cells with a Ki value of 4×10-5 M; it also inhibits cysteine aminopeptidase with a Ki value of 1.3×10-5 M[1].
Tyromycin A inhibits porcine kidney cytosolic leucine aminopeptidase (IC50 25-31 μg/mL), porcine kidney microsomal leucine aminopeptidase (IC50 27-41 μg/mL), and bovine pancreatic carboxypeptidase A (IC50 60 μg/mL) in cell-free assays[1].
Tyromycin A (30 min) weakly inhibits leucine aminopeptidase activity in HeLa (KB3.1) cells, with an IC50 greater than 150 μg/mL at both 50 μM and 100 μM L-Leu-AMC substrate concentrations[2].
Tyromycin A (30 min) weakly inhibits leucine aminopeptidase activity in HeLa (KB3.1) cells, with an IC50 >150 μg/mL at both 50 μM and 100 μM L-Leu-AMC substrate concentrations[2].
Tyromycin A selectively inhibits the growth of Gram-positive bacteria, with the strongest inhibitory activity against *Bacillus subtilis* DSM10 (MIC = 9.375 μg/mL), and shows no activity against the tested Gram-negative bacteria or fungi[2].
Tyromycin A exhibits selective activity against Gram-positive bacteria, with the strongest potency against *Bacillus subtilis* DSM10 (MIC = 9.375 μg/mL), and shows no activity against Gram-negative bacteria or fungi[2].
Tyromycin A (40 μM; 3 days) moderately inhibits HCV infectivity in Huh-7.5 human hepatocytes, with an IC50 of 6.6 μM[2].
Tyromycin A (100 μg/mL) shows no significant nematicidal activity against *Caenorhabditis elegans*[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 141364-77-4
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Masse moléculaire 446.58
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Formule C26H38O6
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SMILES
O=C1OC(C(CCCCCCCCCCCCCCCCC(C(O2)=O)=C(C)C2=O)=C1C)=O
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Structure Classification
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Initial Source
from the Kenyan WoodInhabiting Basidiomycete, Skeletocutis sp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Weber W, et al. Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus. Planta Med. 1992 Feb;58(1):56-9. [Content Brief]
[2]. Chepkirui C, et al. Skeletocutins A-L: Antibacterial Agents from the Kenyan Wood-Inhabiting Basidiomycete, Skeletocutis sp. J Agric Food Chem. 2019 Aug 7;67(31):8468-8475. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyromycin A Related Classifications
HY-N19639 Related Classifications
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