141364-77-4
Chemical Structure
Tyromycin A
- CAS No.: 141364-77-4
- Formula:C26H38O6
- Molecular Weight:446.58
InChIKey: ZOXQKIRYCLFUCD-UHFFFAOYSA-N
SMILES: O=C1OC(C(CCCCCCCCCCCCCCCCC(C(O2)=O)=C(C)C2=O)=C1C)=O
Biological Activity: Tyromycin A is an inhibitor targeting Leu-AP, Cys-AP and CP-A, with an IC50 value of 25-41 μg/mL against porcine Leu-AP and an IC50 value of 60 μg/mL against bovine CP-A. Tyromycin A inhibits the hydrolytic activity of target peptidases and exhibits selective activity against Gram-positive bacteria. Tyromycin A moderately inhibits the infectivity of HCV in human hepatocytes, with an IC50 of 6.6 μM, and its inhibitory activity depends on the two maleic anhydride domains. Tyromycin A can be used in studies related to Gram-positive bacterial infections and hepatitis C virus infections[1][2].
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Tyromycin A | Tyromycin A is an inhibitor targeting Leu-AP, Cys-AP and CP-A, with an IC50 value of 25-41 μg/mL against porcine Leu-AP and an IC50 value of 60 μg/mL against bovine CP-A. Tyromycin A inhibits the hydrolytic activity of target peptidases and exhibits selective activity against Gram-positive bacteria. Tyromycin A moderately inhibits the infectivity of HCV in human hepatocytes, with an IC50 of 6.6 μM, and its inhibitory activity depends on the two maleic anhydride domains. Tyromycin A can be used in studies related to Gram-positive bacterial infections and hepatitis C virus infections. | |||||||||||||||||||||
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- [1]. Weber W, et al. Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus. Planta Med. 1992 Feb;58(1):56-9. [Content Brief]
- [2]. Chepkirui C, et al. Skeletocutins A-L: Antibacterial Agents from the Kenyan Wood-Inhabiting Basidiomycete, Skeletocutis sp. J Agric Food Chem. 2019 Aug 7;67(31):8468-8475. [Content Brief]
Keywords
