1000026-77-6
1000026-77-6
Chemical Structure
Sinomenine N-oxide
Synonym(s): (+)-Sinomenine N-oxide
- CAS No.: 1000026-77-6
- Formula:C19H23NO5
- Molecular Weight:345.39
InChIKey: IQCNMIIBBLJCAC-RTFQWSFESA-N
SMILES: OC1=C2[C@]34[C@@](C=C(C(C4)=O)OC)([H])[C@@H]([N@@+]([O-])(CC3)C)CC2=CC=C1OC
Biological Activity: Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM[1][2][3].
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Sinomenine N-oxide | ≥99.0% | Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM. | ||||||||||||||||||||
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References
- [1]. Liu WJ, et al. Network pharmacology approach to elucidate possible action mechanisms of Sinomenii Caulis for treating osteoporosis. J Ethnopharmacol. 2020 Jul 15;257:112871. [Content Brief]
- [2]. Zeng HL, et al. New N-oxide alkaloids from the stems of Sinomenium acutum. Fitoterapia. 2023 Mar;165:105404. [Content Brief]
- [3]. Li Q, et al. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sci. 2020 Nov 15;261:118433. [Content Brief]
Keywords
