1004319-60-1
Chemical Structure
Antiviral agent 64
- CAS No.: 1004319-60-1
- Formula:C21H26O4
- Molecular Weight:342.43
InChIKey: XYIISUAVSYEQLI-LJQANCHMSA-N
SMILES: O=C(CCC1=CC=CC=C1)C[C@H](OC)CCC2=CC(OC)=C(C=C2)O
Biological Activity: Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC50 of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC50 of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively[1][2][3].
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Antiviral agent 64 | Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC50 of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC50 of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively. | |||||||||||||||||||||
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- [1]. Sun, Yi; et al., New Cytotoxic Diarylheptanoids from the Rhizomes ofAlpinia officinarum. Planta Medica, 74(4), 427–431. [Content Brief]
- [2]. Sawamura R, et al., Antiviral activities of diarylheptanoids against influenza virus in vitro. J Nat Med. 2010 Jan;64(1):117-20. [Content Brief]
- [3]. Konno K, et al. Antiviral activities of diarylheptanoids isolated from Alpinia officinarum against respiratory syncytial virus, poliovirus, measles virus, and herpes simplex virus type 1 in vitro[J]. Natural product communications, 2011, 6(12): 1934578X1100601222.
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