1020719-72-5
1020719-72-5
Chemical Structure
Penciclovir-d4
Synonym(s): BRL 39123-d4;VSA 671-d4
- CAS No.: 1020719-72-5
- Formula:C10H11D4N5O3
- Molecular Weight:257.28
IUPAC Name: 2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl-1,1,2,2-d4)-3,9-dihydro-6H-purin-6-one
InChIKey: JNTOCHDNEULJHD-LNLMKGTHSA-N
SMILES: OCC(CO)C([2H])([2H])C([2H])([2H])N1C2=C(C(N=C(N2)N)=O)N=C1
Biological Activity: Penciclovir-d4 is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Penciclovir-d4 | Penciclovir-d4 is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively. | |||||||||||||||||||||
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Penciclovir (Standard) | 99.44% | Penciclovir (Standard) is the analytical standard of Penciclovir. This product is intended for research and analytical applications. Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse. | ||||||||||||||||||||
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Penciclovir | 99.81% | Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 μg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse. | ||||||||||||||||||||
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Lobucavir | Lobucavir (BMS-180194; SQ 34514)，a nucleoside analogue，is an antiviral agent. Lobucavir shows a broad spectrum of activity against HBV，HIV/AIDS，and α，β，and γ herpes viruses including CMV，herpes-simplex，varicella-zoster，and Epstein-Barr virus. | |||||||||||||||||||||
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(±)-Lobucavir | (±)-Lobucavir ((±)-BMS-180194) is a nucleoside analog with carcinogenic activity. In mice, chronic administration of (±)-Lobucavir resulted in tumor formation with a tumor spectrum similar to that observed after chronic administration of zidovudine or ganciclovir. | |||||||||||||||||||||
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Tiviciclovir | Tiviciclovir (AM188) is an antiviral guanosine analog and a hepatitis B virus inhibitor. | |||||||||||||||||||||
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Penciclovir sodium | Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse. | |||||||||||||||||||||
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Omaciclovir | 99.47% | Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity. | ||||||||||||||||||||
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Ganciclovir | 99.89% | Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain. | ||||||||||||||||||||
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9-Carboxymethoxymethylguanine | 9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. | |||||||||||||||||||||
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Acyclovir | 99.18% | Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia. | ||||||||||||||||||||
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UA2239 | UA2239 is an antimalarial agent and acyclic nucleoside phosphonate. UA2239 disrupts the essential cGMP-dependent egress pathway by decreasing cGMP levels. UA2239 targets guanylyl cyclase α. UA2239 demonstrates rapid and irreversible inhibitory effects on Plasmodium parasites. | |||||||||||||||||||||
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6-Deoxypenciclovir | 99.83% | 6-Deoxypenciclovir is an inactive metabolite of the antiviral prodrug Famciclovir. 6-Deoxypenciclovir is a good substrate for rabbit hepatic aldehyde oxidase and can be used to synthesize the prodrug form of penciclovir. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Piret J, et al. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. Antimicrob Agents Chemother. 2011 Feb;55(2):459-72. [Content Brief]
