1025007-04-8
1025007-04-8
Chemical Structure
TC-6683
Synonym(s): AZD1446
- CAS No.: 1025007-04-8
- Formula:C11H13ClN2O2
- Molecular Weight:240.69
IUPAC Name: (5-chlorofuran-2-yl)(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone
InChIKey: GTUIQNHJSXQMKW-UHFFFAOYSA-N
SMILES: O=C(N1CC2CNCC2C1)C3=CC=C(Cl)O3
Biological Activity: TC-6683 (AZD1446) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist. TC-6683 does not show significant therapeutic effects in the animal model of DYT1 dystonia.TC-6683 can be used for the research of neurological disease, such as cognitive disorder[1][2].
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TC-6683 | TC-6683 (AZD1446) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist. TC-6683 does not show significant therapeutic effects in the animal model of DYT1 dystonia.TC-6683 can be used for the research of neurological disease, such as cognitive disorder. | |||||||||||||||||||||
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References
- [1]. Mazurov AA, et al. Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. J Med Chem. 2012 Nov 8;55(21):9181-94. [Content Brief]
- [2]. Zimmerman CN, et al. Evaluation of AZD1446 as a Therapeutic in DYT1 Dystonia. Front Syst Neurosci. 2017 Jun 13;11:43. [Content Brief]
Keywords
